Experience:U-47700 intermittent binges
- Substance: U-47700
- Dose: 20 - 120 mg / 90 minutes for approximately three days
- Route of Administration: Rectal
Subject
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- Age: 37
- Sex: M
- Height: 188 cm / 74 inches
- Weight: 100 kg / 220 lb
- Date: Varied from 2017 - 2018
- Location: Chile, Coquimbo
Background
Extensive experience with prescription opioids due to Crohn's Disease. (In 2010, 100 mg of hydromorphone / day, and after major intestinal resection, up to 200 mg / day. Methadone detox when no longer necessary to discontinuation in 2014.) At time of experiment, occasional binges of tramadol, 500 mg up to three times a day with minimal effects due to CYP4502D6 weak mutation. Daily alprazolam (2-4 mg), reduced during U-47700 use to 1 mg / day. Having gone through opioid withdrawal many times, I find my opioid withdrawal is generally quite atypical: I do not get restless legs nor do I feel more than minor pain, even when cold turkey discontinuing 25 mg of methadone / day or 32 mg of buprenorphine (without suboxone) / day. Instead, I tend to get very weepy, sweaty, and uncomfortable, and my libido - which is generally very low - increases dramatically. For the purposes of RoA, it is probably important to know that I have an ileostomy.
Experience report
During the period of 2017 - 2018, I would, usually once every two months, order 3g of U-47700 from a reputable vendor. While the physical addiction remained low after detox, the psychological addiction was extremely high: when I knew U-47700 was on its way to me, I would salivate profusely and sweat heavily.
Upon receipt of 3g of U-47700, I would dose approximately every 90 minutes rectally by weighing and dissolving in warm water and then using an oral syringe. Initial dose was 20 mg, and would gradually increase over the three days to 100 - 120 mg / 90 minutes. Sleep was minimal because I would force myself to stay awake as much as possible to enjoy the effects.
During the first 24 hours, I would typically be likely on the verge of overdose, vomiting profusely approximately halfway between doses. The effects consisted of incredibly intense euphoria, increased energy, hypomania, and intense itching. Due to Crohn's Disease, my energy levels are typically very low and I spend much of my time in bed. While on a U-47700 binge, I would pace continuously up and down the hall naked with a long handled showering brush, aggressively scratching all over my body, the feeling of which was delightful.
After the first night, my eyes would be very crusty. Despite rinsing with water and using eye drops, it was difficult to see clearly and my eyelids would crust over again, making it challenging to open fully.
During the following 24 hours, the vomiting had stopped, but I would typically underestimate the effects of the U-47700 since the euphoria began to increase despite dosage increases, which led me to have unjustified confidence in my ability to engage in activities that were risky, especially with my reduced vision. I refrained from driving but having been exercising near daily for the former year to lose weight gained from long-term prednisone use, I would swim 1.25 km most mornings and jog 5 km most nights.
One morning in particular, I tried to swim on U-47700, which was nearly impossible. I was living in a diplomatic compound in Chile where we had a private pool that I was the only one that used in early mornings, so I was not concerned with anyone noticing my altered state: however, I could not swim in a straight line and kept finding myself turned around or colliding with the opposite diagonal corner of the pool. Trying to count my laps was futile. I am fairly certain that I almost lost consciousness several times and was at significant risk of drowning.
One evening, I tried to at least walk my 5 km. I made it about 100 m from the gate to the diplomatic compound into the city proper where my balance was so poor that I felt I would stumble accidentally into the road or lose consciousness, so I immediately returned home.
I somehow managed to work through this time (software development) without my coworkers knowing how intoxicated I was. I lived a two minute walk to my house, so I would return home approximately every 90 minutes to redose, or bring pre-filled oral syringes with me to dose in my private office. My productivity was low during this time, but it went unnoticed.
By the third day, even large doses of 80 - 120 mg would barely intoxicate me, keeping me just at baseline. My eyes continued to be crusted shut and due to my intentional resistance to sleep, I was exhausted.
Upon running out, acute, intense withdrawal would set in within about three hours of my last dose. This could be mitigated with large doses of MT-45 (a horrible substance which felt as if it had kappa-opioid affinity and caused unpleasant dissociation) or tramadol that I had stocked up, which I would take for perhaps two days, and then experience no noticeable withdrawal apart from some depression.
On one occasion, I did not plan accordingly, and had no MT-45 or tramadol upon discontinuing. The 24 hours after my final dose were some of the most uncomfortable I have ever experienced: profuse sweating to the point that my sheets were soaked, and trying to walk was very difficult because my vision was swimming and my sense of balance was greatly reduced. I managed to sleep through most of the first 24 hours with doses of 4 mg of alprazolam and 100 mg of diphenhydramine every eight hours, and by the second day, the withdrawal had reduced greatly. By the third day, there was very little noticeable withdrawal and I could function relatively normally. By the fourth day, I was fully recovered.
Many people have said that they have found this compound corrosive, but despite the many rectal administrations over such a short period of time, I felt no corrosiveness and a colonoscopy during this period revealed that my colon looked healthy. Compare this to my one attempt to rectally administer 50 mg of 2C-C many years earlier, which was some of the most agonizing pain I have experienced.
I have never taken a substance that was so tolerance building and led to full-blown addiction in such a short time. I realize that my use was completely out of control and I felt powerless to it: on one occasion, for example, I asked my partner to hide 1.5 g so that I could binge 1.5 g over perhaps two days, allow my tolerance to reduce, and then repeat two to three weeks later. I ran out in the middle of the night, and after unsuccessfully looking for where the remaining 1.5 g had been hidden, I found myself shaking my partner awake, screaming and demanding the remaining 1.5 g. He did not want to deal with me in that completely irrational and desperate state, so he told me where he had placed the 1.5 g.
I must say that when U-47700 disappeared from the online vendors, I was relieved, because it could have easily led to me losing my prestigious job or even my life.
As an interesting addendum: I tend not to have an addictive personality and find it quite easy to discontinue substance use when it starts to become problematic with the exception of opioids. My partner, on the other hand, has a highly addictive personality and if beginning any substance, will quickly end up psychologically and possibly physically addicted. U-47700, for him, however, was the exception: he tried it five times, and while he enjoyed the experience, he did not feel any particular desire to repeat it.
Submitted by vorpal
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