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WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section.
DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.
Gaboxadol (also knows as THIP, OV101 and LU-2-030) is a depressant substance of the 3-hydroxyisoxazole class that produces sedative, anxiolytic, hypnotic and distinct hallucinogenic effects. It is chemically related to muscimol, which is the primary alkaloid responsible for the psychoactive effects of amanita muscaria. It has been specifically developed alongside hundreds of other analogs to display more pronounced and selective therapeutic effects as well as a higher bioavailability than its parent compound muscimol.[citation needed]
It was first synthesized in 1977 by the Danish chemist Povl Krogsgaard-Larsen. Since then it was subject to numerous medical evaluations for potential applications as an anxiolytic and hypnotic as well as treating conditions such as Alzheimer's disease among others. It's latest attempt at clinical trials was for the treatment of insomnia, although the trials have been cancelled.[2][3]
According to its pharmacological action, it is among a few hypnotic substances that do not negatively alter or suppress sleep and sleep architecture. It increases stage 4 deep sleep[4] and simultaneously does not inhibit REM sleep,[citation needed] this is a trait currently unique to Gaboxadol and some related GABAergics such as pregabalin[citation needed], GHB[citation needed] or cinazepam.[citation needed]
In high doses, Gaboxadol produces distinct deliriant effects but not in the manner of traditional deliriants. It can be categorized as a "GABAergic deliriant". It is said to have similar effects to muscimol and zolpidem.
Gaboxadol, also known as 4,5,6,7-tetrahydroisoxazolo(5,4-c)pyridin-3-ol (THIP), is a conformationally constrained derivative of the alkaloid muscimol.
Pharmacology
Gaboxadol acts on the GABA system, but in a different way from benzodiazepines and other GABAergic depressants. Lundbeck states that gaboxadol also increases deep sleep (stage 4).[5]
Subjective effects
Disclaimer: The effects listed below cite the Subjective Effect Index (SEI), an open research literature based on anecdotal user reports and the personal analyses of PsychonautWikicontributors. As a result, they should be viewed with a healthy degree of skepticism.
It is also worth noting that these effects will not necessarily occur in a predictable or reliable manner, although higher doses are more liable to induce the full spectrum of effects. Likewise, adverse effects become increasingly likely with higher doses and may include addiction, severe injury, or death ☠.
Physical effects
Sedation - Many users report mild to extreme sedation and even sleepiness or half-awake states while under the influence of Gaboxadol.
Cognitive euphoria - This results in feelings of physical euphoria which range between mild pleasure to powerfully all-encompassing bliss.
Decreased libidoorIncreased libido - Many users of Gaboxadol report to experience a noticeable decrease in libido while others report the opposite.
Dream potentiation - Many people fall asleep before the prominent effects take effect. These individuals report extremely vivid and often lucid dreams.
Auditory hallucination - While a wide array of auditory hallucinations are possible, many users report hearing a strange, comforting, omnipresent humming sound.
This toxicity and harm potential section is a stub.
As a result, it may contain incomplete or even dangerously wrong information! You can help by expanding upon or correcting it. Note: Always conduct independent research and use harm reduction practices if using this substance.
Gaboxadol is not known to be addictive or dependence-forming, and reports even show that desire to redose goes down with usage, though there is no research on this topic.
. PMC 6622081