This is an unofficial archive of PsychonautWiki as of 2025-08-11T15:14:44Z. Content on this page may be outdated, incomplete, or inaccurate. Please refer to the original page for the most up-to-date information.
expanded harm reduction, removed "personal experience for what is best for me" on dosage and re-dosing, removed missplaced links, added some links, rephrased some things
*'''[[Effects::Cognitive euphoria - Methcathinone is extremely stimulating and energetic.]]'''
*'''[[Effects::Cognitive euphoria]]''' - Methcathinone is extremely stimulating and energetic.
*'''[[Effects::Compulsive redosing]]'''
*'''[[Effects::Compulsive redosing]]'''
*'''[[Effect::Empathy, love, and sociability enhancement]]''' - This particular effect, although distinct, is far less prominent than the same effect found within traditional [[entactogens]] such as [[MDMA]] or [[2C-B]].
*'''[[Effect::Empathy, love, and sociability enhancement]]''' - This particular effect, although distinct, is far less prominent than the same effect found within traditional [[entactogens]] such as [[MDMA]] or [[2C-B]].
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===Neuro toxicity===
===Neuro toxicity===
Illicit methcathinone manufactured using potassium permanganate oxidation of [[ephedrine]] or [[pseudoephedrine]] has been connected with neurotoxicity caused by [https://en.wikipedia.org/wiki/Manganese manganese] poisoning.<ref>https://www.nejm.org/doi/full/10.1056/NEJMoa072488</ref>
Illicit methcathinone manufactured using potassium permanganate oxidation of [[ephedrine]] or [[pseudoephedrine]] has been connected with neurotoxicity caused by [https://en.wikipedia.org/wiki/Manganese manganese] poisoning.<ref>https://www.nejm.org/doi/full/10.1056/NEJMoa072488</ref>
===Dependence and abuse potential===
===Dependence and abuse potential===
Methcathinone, due to its highly addictive nature, can often cause extreme [[compulsive redosing]].
Methcathinone, due to its highly addictive nature, can often cause extreme [[compulsive redosing]].
It is strongly recommended that one use [[responsible drug use|harm reduction practices]] when using this substance.
It is strongly recommended that one use [[responsible drug use|harm reduction practices]] when using this substance.
===How to Dose Properly===.
====Dosing====
It is recommended to plan the total amount of Methcathinone you will take beforehand, how many times you are planning to redose and limit the amount you have accessible accordingly, to minimalize the risk of [[compulsive redosing]].
It is recommended to plan the total amount of Methcathinone you will take beforehand, how many times you are planning to redose and limit the amount you have accessible accordingly, to minimalize the risk of [[compulsive redosing]].
It may contain incorrect information, particularly with respect to dosage, duration, subjective effects, toxicity and other risks. It may also not meet PW style and grammar standards.
WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section.
DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.
Methcathinone (also known as Ephedrone originally, Methcat and CAT) is a synthetic stimulant substance of the cathinone chemical class. It produces standard amphetamine-like stimulant effects. It is similar to the cathinone compounds found in the khat plant of eastern Africa and mephedrone in its structure and effects.
Methcathinone was first synthesised in 1928 in the USA and it was used in the Soviet Union as an antidepressant. It is common in central and eastern Europe, often sold as the more well known mephedrone or synthesized from OTC drugs containing ephedrine or pseudoephedrine.
Methcathinone is comprised of a phenethylamine core featuring a phenyl ring bound to an amino (NH2) group through an ethyl chain containing a beta-ketone group (what is known as a cathinone molecule) with an additional methyl substitution at Rα. It can be thought of as the cathinone homolog of methamphetamine as it has the same general formula, differing only in the addition of a single double bonded oxygen.
Although the effects of methcathinone have not been formally studied on the same level as amphetamines, it is possible to speculate that like other simple substituted cathinone, it most likely acts primarily as a dopamine and norepinephrinereuptake inhibitor.[1] The result of this is an effective increase in the levels of the norepinephrine and dopamine neurotransmitters in the brain by binding to and partially blocking the transporter proteins that normally clear those monoamines from the synaptic cleft. This allows dopamine and norepinephrine to accumulate within the key area of the brain linked to reward and pleasure to extra-endogenous levels, resulting in stimulating, motivatory and euphoric effects.
Subjective effects
Disclaimer: The effects listed below cite the Subjective Effect Index (SEI), an open research literature based on anecdotal user reports and the personal analyses of PsychonautWikicontributors. As a result, they should be viewed with a healthy degree of skepticism.
It is also worth noting that these effects will not necessarily occur in a predictable or reliable manner, although higher doses are more liable to induce the full spectrum of effects. Likewise, adverse effects become increasingly likely with higher doses and may include addiction, severe injury, or death ☠.
Physical effects
Stimulation - Methcathinone is reported to be extremely stimulating and energetic. The style of stimulation can be described as "forced". This means that at higher doses, it becomes difficult or impossible to keep still as jaw clenching, involuntarily body shakes and vibrations become present.
Physical euphoria - Physical euphoria is very prominent when used responsibly (i.e. reasonable dosing and spacing between experiences) and can lead to profound feelings of social and physical disinhibition.
Dehydration - The Dehydration that is experienced during a methcathinone experience is generally more severe than with other stimulants like Amphetamine. Due to this, you must take extreme care and hydrate yourself constantly, so that you do not suffer from Rhabdomyolysis. This is done generally by observing your body, if there is any pain, if your kidneys feel weird, and if your urine is yellow to green-yellow like tea. Read the wiki and inform yourself on rhabdomyolysis since it is a very bad thing to have, you could die from it if it is severe enough and untreated over long time. Generally you can mitigate it by seeing if your urine is yellow, then if it is, and you do not urinate regularly drink a glass of water every 15 or 30 minutes (as long as you don't drink too much and hurt yourself) and your urine should become clear. As Long as you keep hydrating yourself your kidneys will be normal and functioning and you will be good, keep drinking water constantly after it becomes clear, for some few more hours but a bit less amount wise so that you don't have the problem again.
Increased heart rate - The increase in heart rate is generally weaker than with other stimulants like Methamphetamine.
Increased perspiration - The amount of perspiration is very high. You will sweat extremely easily in hot places and if you do any physical activity. Mixing Methcathinone with DXM will make you drip drops of sweat literally all the time. Hydrate yourself due to this increased perspiration or you will lose a large amount of water very fast.
Muscle contractions - These sudden muscle contractions are experienced during the comedown. This is due to the deficiency of Dopamine in the brain, which replicates symptoms to Parkinson's disease. These tremors are temporary and will subside within a few hours.
Muscle spasms - Typically occurs during the Comedown. This is due to depletion of Dopamine in the brain.
Spontaneous physical sensations - The "body high" of Methcathinone can be characterized as a moderate to extreme euphoric sensation that encompasses the entire body. It is capable of becoming overwhelmingly pleasurable at higher doses. This sensation maintains a consistent presence that steadily rises with the onset and hits its limit once the peak has been reached. -
Teeth grinding - This effect when experienced alongside euphoria can often lead to users mildly or intensely clenching their jaw muscles, sometimes even to the point where the individual’s facial expression begins to change. This is sometimes colloquially called “gurning”[4] and is typically only experienced in common to high dosages.
The cognitive effects of Methcathinone can be broken down into several components which progressively intensify proportional to dosage.
The most prominent of these cognitive effects generally include:
The effects which occur during the offset of a stimulant experience generally feel negative and uncomfortable in comparison to the effects which occurred during its peak. This is often referred to as a "comedown" and occurs because of neurotransmitter depletion. Its effects commonly include:
Illicit methcathinone manufactured using potassium permanganate oxidation of ephedrine or pseudoephedrine has been connected with neurotoxicity caused by manganese poisoning.[2]
Dependence and abuse potential
Methcathinone, due to its highly addictive nature, can often cause extreme compulsive redosing.
It is recommended to plan the total amount of Methcathinone you will take beforehand, how many times you are planning to redose and limit the amount you have accessible accordingly, to minimalize the risk of compulsive redosing.
Some people may also advice to tapper the comedown of a high dose, with a low dose after approximately an hour.
Synthesis
Methcathinone is synthesised most easily by reacting Pseudoephedrine with potassium permanganate, although dichromate may also be used as a oxidizer. The reaction is quite unstable and needs to be held at specifically -15 Celsious, so that the oxidation is subtle and not too energetic, turning Pseudoephedrine into Benzaldehyde. The same goes for the amount of potassium permanganate, it has to be a specific ratio of oxidizer to Pseudoephedrine.
