Doxepin
Doxepin (trade name Silenor) is a sleep aid and tricyclic antidepressant with powerful hypnotic-like sedation at lower doses, while higher doses generally provide a stimulating antidepressant effect.
its' effects mainly stem from the antagonism, or blocking of the neurotransmitters adrenaline, serotonin, dopamine, histamine & acetylcholine, while inhibiting the reuptake of norepinephrine. Doxepin is prescribed to relieve allergic reactions, anxiety and depression, hives and insomnia.
Doxepin is a potent antihistamine and anticholinergic. This can lead to unwanted side effects, such as confusion, restless legs syndrome and delirium. Doxepin is also a voltage-gated sodium channel blocker, which poses lethal risk in the case of overdose. It should never be taken in combination with other sedatives, such as Alcohol and benzodiazepines, as it not only promotes sleep, but is capable of increasing the chances of an overdose, deliriant psychosis or serotonin syndrome.
Generally, insomnia is treated with dosages ranging from 5-30mg[1] ,while 75+ mg increase noradrenaline levels, preventing anxiety and some types of depression.
Because of minimal euphoria and "medicine hangovers", Doxepin is not a widely abused prescription drug. Doxepin can be classified as both an antidepressant and a deliriant.
The effects of Doxepin can be described as a "dulling" of the mental facilities, with a feeling of sedation similar to other recreational antihistamines, such as Diphenhydramine, Promethazine, or Doxylamine. Attempting to fight this effect can lead to the feeling of extreme sleep deprivation, as well as increase the chance for a headache. At high doses, the reuptake of noradrenaline usually makes it impossible to fall asleep.
