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'''3,5-Dimethoxy-4-ethoxyamphetamine''' (commonly known as '''3C-E''') is a synthetic [[psychoactive class::psychedelic]] compound of the [[chemical class::amphetamine|substituted amphetamine]] chemical class.
'''3,5-Dimethoxy-4-ethoxyamphetamine''' (commonly known as '''3C-E''' or '''3C-Escaline''') is a synthetic [[psychoactive class::psychedelic]] compound of the [[chemical class::Substituted amphetamines|amphetamine]] chemical class. Although it's name suggests it may be related to the [[2C-x]] family, this is not the case. 3C-E has the structure of [[escaline]], a mescaline analogue, with an additional carbon rendering it a substituted amphetamine.
Today, 3C-E is used as a [[recreational drug use|recreational drug]] and an [[entheogen]], probably non-existent on the streets and rarely found on grey area [[research chemical]] vendors.
3C-E was presumably first synthesized by [[Alexander Shulgin]] and published in his book [[PiHKAL]] in 1991.<ref>{{Citation | title=Erowid Online Books : “PIHKAL” - #25 3C-E | url=https://erowid.org/library/books_online/pihkal/pihkal025.shtml}}</ref>
<!-- Many reports also suggest that this substance may be overly difficult to use safely for those who are not already very experienced with [[hallucinogens]]. Therefore it is highly advised to approach this substance with the proper amount of precaution and [[harm reduction practices]] if choosing to use it. -->
Today, 3C-E is used for [[recreational drug use|recreational]] and research purposes, and exclusively distributed as a gray area [[research chemical]] by online vendors. Very little is known about its effects besides its strong body high and weak visuals.
==Chemistry==
==Chemistry==
3C-E or 3,5-Dimethoxy-4-ethoxyamphetamine, is a molecule of the [[substituted amphetamine]] class. Amphetamines are substituted phenethylamines containing a phenyl ring bound to an amino (NH<sub>2</sub>) group through an ethyl chain and a methyl group bound to the alpha carbon R<sub>α</sub>. 3C-E contains methoxy functional groups OCH<sub>3</sub> attached to carbons R<sub>3</sub> and R<sub>5</sub> and an ethoxy chain OCH<sub>2</sub>CH<sub>3</sub> attached to carbon R<sub>4</sub> of the phenyl ring. 3C-E is the amphetamine analogue of [[escaline]].
3C-E or 3,5-Dimethoxy-4-ethoxyamphetamine, is a molecule of the [[substituted amphetamine]] class. Amphetamines are substituted phenethylamines containing a phenyl ring bound to an amino (NH<sub>2</sub>) group through an ethyl chain and a methyl group bound to the alpha carbon R<sub>α</sub>. 3C-E contains methoxy functional groups OCH<sub>3</sub> attached to carbons R<sub>3</sub> and R<sub>5</sub> and an ethoxy chain OCH<sub>2</sub>CH<sub>3</sub> attached to carbon R<sub>4</sub> of the phenyl ring.
3C-E is the amphetamine analog of [[escaline]].
==Pharmacology==
==Pharmacology==
{{Further|Serotonergic psychedelic}}
{{Further|Serotonergic psychedelic}}
Although its name suggests it may be related to the 2C-x family, this is not the case. 3C-E is actually the 3-Carbon analog of escaline, thus the name.
Its pharmacology can provide strong interaction with 5-HT2A receptors, which could potentially help to prevent cluster headaches or give the compound the possibility to ease the psychological suffering associated with end-stage cancer.
3C-E's [[psychedelic]] effects are believed to come from its efficacy at the [[Serotonin#The 5-HT system|5-HT<sub>2A</sub> receptor]] as a [[Agonist#Agonists|partial agonist]]. However, the role of these interactions and how they result in the [[psychedelic]] experience continues to remain elusive.
3C-E's [[psychedelic]] effects are believed to come from its efficacy at the [[Serotonin#The 5-HT system|5-HT<sub>2A</sub> receptor]] as a [[Agonist#Agonists|partial agonist]]. However, the role of these interactions and how they result in the [[psychedelic]] experience continues to remain elusive.
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|{{effects/physical|
|{{effects/physical|
*'''[[Effect::Stimulation]]''' - In terms of its effects on the physical energy levels of the user, 3C-E is usually considered to be extremely stimulating at levels which are capable of become uncomfortable and overwhelming <!--(although it is considered to be relatively mellow in this respect compared to other [[DOx]] compounds such as [[DOI]] and [[DOB]])--> . This can result in a shakiness and unsteadiness of the hands but encouraging one to move around, run, dance, climb and generally engage in physical activities. In comparison, other more commonly used psychedelics such as [[psilocin]] are generally sedating and relaxed. -->
*'''[[Effect::Stimulation]]''' - In terms of its effects on the physical energy levels of the user, 3C-E is usually considered to be moderately to extremely stimulating. In comparison, other more commonly used psychedelics such as [[psilocin]] are sedating and relaxed.
*'''[[Effect::Spontaneous physical sensations]]''' - The "body high" of 3C-E is manifested as somewhat intense in comparison to most classical psychedelics such as [[LSD]]. The sensation itself can be described as a constantly present yet somewhat mild energetic pins and needles sensation that encompasses a person’s entire body. It is usually felt over every square inch of the skin, but occasionally manifests itself in the form of a continuously shifting tingling sensation that travels up and down the body in spontaneous waves.
*'''[[Effect::Spontaneous physical sensations]]''' - The "body high" of 3C-E is manifested as somewhat intense in comparison to most classical psychedelics such as [[LSD]]. The sensation itself can be described as a constantly present yet somewhat mild energetic pins and needles sensation that encompasses a person’s entire body. It is usually felt over every square inch of the skin but occasionally manifests itself in the form of a continuously shifting tingling sensation that travels up and down the body in spontaneous waves.
**'''[[Effect::Physical euphoria]]''' - It should be noted that this effect is not as reliably induceable as it is with substances like stimulants or entactogens, and can just as easily manifest as physical discomfort without any apparent reason.
**'''[[Effect::Physical euphoria]]''' - It should be noted that this effect is not as reliably induceable as it is with substances like stimulants or entactogens, and can just as easily manifest as physical discomfort without any apparent reason.
*'''[[Effect::Changes in felt bodily form]]''' <!-- - This effect is often accompanied by a sense of warmth or [[Unity and interconnectedness#Unity between the self and specific external systems|unity]] and usually occurs during and up to the peak of the experience or directly afterward. Users can feel as if they are physically part of or conjoined with other objects. This is usually reported as feeling comfortable in its sensations and even peaceful. -->
*'''[[Effect::Bodily control enhancement]]'''
*'''[[Effect::Bodily control enhancement]]'''
*'''[[Effect::Tactile enhancement]]''' - Feelings of enhanced tactile sensation are consistently present at low to moderate levels throughout most 3C-E experiences.
*'''[[Effect::Tactile enhancement]]''' - Feelings of enhanced tactile sensation are consistently present at low to moderate levels.
*'''[[Effect::Nausea]]''' - Mild to extreme nausea is reported when consumed in moderate to high dosages and either passes once the person has vomited or gradually fades by itself as the peak sets in.
*'''[[Effect::Nausea]]'''
<!-- *'''[[Effect::Vasoconstriction]]''' - This effect is usually only present at higher dosages, but can be particularly uncomfortable when it manifests, and may persist throughout the main duration of the experience. -->
*'''[[Effect::Seizure]]''' - This is a rarely observed effect but is known to happen in those who are presumably predisposed to them, especially while in physically taxing conditions such as being dehydrated, undernourished, overheated, or generally fatigued.{{citation needed}} [[Should we let this stay?]]
*'''[[Effect::Vasoconstriction]]'''
*'''[[Effect::Seizure]]''' - This is likely a rare effect but may occur in those who are predisposed to them, especially while in physically taxing conditions such as being dehydrated, undernourished, overheated, or fatigued.{{citation needed}}
}}
}}
{{effects/visual|
{{effects/visual|
The visuals of 3C-E are generally not that apparent and consist more so of distortions than colors and drifting.
====Enhancements====
====Enhancements====
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====Distortions====
====Distortions====
*'''[[Effect::Drifting]]''' ''([[Drifting#Melting|melting]], [[Drifting#Flowing|flowing]], [[Drifting#Breathing|breathing]] and [[Drifting# morphing|morphing]])'' - In comparison to other psychedelics, this effect can be described as highly detailed, slow and smooth in motion, static in appearance and unrealistic/cartoon-like in style. This effect is generally not as powerful as it is with substances like [[mescaline]] or [[DOC]].
*'''[[Effect::Drifting]]''' ''([[Drifting#Melting|melting]], [[Drifting#Flowing|flowing]], [[Drifting#Breathing|breathing]] and [[Drifting# morphing|morphing]])''
*'''[[Effect::Colour shifting]]'''
*'''[[Effect::Colour shifting]]'''
*'''[[Effect::Depth perception distortions]]'''
*'''[[Effect::Depth perception distortions]]'''
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*'''[[Effect::Brightness alteration]]'''
*'''[[Effect::Brightness alteration]]'''
*'''[[Effect::Diffraction]]'''
*'''[[Effect::Diffraction]]'''
[[must confirm all these????????]]
====[[Effect::Geometry]]====
====[[Effect::Geometry]]====
The visual geometry that is present throughout this trip can be described as more similar in appearance to that of [[DOC]] or [[mescaline]][[?]] than that of [[2C-B]], [[psilocin]] or [[LSD]]. It can be comprehensively described through its [[Visual_effects:_Geometry#Variations|variations]] as intricate in complexity, abstract in form, organic in feel, structured in organization, brightly lit, multicolored in scheme, glossy in shading, sharp in edges, large in size, fast in speed, smooth in motion, equally rounded and angular in its corners, non-immersive in depth and consistent in intensity. At higher dosages, this geometry is significantly more likely to result in states of [[Effect::8B Geometry|level 8B]] visual geometry over [[8A Geometry|level 8A]]. [[cant comment on 8a or 8b-geometry]] [[anyone else think the geometry is very similar to DOC?]]
The visual geometry that is present throughout this trip can be described as more similar in appearance to that of [[DOC]] or [[mescaline]] than that of [[2C-B]], [[psilocin]] or [[LSD]]. It can be comprehensively described through its [[Visual_effects:_Geometry#Variations|variations]] as intricate in complexity, abstract in form, synthetic in feel, structured in organization, brightly lit, multicolored in scheme, glossy in shading, sharp in edges, large in size, fast in speed, smooth in motion, equally rounded and angular in its corners, non-immersive in-depth and consistent in intensity.<!-- At higher dosages, this geometry is significantly more likely to result in states of [[Effect::8B Geometry|level 8B]] visual geometry over [[8A Geometry|level 8A]]. -->
====Hallucinatory states====
====Hallucinatory states====
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*'''[[Effect::Transformations]]'''
*'''[[Effect::Transformations]]'''
*'''[[Effect::Internal hallucinations]]''' (''[[effect::autonomous entities]]''; ''[[effect::settings, sceneries, and landscapes]]''; ''[[effect::Alterations in perspective]]'' and ''[[effect::scenarios and plots]]'') - In comparison to other [[psychedelic]]s such as [[LSD]], 3C-E is extremely high in internal hallucinations. They are more common within dark environments and can be comprehensibly described through its [[Internal_hallucinations#Variations|variations]] as lucid in believability, interactive in style, new experiences in content, autonomous in controllability, [[geometry]]-based in style and almost exclusively of a personal, religious, spiritual, science-fiction, fantasy, surreal, nonsensical or transcendental nature in their overall theme.
*'''[[Effect::Internal hallucination]]''' (''[[effect::autonomous entities]]''; ''[[effect::settings, sceneries, and landscapes]]''; ''[[effect::Alterations in perspective]]'' and ''[[effect::scenarios and plots]]'') - In comparison to other [[psychedelic]]s such as [[LSD]], 3C-E is extremely high in internal hallucinations. They are more common within dark environments and can be comprehensibly described through its [[Internal_hallucinations#Variations|variations]] as lucid in believability, interactive in style, new experiences in content, autonomous in controllability, [[geometry]]-based in style and almost exclusively of a personal, religious, spiritual, science-fiction, fantasy, surreal, nonsensical or transcendental nature in their overall theme.
*'''[[Effect:: External hallucinations]]''' - These are often present during the comedown and can include [[shadow people]], among other indescribable beings. These external hallucinations are often lucid, interactive, autonomous, and robust. As [[sleep deprivation]] and [[stimulant psychosis]] surface, a [[trip sitter]] should accompany individuals sensitive to stimulants for the last part of the comedown. The visual effects of psychosis have been reported to blend into the psychedelic visuals around the 5-8 [[insufflated]] [[?]] hour mark, sometimes accompanied by auditory hallucinations.
}}
}}
|{{effects/cognitive|
|{{effects/cognitive|
The cognitive effects of 3C-E are described by many as characterized as prominent mental stimulation combined with a powerful amplification of the user's current mental state.
The cognitive effects of 3C-E are described as primarily stimulating than psychedelic. Higher dosages can lead to a more likely occurence of confusion.
The total sum of these cognitive components regardless of the setting generally includes:
The total sum of these cognitive components regardless of the setting generally includes:
*'''[[Effect::Conceptual thinking]]'''
*'''[[Effect::Conceptual thinking]]'''
*'''[[Effect::Confusion]]'''
*'''[[Effect::Thought acceleration]]'''
*'''[[Effect::Thought acceleration]]'''
*'''[[Effect::Thought connectivity]]'''
*'''[[Effect::Thought connectivity]]'''
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*'''[[Effect::Empathy, affection, and sociability enhancement]]''' - This component is typically manifested only in the context of social settings in which one is within the company of others, and only at lower, non-impairing doses. These feelings of sociability, affection, and empathy tend to be weaker and less consistent than those produced by substances such as [[MDMA]] and [[2C-B]], but can still prove strong enough to provide long-lasting therapeutic effects.
*'''[[Effect::Empathy, affection, and sociability enhancement]]''' - This component is typically manifested only in the context of social settings in which one is within the company of others, and only at lower, non-impairing doses. These feelings of sociability, affection, and empathy tend to be weaker and less consistent than those produced by substances such as [[MDMA]] and [[2C-B]], but can still prove strong enough to provide long-lasting therapeutic effects.
*'''[[Effect::Cognitive euphoria]]'''
*'''[[Effect::Cognitive euphoria]]'''
*'''[[Effect::Analysis enhancement]]''' - [[This effect is consistent in its manifestation and [[outrospection]] dominant.]]
*'''[[Effect::Analysis enhancement]]''' - This effect is consistent in its manifestation and [[outrospection]] dominant.
*'''[[Effect::Personal bias suppression]]'''
*'''[[Effect::Personal bias suppression]]'''
*'''[[Effect::Novelty enhancement]]'''
*'''[[Effect::Novelty enhancement]]'''
*'''[[Effect::Immersion enhancement]]'''
*'''[[Effect::Immersion enhancement]]'''
*'''[[Effect::Emotionality enhancement]]'''
*'''[[Effect::Emotion enhancement]]'''
*'''[[Effect::Increased music appreciation]]'''
*'''[[Effect::Increased music appreciation]]'''
*'''[[Effect::Increased sense of humor]]'''
*'''[[Effect::Increased sense of humor]]'''
**'''[[Effect::Laughter fits]]''' - This can manifest prominently during a 3C-E experience, particularly during the [[Duration#Come up|come up]] phase, often resulting in bouts of uncontrollable giggles and laughter that can form a feedback loop if around others who are also under the influence.
**'''[[Effect::Laughter fits]]'''
*'''[[Effect::Memory suppression]]'''
*'''[[Effect::Memory suppression]]'''
**'''[[Effect::Ego death]]'''
**'''[[Effect::Ego death]]'''
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{{effects/multisensory|
{{effects/multisensory|
*'''[[Effect::Synaesthesia]]''' - In its fullest manifestation, this is a very rare and non-reproducible effect. Increasing the dosage can increase the likelihood of this occurring, but seems to only be a prominent part of the experience among those who are already predisposed to synaesthetic states.
*'''[[Effect::Synaesthesia]]''' - In its fullest manifestation, this is a very rare and non-reproducible effect. Increasing the dosage can increase the likelihood of this occurring, but seems only to be a prominent part of the experience among those who are already predisposed to synaesthetic states.
}}
}}
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}}
}}
}}
}}
===Experience reports===
===Experience reports===
There are currently no anecdotal reports which describe the effects of this compound within our [[experience index]].
{{further|Research chemicals#Toxicity and harm potential|Responsible use #Hallucinogens}}
{{further|Research chemicals#Toxicity and harm potential|Responsible use #Hallucinogens}}
The toxicity and long-term health effects of recreational 3C-E use do not seem to have been studied in any scientific context and the exact [[Toxicity::toxic dose is unknown]]. This is because 3C-E is a [[research chemical]] with very little history of human usage. Anecdotal evidence from people within the psychonaut community who have tried 3C-E suggests that there are no negative health effects attributed to simply trying the drug by itself at low to moderate doses and using it very sparingly (but nothing can be completely guaranteed). [https://www.google.com/ Independent research] should always be done to ensure that a combination of two or more substances is safe before consumption.
The toxicity and long-term health effects of recreational 3C-E use do not seem to have been studied in any scientific context and the exact [[Toxicity::toxic dose is unknown]]. This is because 3C-E is a [[research chemical]] with very little history of human usage.
Anecdotal evidence from people within the community who have tried 3C-E suggests that there are no negative health effects attributed to simply trying it by itself at low to moderate doses and using it very sparingly (but nothing can be completely guaranteed). [https://www.google.com/ Independent research] should always be done to ensure that a combination of two or more substances is safe before consumption.
It is strongly recommended that one use [[responsible drug use|harm reduction practices]] when using this substance.
It is strongly recommended that one use [[responsible drug use|harm reduction practices]] when using this substance.
===Tolerance and addiction potential===
===Tolerance and addiction potential===
3C-E is [[Addiction potential::not habit-forming]] and the desire to use it can actually decrease with use. It is most often self-regulating.
3C-E is [[Addiction potential::not habit-forming]], and the desire to use it can actually decrease with use. It is most often self-regulating.
Tolerance to the effects of 3C-E are built [[Time to full tolerance::almost immediately after ingestion]]. After that, it takes about [[Time to half tolerance::3 days]] for the tolerance to be reduced to half and [[Time to zero tolerance::7 days]] to be back at baseline (in the absence of further consumption). 3C-E presents cross-tolerance with [[Cross-tolerance::all [[psychedelic]]s]], meaning that after the consumption of 3C-E all psychedelics will have a reduced effect. [[Not sure about this one since amphetamine psychedelics like 2c-b, 2c-e and DOC (or 2c-p after ~300-400ug Lsd)dont build an immediate tolerance, if even any at all]]
Tolerance to the effects of 3C-E is built [[Time to full tolerance::almost immediately after ingestion]]. After that, it takes about [[Time to half tolerance::3 days]] for the tolerance to be reduced to half and [[Time to zero tolerance::7 days]] to be back at baseline (in the absence of further consumption). 3C-E presents cross-tolerance with [[Cross-tolerance::all [[psychedelic]]s]], meaning that after the consumption of 3C-E all psychedelics will have a reduced effect.
===Dangerous interactions===
===Dangerous interactions===
{{DangerousInteractions}}
{{DangerousInteractions/Intro}}
{{DangerousInteractions/Psychedelics}}
Although many substances are safe on their own, they can become dangerous and even life-threatening when combined with other substances. The list below contains some common potentially dangerous combinations, but may not include all of them. Certain combinations may be relatively harmless in low doses of each but can still increase the risk of unpredictable injury or death. [https://www.google.com/ Independent research] should always be done to ensure that a combination of two or more substances is safe before consumption.
*'''[[Tramadol]]''' - Tramadol lowers the seizure threshold<ref>Talaie, H., Panahandeh, R., Fayaznouri, M. R., Asadi, Z., & Abdollahi, M. (2009). Dose-independent occurrence of seizure with tramadol. Journal of medical toxicology, 5(2), 63-67. doi:10.1007/BF03161089</ref> and [[psychedelics]] may act as triggers for seizures, particularly in those who are predisposed to them.{{citation needed}}
==Legal status==
*'''[[Stimulants]]''' - Stimulants affect many parts of the brain. Combined with psychedelics, stimulation can turn into uncontrollable [[anxiety]], [[Panic attacks|panic]], [[thought loops]] and [[paranoia]]. This interaction may cause elevated risk of psychosis.{{citation needed}}
*'''[https://en.wikipedia.org/wiki/Lithium_(medication) Lithium]''' - Lithium is often used as treatment for bipolar disorder. It may possibly cause elevated risk of seizures and psychosis due to its [[Glutamate|glutaminergic]] and [[GABA|GABAergic]] effects.{{citation needed}}
*'''United States:''' 3C-E is technically not scheduled in the United States, but could be considered an analogue of [[mescaline]][[?]] and may therefore be considered a Schedule I drug under the Federal Analogue Act.
*'''Germany''': 3C-E is controlled under the NpSG (New Psychoactive Substances Act) as of November 26, 2016.<ref>{{cite web|url=https://www.bgbl.de/xaver/bgbl/start.xav?startbk=Bundesanzeiger_BGBl&jumpTo=bgbl116s2615.pdf#__bgbl__%2F%2F*%5B%40attr_id%3D%27bgbl116s2615.pdf%27%5D__1576017393518|title=Gesetz zur Bekämpfung der Verbreitung neuer psychoaktiver Stoffe|publisher=Bundesanzeiger Verlag|access-date=December 11, 2019|language=de}}</ref><ref>{{cite web|url=https://www.gesetze-im-internet.de/npsg/anlage.html|title=Anlage NpSG|publisher=Bundesministerium der Justiz und für Verbraucherschutz|access-date=December 11, 2019|language=de}}</ref> Production and import with the aim to place it on the market, administration to another person and trading is punishable. Possession is illegal but not penalized.<ref>{{cite web|url=https://www.gesetze-im-internet.de/npsg/__4.html|title=§ 4 NpSG|publisher=Bundesministerium der Justiz und für Verbraucherschutz|access-date=December 11, 2019|language=de}}</ref>
*'''Japan''': 3C-E is a controlled substance in Japan effective March 25th, 2015.<ref>{{Citation | title=危険ドラッグの成分１６物質を新たに指定薬物に指定 | publisher=厚生労働省 [Ministry of Health, Labour and Welfare (MHLW)] | language=japanese | url=https://www.mhlw.go.jp/stf/houdou/0000078803.html | access-date=2 May 2022}}</ref>
*'''Switzerland''': 3C-E can be considered a controlled substance as a defined derivative of a-methylphenethylamine under Verzeichnis E point 130. It is legal when used for scientific or industrial use.<ref>{{cite web|url=https://www.admin.ch/opc/de/classified-compilation/20101220/index.html|title=Verordnung des EDI über die Verzeichnisse der Betäubungsmittel, psychotropen Stoffe, Vorläuferstoffe und Hilfschemikalien|publisher=Bundeskanzlei [Federal Chancellery of Switzerland]|access-date=January 1, 2020|language=de}}</ref>
*'''United Kingdom''': It is illegal to produce, supply, or import this drug under the Psychoactive Substance Act, which came into effect on May 26th, 2016.<ref>{{Citation | title=Psychoactive Substances Act 2016 | url=https://www.legislation.gov.uk/ukpga/2016/2/contents/enacted}}</ref>
*'''United States''': 3C-E is technically not scheduled in the United States, but could be considered an analog of [[mescaline]] and may, therefore, be considered a Schedule I drug under the Federal Analogue Act.
WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section.
DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.
3,5-Dimethoxy-4-ethoxyamphetamine (commonly known as 3C-E or 3C-Escaline) is a synthetic psychedelic compound of the amphetamine chemical class. Although it's name suggests it may be related to the 2C-x family, this is not the case. 3C-E has the structure of escaline, a mescaline analogue, with an additional carbon rendering it a substituted amphetamine.
Today, 3C-E is used for recreational and research purposes, and exclusively distributed as a gray area research chemical by online vendors. Very little is known about its effects besides its strong body high and weak visuals.
3C-E or 3,5-Dimethoxy-4-ethoxyamphetamine, is a molecule of the substituted amphetamine class. Amphetamines are substituted phenethylamines containing a phenyl ring bound to an amino (NH2) group through an ethyl chain and a methyl group bound to the alpha carbon Rα. 3C-E contains methoxy functional groups OCH3 attached to carbons R3 and R5 and an ethoxy chain OCH2CH3 attached to carbon R4 of the phenyl ring.
Although its name suggests it may be related to the 2C-x family, this is not the case. 3C-E is actually the 3-Carbon analog of escaline, thus the name.
Its pharmacology can provide strong interaction with 5-HT2A receptors, which could potentially help to prevent cluster headaches or give the compound the possibility to ease the psychological suffering associated with end-stage cancer.
3C-E's psychedelic effects are believed to come from its efficacy at the 5-HT2A receptor as a partial agonist. However, the role of these interactions and how they result in the psychedelic experience continues to remain elusive.
Subjective effects
Disclaimer: The effects listed below cite the Subjective Effect Index (SEI), an open research literature based on anecdotal user reports and the personal analyses of PsychonautWikicontributors. As a result, they should be viewed with a healthy degree of skepticism.
It is also worth noting that these effects will not necessarily occur in a predictable or reliable manner, although higher doses are more liable to induce the full spectrum of effects. Likewise, adverse effects become increasingly likely with higher doses and may include addiction, severe injury, or death ☠.
Physical effects
Stimulation - In terms of its effects on the physical energy levels of the user, 3C-E is usually considered to be moderately to extremely stimulating. In comparison, other more commonly used psychedelics such as psilocin are sedating and relaxed.
Spontaneous physical sensations - The "body high" of 3C-E is manifested as somewhat intense in comparison to most classical psychedelics such as LSD. The sensation itself can be described as a constantly present yet somewhat mild energetic pins and needles sensation that encompasses a person’s entire body. It is usually felt over every square inch of the skin but occasionally manifests itself in the form of a continuously shifting tingling sensation that travels up and down the body in spontaneous waves.
Physical euphoria - It should be noted that this effect is not as reliably induceable as it is with substances like stimulants or entactogens, and can just as easily manifest as physical discomfort without any apparent reason.
Seizure - This is likely a rare effect but may occur in those who are predisposed to them, especially while in physically taxing conditions such as being dehydrated, undernourished, overheated, or fatigued.[citation needed]
Visual effects
The visuals of 3C-E are generally not that apparent and consist more so of distortions than colors and drifting.
The visual geometry that is present throughout this trip can be described as more similar in appearance to that of DOC or mescaline than that of 2C-B, psilocin or LSD. It can be comprehensively described through its variations as intricate in complexity, abstract in form, synthetic in feel, structured in organization, brightly lit, multicolored in scheme, glossy in shading, sharp in edges, large in size, fast in speed, smooth in motion, equally rounded and angular in its corners, non-immersive in-depth and consistent in intensity.
Hallucinatory states
3C-E and other substituted amphetamines produce a full range of high-level hallucinatory states in a fashion that is more consistent and reproducible than that of many other commonly used psychedelics. This holds particularly true in comparison to other substances within the phenethylamine family. These effects include:
Internal hallucination (autonomous entities; settings, sceneries, and landscapes; Alterations in perspective and scenarios and plots) - In comparison to other psychedelics such as LSD, 3C-E is extremely high in internal hallucinations. They are more common within dark environments and can be comprehensibly described through its variations as lucid in believability, interactive in style, new experiences in content, autonomous in controllability, geometry-based in style and almost exclusively of a personal, religious, spiritual, science-fiction, fantasy, surreal, nonsensical or transcendental nature in their overall theme.
Cognitive effects
The cognitive effects of 3C-E are described as primarily stimulating than psychedelic. Higher dosages can lead to a more likely occurence of confusion.
The total sum of these cognitive components regardless of the setting generally includes:
Anxiety & Paranoia - This effect is not as common at low to moderate doses and is less likely to occur when the basic rules of set and setting are taken into account. It should be noted that this inconsistently induced effect is seemingly more likely to manifest when used with cannabis. This combination should be used with extreme caution if one is not experienced with psychedelics, meaning that the user should adequately pace themselves with a fraction of their usual amount. It is commonly reported that psychedelics can to a certain extent counteract some of the perceived mental cloudiness or intoxicating effects of THC causing the user to in turn use more cannabis than is needed which can often lead to an overwhelmingly anxious and paranoid headspace which can trigger a "bad trip".
Empathy, affection, and sociability enhancement - This component is typically manifested only in the context of social settings in which one is within the company of others, and only at lower, non-impairing doses. These feelings of sociability, affection, and empathy tend to be weaker and less consistent than those produced by substances such as MDMA and 2C-B, but can still prove strong enough to provide long-lasting therapeutic effects.
Synaesthesia - In its fullest manifestation, this is a very rare and non-reproducible effect. Increasing the dosage can increase the likelihood of this occurring, but seems only to be a prominent part of the experience among those who are already predisposed to synaesthetic states.
There are currently 0 experience reports describing the effects of this substance in our experience index. You can also submit your own experience report using the same link.
This toxicity and harm potential section is a stub.
As a result, it may contain incomplete or even dangerously wrong information! You can help by expanding upon or correcting it. Note: Always conduct independent research and use harm reduction practices if using this substance.
The toxicity and long-term health effects of recreational 3C-E use do not seem to have been studied in any scientific context and the exact toxic dose is unknown. This is because 3C-E is a research chemical with very little history of human usage.
Anecdotal evidence from people within the community who have tried 3C-E suggests that there are no negative health effects attributed to simply trying it by itself at low to moderate doses and using it very sparingly (but nothing can be completely guaranteed). Independent research should always be done to ensure that a combination of two or more substances is safe before consumption.
3C-E is not habit-forming, and the desire to use it can actually decrease with use. It is most often self-regulating.
Tolerance to the effects of 3C-E is built almost immediately after ingestion. After that, it takes about 3 days for the tolerance to be reduced to half and 7 days to be back at baseline (in the absence of further consumption). 3C-E presents cross-tolerance with [[Cross-tolerance::all psychedelics]], meaning that after the consumption of 3C-E all psychedelics will have a reduced effect.
Dangerous interactions
Warning:Many psychoactive substances that are reasonably safe to use on their own can suddenly become dangerous and even life-threatening when combined with certain other substances. The following list provides some known dangerous interactions (although it is not guaranteed to include all of them).
Always conduct independent research (e.g. Google, DuckDuckGo, PubMed) to ensure that a combination of two or more substances is safe to consume. Some of the listed interactions have been sourced from TripSit.
[[Wikipedia:Lithium_(medication)|DangerousInteraction::Lithium]] - Lithium is commonly prescribed for the treatment of bipolar disorder. There is a large body of anecdotal evidence that suggests taking it with psychedelics significantly increases the risk of psychosis and seizures. As a result, this combination is strictly discouraged.
"[[UncertainInteraction" contains a listed "[" character as part of the property label and has therefore been classified as invalid.]] - Cannabis may have an unexpectedly strong and unpredictable synergy with the effects of 3C-E. Caution is advised with this combination as it can significantly increase the risk of adverse psychological reactions like anxiety, paranoia, panic attacks, and psychosis. Users are advised to start off with only a fraction of their normal cannabis dose and take long breaks between hits to avoid unintentional overdose.
"[[UnsafeInteraction" contains a listed "[" character as part of the property label and has therefore been classified as invalid.]] - Tramadol is well-documented to lower the seizure threshold[2] and psychedelics may act to trigger seizures in susceptible individuals.[citation needed]
As such, it may contain incomplete or wrong information. You can help by expanding it.
Germany: 3C-E is controlled under the NpSG (New Psychoactive Substances Act) as of November 26, 2016.[3][4] Production and import with the aim to place it on the market, administration to another person and trading is punishable. Possession is illegal but not penalized.[5]
Japan: 3C-E is a controlled substance in Japan effective March 25th, 2015.[6]
Switzerland: 3C-E can be considered a controlled substance as a defined derivative of a-methylphenethylamine under Verzeichnis E point 130. It is legal when used for scientific or industrial use.[7]
United Kingdom: It is illegal to produce, supply, or import this drug under the Psychoactive Substance Act, which came into effect on May 26th, 2016.[8]
United States: 3C-E is technically not scheduled in the United States, but could be considered an analog of mescaline and may, therefore, be considered a Schedule I drug under the Federal Analogue Act.
↑Talaie, H.; Panahandeh, R.; Fayaznouri, M. R.; Asadi, Z.; Abdollahi, M. (2009). "Dose-independent occurrence of seizure with tramadol". Journal of Medical Toxicology. 5 (2): 63–67. doi:10.1007/BF03161089. ISSN1556-9039.
↑"Anlage NpSG" (in Deutsch). Bundesministerium der Justiz und für Verbraucherschutz. Retrieved December 11, 2019.
↑"§ 4 NpSG" (in Deutsch). Bundesministerium der Justiz und für Verbraucherschutz. Retrieved December 11, 2019.
↑危険ドラッグの成分１６物質を新たに指定薬物に指定 (in japanese), 厚生労働省 [Ministry of Health, Labour and Welfare (MHLW)], retrieved 2 May 2022CS1 maint: Unrecognized language (link)
