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DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.
2-Methylmethcathinone (also known as 2-MMC, Ortho or Orthomephedrone) is a novel lesser-known stimulant-entactogen substance of the cathinone class that induces feelings of euphoria, and stimulation. It is related to other substituted cathinones like for example 3-MMC or 4-MMC (Mephedrone). The mechanism of action is not fully studied, but dopamine, serotonin and norepinephrine releasing activity is known to be involved.
2-MMC is shown to be more dopaminergic and less serotonergic compared to MDMA. This profile makes it more stimulating and less empathogenic, similar to that of Amphetamine.
It was first identified in Sweden in May 2014.[1]. Until recently, it had beeen an obscure substance, unclassified in many countries. Cases of its use were sporadic. However, since the Dutch ban on 3-MMC, the sale and use of 2-MMC became prevalent in the Netherlands.[citation needed]
Chemistry
2-Methylmethcathinone's chemical name is 2-(methylamino)-1-phenylpropan-1-one and is a cathinone derivative, which is a synthetic form of phenylethylamines. 2-MMC has a cathinone which is substituted with a methyl group at the 2 position which makes it a structural isomer of Metaphedrone.
Disclaimer: The effects listed below cite the Subjective Effect Index (SEI), an open research literature based on anecdotal user reports and the personal analyses of PsychonautWikicontributors. As a result, they should be viewed with a healthy degree of skepticism.
It is also worth noting that these effects will not necessarily occur in a predictable or reliable manner, although higher doses are more liable to induce the full spectrum of effects. Likewise, adverse effects become increasingly likely with higher doses and may include addiction, severe injury, or death ☠.
Physical effects
Stimulation - Orthomephedrone is reported to be extremely energetic and stimulating in a fashion that is similar to that of MDMA or at higher dosages Amphetamine but stronger than that of modafinil or caffeine. It encourages physical activities like running, walking, or dancing which would otherwise be boring. The particular style of stimulation which orthomephedrone presents can be described as forced. This means that at higher dosages, it becomes difficult or impossible to keep still as jaw clenching, involuntarily bodily shakes and vibrations become present, resulting in extreme shaking of the entire body, unsteadiness of the hands, and a general lack of motor control.
Difficulty urinating - Higher doses of orthomephedrone can result in a burning-like sensation when urinating, or an overall difficulty peeing. An effect that is completely temporary and thought to be harmless.
Mouth numbing - Particularly when insufflated, leaves a numbing sensation in one's throat.
Vibrating vision - At overly high dosages or binging a person's eyeballs may begin to spontaneously wiggle back and forth in a rapid motion, causing the vision to become blurry and temporarily out of focus. This is a condition known as nystagmus.
Seizure - This is a very rare effect but can likely happen in those predisposed to them, especially while in physically taxing conditions such as being dehydrated, undernourished, overheated, fatigued or when combining with other substances that lower the seizure threshold.
Memory suppression - 2-MMC's positional isomer 4-MMC has been shown to negatively impact short-term memory[2] and 2-MMC itself anecdotally is said to have immediate disruptive effects on memory.
Delirium & Confusion - This effect typically only occurs with overly high doses, and is associated with temperature dysregulation, sleep deprivation and overheating, particularly when 2-MMC is taken in crowded, physically strenuous environments that leaves the user unable to cool off, rest, or rehydrate adequately.
The effects which occur during the offset of a stimulant experience generally feel negative and uncomfortable in comparison to the effects which occurred during its peak. This is often referred to as a "comedown" and occurs because of neurotransmitter depletion. Its effects commonly include:
The "comedown" on 2-MMC is reported to be a smooth and clear gradual return to sobriety rather than a crash, which, by users is reported to be a lot less uncomfortable than traditional stimulant crash.
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Experience reports
There are currently 1 experience reports describing the effects of this substance in our experience index. You can also submit your own experience report using the same link.
This toxicity and harm potential section is a stub.
As a result, it may contain incomplete or even dangerously wrong information! You can help by expanding upon or correcting it. Note: Always conduct independent research and use harm reduction practices if using this substance.
Like other cathinones, 2-MMC remains a highly addictive substance
Dangerous interactions
Warning:Many psychoactive substances that are reasonably safe to use on their own can suddenly become dangerous and even life-threatening when combined with certain other substances. The following list provides some known dangerous interactions (although it is not guaranteed to include all of them).
Always conduct independent research (e.g. Google, DuckDuckGo, PubMed) to ensure that a combination of two or more substances is safe to consume. Some of the listed interactions have been sourced from TripSit.
]] & ]] - 25x compounds are highly stimulating and physically straining. Combinations with 2-MMC should be strictly avoided due to the risk of excessive stimulation and heart strain. This can result in increased blood pressure, vasoconstriction, panic attacks, thought loops, seizures, and heart failure in extreme cases.
]] - Combining alcohol with stimulants can be dangerous due to the risk of accidental over-intoxication. Stimulants mask alcohol's depressant effects, which is what most people use to assess their degree of intoxication. Once the stimulant wears off, the depressant effects will be left unopposed, which can result in blackouts and severe respiratory depression. If mixing, the user should strictly limit themselves to only drinking a certain amount of alcohol per hour.
]] - Combinations with DXM should be avoided due to its inhibiting effects on serotonin and norepinephrine reuptake. There is an increased risk of panic attacks and hypertensive crisis, or serotonin syndrome with serotonin releasers (MDMA, methylone, mephedrone, etc.). Monitor blood pressure carefully and avoid strenuous physical activity.
]] - Any neurotoxic effects of MDMA are likely to be increased when other stimulants are present. There is also a risk of excessive blood pressure and heart strain (cardiotoxicity).
]] - Some reports suggest combinations with MXE may dangerously increase blood pressure and increase the risk of mania and psychosis.
]] - Both classes carry a risk of delusions, mania and psychosis, and these risk may be multiplied when combined.
]] - Tramadol is known to lower the seizure threshold[3] and combinations with stimulants may further increase this risk.
Cocaine - This combination may increase strain on the heart.
Legal status
Germany: 2-MMC is controlled under the NpSG (New Psychoactive Substances Act)[4] as of November 26, 2016.[5] Production and import with the aim to place it on the market, administration to another person and trading is punishable. Possession is illegal but not penalized.[6]
Poland: Illegal in Poland, the substance is not included in the list of groups of psychotropic substances, however, it falls under the group of psychotropic substances of group I-P as isomer of 3-MMC (metaphedrone) and 4-MMC (mephedrone).
↑Talaie, H.; Panahandeh, R.; Fayaznouri, M. R.; Asadi, Z.; Abdollahi, M. (2009). "Dose-independent occurrence of seizure with tramadol". Journal of Medical Toxicology. 5 (2): 63–67. doi:10.1007/BF03161089. eISSN1937-6995. ISSN1556-9039. OCLC163567183.
↑"Anlage NpSG" (in Deutsch). Bundesministerium der Justiz und für Verbraucherschutz. Retrieved December 19, 2019.
