Rhodocollybia maculata
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| Rhodocollybia maculata | |
|---|---|
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| Taxonomical nomenclature | |
| Kingdom | Fungi |
| Phylum | Basidiomycota |
| Class | Agaricomycetes |
| Order | Agaricales |
| Family | Marasmiaceae |
| Genus | Rhodocollybia |
| Species | R. maculata |
| Common nomenclature | |
| Common names | Spotted Toughshank |
| Mycological Characteristics | |
| Constituents | |
| Active constituents | Collybolide, various analogs of the former |
Rhodocollybia maculata, common name Spotted Toughshank, is a species of fungus in the mushroom family Marasmiaceae. One of its chemical constituents, collybolide, is a highly potent and selective K-opioid receptor agonist like Salvinorin A. However, unlike salvinorin A it exhibits biased k-opioid agonist activity.
Along with an easily modifiable structure compared with salvinorin A, collybolide is an ideal candidate for the development of novel therapeutics with reduced side effects targeting the K-opioid receptor. It is unknown if collybolide is a hallucinogen in humans.[1] The Rhodocollybia maculata mushroom is considered inedible because of its toughness and bitter flavor.
External links
- Taxonomy and morphology of Rhodocollybia maculata (mushroomexpert.com)
- Rhodocollybia maculata (Wikipedia)
References
- ↑ Gupta, Achla; Gomes, Ivone; Bobeck, Erin N.; Fakira, Amanda K.; Massaro, Nicholas P.; Sharma, Indrajeet; Cavé, Adrien; Hamm, Heidi E.; Parello, Joseph; Devi, Lakshmi A. (2016). "Collybolide is a novel biased agonist of κ-opioid receptors with potent antipruritic activity". Proceedings of the National Academy of Sciences. 113 (21): 6041–6046. doi:10.1073/pnas.1521825113. ISSN 0027-8424. PMC 4889365
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- ↑ Chakraborty, Soumen; Majumdar, Susruta (2020). "Natural Products for the Treatment of Pain: Chemistry and Pharmacology of Salvinorin A, Mitragynine, and Collybolide". Biochemistry. doi:10.1021/acs.biochem.0c00629. ISSN 0006-2960.