Promethazine

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Death may occur when promethazine is combined with other depressants, such as opioids, benzodiazepines, barbiturates, thienodiazepines or other GABAergic substances like alcohol.

Additionally, promethazine is an anticholinergic, and at high doses it may cause delirium and extremely unpleasant if not dangerous experiences. Please be extremely careful when trying this pharmaceutical and use responsible use practices such as always having a tripsitter when using promethazine, especially at high doses.

Promethazine is an anticholinergic, and at high doses it may cause delirium and extremely unpleasant if not dangerous experiences.

Please use responsible use practices such as always having a trip sitter when trying this substance at high dosages.

Death may occur when promethazine is combined with other depressants, such as opioids, benzodiazepines, barbiturates, thienodiazepines or other GABAergic substances like alcohol.

Additionally, promethazine is an anticholinergic, and at high doses it may cause delirium and extremely unpleasant if not dangerous experiences. Please be extremely careful when trying this pharmaceutical and use responsible use practices such as always having a tripsitter when using promethazine, especially at high doses.

Promethazine (commonly sold as Phenergan and also known as an active ingredient in "lean") is a strong muscle relaxant and sedative as well as a weak antipsychotic of the phenothiazine class of medications. It is used primarily for muscle relaxation, preoperative sedation, and nausea. It is also used as an antihistamine, but medications such as diphenhydramine can serve this purpose just as well with the bonus of being over-the-counter and not a strong sedative.

Promethazine's 2D structure. (This image is simply here until the substancebox is made)

History and culture

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Promethazine became especially popular among the Houston rap and hip-hop scene in around 1990, and the trend resurfaced in around 2015 to 16. Often, it was combined with codeine in a preparation called "lean." Lean usually consisted of ice, Sprite or a citrus soda, the promethazine/codeine cough syrup, and sometimes, jolly ranchers added for flavor.

Chemistry

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Pharmacology

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Promethazine is a direct antagonist of histamine H1 receptors, whereas diphenhydramine is an inverse agonist. It is also an antagonist of acetlycholine receptors which is likely the cause of sedation and delirum at higher dosages

Subjective effects

This subjective effects section is a stub. As such, it is still in progress and may contain incomplete or wrong information. You can help by expanding or correcting it.

Toxicity and harm potential

This toxicity and harm potential section is a stub. As a result, it may contain incomplete or even dangerously wrong information! You can help by expanding upon or correcting it. Note: Always conduct independent research and use harm reduction practices if using this substance.

It is strongly recommended that one use harm reduction practices when using this substance.

Dangerous interactions

This dangerous interactions section is a stub. As such, it may contain incomplete or invalid information. You can help by expanding upon or correcting it.

Warning: Many psychoactive substances that are reasonably safe to use on their own can suddenly become dangerous and even life-threatening when combined with certain other substances. The following list provides some known dangerous interactions (although it is not guaranteed to include all of them).

Always conduct independent research (e.g. Google, DuckDuckGo, PubMed) to ensure that a combination of two or more substances is safe to consume. Some of the listed interactions have been sourced from TripSit.

Legal status

This legality section is a stub. As such, it may contain incomplete or wrong information. You can help by expanding it.

See also

• Responsible use