This is an unofficial archive of PsychonautWiki as of 2025-08-08T03:33:20Z. Content on this page may be outdated, incomplete, or inaccurate. Please refer to the original page for the most up-to-date information.
WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section.
DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.
The effects of methallylescaline were first described by Alexander Shulgin in his book PiHKAL: A Chemical Love Story. He lists the dosage range as 40mg to 60mg orally and describes the duration of action to be 8 - 12 hours.[1] Anecdotal reports portray that methallylescaline bears the most similarity to mescaline, although higher dosages can produce a strong body load.
Very little data exists about the pharmacological properties, metabolism, and toxicity of methallylescaline, and it has little history of human usage. It is highly advised to use harm reduction practices if using this substance.
Methallylescaline, or 4-methallyloxy-3,5-dimethoxyphenethylamine, is a substituted phenethylamine featuring a phenyl ring bound to an amino (NH2) group through an ethyl chain. Methallylescaline contains two methoxy functional groups (CH3O-) which are attached to carbons R3 and R5 of the phenyl ring.
Methallylescaline is substituted at R4 with a methallyloxy chain. This three carbon chain consists of a R2 methyl substituted allyl group with a double bond on the terminal carbon. This chain is connected to the phenyl ring at R4 through an ether (oxygen) bridge.
Methallylescaline likely acts as a 5-HT2Apartial agonist. The psychedelic effects are believed to come from methallylescaline's efficacy at the 5-HT2A receptors. However, the role of these interactions and how they result in the psychedelic experience continues to remain elusive.
Disclaimer: The effects listed below cite the Subjective Effect Index (SEI), an open research literature based on anecdotal user reports and the personal analyses of PsychonautWikicontributors. As a result, they should be viewed with a healthy degree of skepticism.
It is also worth noting that these effects will not necessarily occur in a predictable or reliable manner, although higher doses are more liable to induce the full spectrum of effects. Likewise, adverse effects become increasingly likely with higher doses and may include addiction, severe injury, or death ☠.
Physical effects
Stimulation - In terms of its effects on the physical energy levels of the user, methallylescaline is usually considered to be very energetic and stimulating. For example, when taken in any environment it will usually encourage physical activities such as running, walking, climbing or dancing. In comparison, other more commonly used psychedelics such as psilocin are generally sedating and relaxed.
Spontaneous bodily sensations - The "body high" of methallylescaline can be described as proportionally intense in comparison to its accompanying visual and cognitive effects. It is manifested in a number of forms including an intense soft, warm glow that grows over the body and is capable of becoming extremely physically euphoric. This is most similar to MDMA and MDA and is consistently manifested throughout the experience. This is contrasted by an intensely pleasurable yet sharp, cold electric tingling sensation which moves up and down the body. This is most similar to mescaline and is also consistently manifested throughout the trip. The final physical effect noticed throughout the experience is an intense energetic pins and needles sensation that manifests itself in the form of a continuously shifting and tingling sensation that travels up and down the body in spontaneous waves. This is most similar to 2C-I and is not entirely consistent throughout the trip.
Physical euphoria - Relative to other psychedelics, methallylescaline has been noted for the bodily or physically euphoric aspect that is vaguely reminiscent of other phenethylamines like MDA.
Nausea - Nausea is commonly reported when consumed in moderate to high doses and either passes instantly once the user has vomited or gradually fades by itself as the peak sets in.
Muscle cramp - This is uncommon, but is more likely to occur if one is malnourished, dehydrated, or engaged in strenuous activity.
Tactile enhancement - Feelings of enhanced tactile sensations are consistently present at moderate levels throughout most methallylescaline experiences. If Level 8A geometry is reached, an intense sensation of suddenly becoming aware of and being able to feel every single nerve ending across a person's entire body all at once is consistently present.
Difficulty urinating - A notable side effect of methallylescaline is the occurrence of urinary retention, where users may experience difficulty urinating despite a frequent or urgent urge to do so. This effect can result in discomfort and frustration, as the physical sensation of needing to urinate persists without successful relief. It tends to be more pronounced at higher doses and may continue for several hours after the peak effects. While not universally experienced, it can be a significant concern for some users, especially if they are prone to bladder discomfort or if the urge to urinate becomes overwhelming without being able to find relief. Urinary retention can be managed with alpha blockers such as tamsulosin, which relax the muscles and promote urination.
The visual geometry encountered on methallylescaline can be described as similar in appearance to that of ayahuasca or psilocin in the sense that its geometry is structured in its organization as well as natural and organic in style. However, in terms of its bright color palette and sharp edges, it is also similar to that of LSD, 2C-B and 2C-I.
Level 8B - While the geometry produced by mescaline has yet to be fully characterized, the geometry gives off certain attributes which are significantly more likely to result in states of level 8A visual geometry over level 8B at higher doses.
There are currently 0 experience reports describing the effects of this substance in our experience index. You can also submit your own experience report using the same link.
The toxicity and long-term health effects of recreational methallylescaline use do not seem to have been studied in any scientific context and the exact toxic dose is unknown. This is because methallylescaline is a research chemical with very little history of human usage.
Anecdotal evidence suggests that there are no negative health effects attributed to simply trying the substance by itself at low to moderate doses and using it very sparingly (but nothing can be completely guaranteed). Independent research should always be done to ensure that a combination of two or more substances is safe before consumption.
Methallylescaline is not habit-forming, and the desire to use it can actually decrease with use. It is most often self-regulating.
Tolerance to the effects of methallylescaline is built almost immediately after ingestion. After that, it takes about 3 days for the tolerance to be reduced to half and 7 days to be back at baseline (in the absence of further consumption). Methallylescaline presents cross-tolerance with [[Cross-tolerance::all psychedelics]], meaning that after the consumption of methallylescaline all psychedelics will have a reduced effect.
As such, it may contain incomplete or wrong information. You can help by expanding it.
Canada: Methallylescaline is not listed under the Controlled Drugs and Substances Act, so it is technically not illegal.[citation needed]
Germany: Methallylescaline is controlled under the NpSG[2] (New Psychoactive Substances Act) as of November 26, 2016.[3] Production and import with the aim to place it on the market, administration to another person, placing it on the market and trading is punishable. Possession is illegal but not punishable.[4][5] The legislator considers it possible that orders of methallylescaline are punishable as an incitement to place it on the market.[6]
Switzerland: Methallylescaline is a controlled substance specifically named under Verzeichnis E.[7]
United Kingdom: Methallylescaline is illegal to produce, supply, or import under the Psychoactive Substance Act, which came into effect on May 26th, 2016.[8]
United States: Methallylescaline is unscheduled in the United States, but may be considered an analogue of mescaline under the Federal Analogue Act.[citation needed]
