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WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section.
DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.
It may contain incorrect information, particularly with respect to dosage, duration, subjective effects, toxicity and other risks. It may also not meet PW style and grammar standards.
3,5-Dimethoxy-4-propoxyamphetamine (also known as 3C-P or 3C-Proscaline) is a lesser-known psychedelic substance of the amphetamine class. Although its name suggests it may be related to the 2C-x family, this is not the case since it is the 3-Carbon analog of proscaline.
The original synthesis date of 3C-P is unknown. Its theoretical synthesis is briefly mentioned in Alexander Shulgin's book PiHKAL, in which it is speculated to have psychedelic properties and a presumed dosage range of 20 to 40 milligrams.[1] It is typically sold on the online research chemical market.
Very little data exists about the pharmacological properties, metabolism, and toxicity of 3C-P, and it has only a brief history of human usage. It is highly advised to use harm reduction practices if using this substance.
3C-P or 3,5-Dimethoxy-4-propoxyamphetamine, is a molecule of the substituted amphetamine class. Amphetamines are substituted phenethylamines containing a phenyl ring bound to an amino (NH2) group through an ethyl chain and a methyl group bound to the alpha carbon Rα. 3C-P contains methoxy functional groups OCH3 attached to carbons R3 and R5 and a propoxy chain OCH2CH2CH3 attached to carbon R4 of the phenyl ring.
Although its name suggests it may be related to the 2C-x family, this is not the case. 3C-P is actually the 3-Carbon analog of proscaline, thus the name.
Its pharmacology can provide strong interaction with 5-HT2A receptors, which could potentially help to prevent cluster headaches or give the compound the possibility to ease the psychological suffering associated with end-stage cancer.
3C-P's psychedelic effects are believed to come from its efficacy at the 5-HT2A receptor as a partial agonist. However, the role of these interactions and how they result in the psychedelic experience continues to remain elusive.
According to the structure-activity-relationship between mescaline analogues, 3C-P has been identified as being more potent than mescaline and TMA-2. It has similar potency in animal studies to 3C-E, and the authors of one study on potency of mescaline analogues in rats predict that it may have similar effects and dosage to 3C-E.[2]
Subjective effects
Disclaimer: The effects listed below cite the Subjective Effect Index (SEI), an open research literature based on anecdotal user reports and the personal analyses of PsychonautWikicontributors. As a result, they should be viewed with a healthy degree of skepticism.
It is also worth noting that these effects will not necessarily occur in a predictable or reliable manner, although higher doses are more liable to induce the full spectrum of effects. Likewise, adverse effects become increasingly likely with higher doses and may include addiction, severe injury, or death ☠.
Physical effects
Stimulation - In terms of its effects on the physical energy levels of the user, 3C-P is usually considered to be moderately to extremely stimulating. In comparison, other more commonly used psychedelics such as psilocin are sedating and relaxed.
Seizure - This is likely a rare effect but may occur in those who are predisposed to them, especially while in physically taxing conditions such as being dehydrated, undernourished, overheated, or fatigued.[citation needed]
The visual geometry encountered on 3C-P can be described as similar in appearance to that of LSD, 2C-B and 2C-I.
The geometry can be comprehensively described as synthetic in style, algorithmic in appearance, intricate in complexity, structured in organization, fast in speed, smooth in motion, small in appearance, multicolored in scheme, glossy in color, and sharp and angular in its corners.
Level 8B - While the geometry produced by 3C-P has yet to be fully characterized, the geometry gives off certain attributes which are significantly more likely to result in states of level 8A visual geometry over level 8B at higher doses.
Hallucinatory states
3C-P and other substituted amphetamines produce a full range of high-level hallucinatory states in a fashion that is more consistent and reproducible than that of many other commonly used psychedelics. This holds particularly true in comparison to other substances within the phenethylamine family. These effects include:
The cognitive effects of 3C-P are described as primarily stimulating than psychedelic and more confusing than 3C-E, especially at higher dosages. The total sum of these cognitive components regardless of the setting generally includes:
Synaesthesia - In its fullest manifestation, this is a very rare and non-reproducible effect. Increasing the dosage can increase the likelihood of this occurring, but seems only to be a prominent part of the experience among those who are already predisposed to synaesthetic states.
There are currently 0 experience reports describing the effects of this substance in our experience index. You can also submit your own experience report using the same link.
This toxicity and harm potential section is a stub.
As a result, it may contain incomplete or even dangerously wrong information! You can help by expanding upon or correcting it. Note: Always conduct independent research and use harm reduction practices if using this substance.
The toxicity and long-term health effects of recreational 3C-P use do not seem to have been studied in any scientific context and the exact toxic dose is unknown. This is because 3C-P is a research chemical with very little history of human usage.
Anecdotal evidence from people within the community who have tried 3C-P suggests that there are no negative health effects attributed to simply trying it by itself at low to moderate doses and using it very sparingly (but nothing can be completely guaranteed). Independent research should always be done to ensure that a combination of two or more substances is safe before consumption.
3C-P is not habit-forming, and the desire to use it can actually decrease with use. It is most often self-regulating.
Tolerance to the effects of 3C-P is built almost immediately after ingestion. After that, it takes about 3 days for the tolerance to be reduced to half and 7 days to be back at baseline (in the absence of further consumption). 3C-P presents cross-tolerance with [[Cross-tolerance::all psychedelics]], meaning that after the consumption of 3C-P all psychedelics will have a reduced effect.
Dangerous interactions
Warning:Many psychoactive substances that are reasonably safe to use on their own can suddenly become dangerous and even life-threatening when combined with certain other substances. The following list provides some known dangerous interactions (although it is not guaranteed to include all of them).
Always conduct independent research (e.g. Google, DuckDuckGo, PubMed) to ensure that a combination of two or more substances is safe to consume. Some of the listed interactions have been sourced from TripSit.
[[Wikipedia:Lithium_(medication)|DangerousInteraction::Lithium]] - Lithium is commonly prescribed for the treatment of bipolar disorder. There is a large body of anecdotal evidence that suggests taking it with psychedelics significantly increases the risk of psychosis and seizures. As a result, this combination is strictly discouraged.
"[[UncertainInteraction" contains a listed "[" character as part of the property label and has therefore been classified as invalid.]] - Cannabis may have an unexpectedly strong and unpredictable synergy with the effects of 3C-P. Caution is advised with this combination as it can significantly increase the risk of adverse psychological reactions like anxiety, paranoia, panic attacks, and psychosis. Users are advised to start off with only a fraction of their normal cannabis dose and take long breaks between hits to avoid unintentional overdose.
"[[UnsafeInteraction" contains a listed "[" character as part of the property label and has therefore been classified as invalid.]] - Tramadol is well-documented to lower the seizure threshold[3] and psychedelics may act to trigger seizures in susceptible individuals.[citation needed]
As such, it may contain incomplete or wrong information. You can help by expanding it.
United Kingdom: It is illegal to produce, supply, or import this drug under the Psychoactive Substance Act, which came into effect on May 26th, 2016.[4]
United States: 3C-P is technically not scheduled in the United States, but could be considered an analog of mescaline and may, therefore, be considered a Schedule I drug under the Federal Analogue Act.
Japan: 3C-P is a controlled substance in Japan effective February 28th, 2018.[5]
↑Talaie, H.; Panahandeh, R.; Fayaznouri, M. R.; Asadi, Z.; Abdollahi, M. (2009). "Dose-independent occurrence of seizure with tramadol". Journal of Medical Toxicology. 5 (2): 63–67. doi:10.1007/BF03161089. ISSN1556-9039.
