3-FEA

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3-FEA
Chemical Nomenclature
Common names	3-FEA
Substitutive name	3-Fluoroethamphetamine
Systematic name	N-Ethyl-1-(3-fluorophenyl)propan-2-amine
Class Membership
Psychoactive class	Entactogen / Stimulant
Chemical class	Amphetamine
Routes of Administration
WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section. ⇣ Oral Dosage Threshold 15 mg Light 20 - 35 mg Common 35 - 70 mg Strong 70 - 90 mg Heavy 90 mg + Duration Total 4 - 6 hours Onset 20 - 60 minutes Come up 30 - 60 minutes Peak 1.5 - 2.5 hours Offset 2 - 3 hours After effects 6 - 12 hours ⇣ Insufflated Dosage Threshold 15 mg Light 20 - 35 mg Common 35 - 60 mg Strong 50 - 60 mg Heavy 60 mg + Duration Total 1 - 2 hours Onset 5 - 15 minutes Come up 5 - 10 minutes Peak 30 - 60 minutes Offset 30 - 60 minutes After effects 1 - 3 hours DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.
Interactions
Alcohol
GHB
GBL
Opioids
Cannabis
Caffeine
Ketamine
Methoxetamine
Psychedelics
Cocaine
DXM
PCP
25x-NBOMe
2C-T-x
5-MeO-xxT
DOx
Tramadol
aMT
MAOIs

Summary sheet: 3-FEA

3-Fluoroethamphetamine (also known as 3-FEA) is a novel synthetic ring-substituted fluorinated amphetamine compound that produces a combination of entactogenic stimulant effects when administered. 3-FEA is structurally related to a series of designer fluorinated substituted amphetamines that originally included compounds such as 2-FA, 2-FMA, 3-FA, 4-FMA, 4-FA.

Like its parent compound 3-FA, the pharmacological, toxicological, and subjective effects of 3-FEA in humans have yet to be mapped out in detail. Early reports have so far characterized 3-FEA as a moderately potent serotonin and norepinephrine-dominant triple monoamine releaser or reuptake inhibitor that produces a unique balance of entactogenic and stimulant effects that skews more to the hedonic-euphoric side (like one of its popular predecessors 4-FA), than towards the "functional" or "attention enhancing" (e.g. as amphetamine, 2-FA, 2-FMA are considered to be).

3-FEA has an extremely short history of human recreational use and has yet to be documented being sold on the streets. It has recently been made available for sale on the gray market as a research chemical through online vendors.

Due to its potent psychostimulant effects, likely habit-forming properties as well as unknown toxicity profile both in the short and the long term, it is strongly recommended that one use proper harm reduction practices if choosing to experiment with this substance.

Chemistry

Generic structure of an amphetamine molecule

3-Fluoroethamphetamine, or 3-FEA, is a synthetic molecule of the amphetamine chemical class. Molecules of the amphetamine class contain a phenethylamine core comprised of a phenyl ring bound to an amino (NH2) group through an ethyl chain substituted with a methyl group at Rα (i.e. amphetamines are alpha-methylated phenethylamines).

3-FEA is the 3-position fluorinated analog of ethylamphetamine (also known as ethamphetamine). It is also an analog of fenfluramine (which was withdrawn from the market after links between long term use and serotonin-2b receptor-induced heart valve damage was discovered) with the 3-trifluoromethyl group replaced with a 3-fluoro substituent.

Pharmacology

Although 3-FEA has not been formally studied on the same level as traditional amphetamines, it is currently assumed that like other substituted amphetamines with substitutions at similar positions, it most likely acts primarily as a triple reuptake inhibitor and releaser of the monoamine neurotransmitters serotonin, dopamine, and norepinephrine.

Notably, it has been demonstrated that "compared to the unsubstituted ethylamphetamine, 3-fluoroethamphetamine is a weaker releaser of noradrenaline, but a stronger releaser of both dopamine and serotonin, and produced the strongest reinforcing effects in animal studies out of a range of 3-substituted amphetamine derivatives tested, despite not being the most potent dopamine releaser."

This indicates that 3-FEA effectively increases the levels of all the three major monoamine neurotransmitters dopamine, norepinephrine, and serotonin in the brain by binding to and partially blocking the transporter proteins that normally clear those molecules from the synaptic cleft after they have fulfilled their function of conducting a neural impulse. This allows these molecules to accumulate within core regions of the brain to extra-endogenous levels, resulting in a combination of relaxing, stimulating, motivational and physically and cognitively euphoric effects associated with entactogenic substituted amphetamines such as MDMA or other fluorinated amphetamines like 4-FA.

Subjective effects

This subjective effects section is a stub. As such, it is still in progress and may contain incomplete or wrong information. You can help by expanding or correcting it.

Unlike its analogs 2-FA and 2-FMA, both of which have been recognized for being relatively functional and non-recreational stimulants with "dose-ceilings" that can make them harder to abuse, it is likely 3-FEA has more abuse potential and compulsivity due to its similarities in pharmacological properties to the popular entactogenic stimulant euphoriant 4-FA. It is likely a poor candidate for functional use and is likely to be better suited for occasional recreational outings, used very sparingly and cautiously. Disclaimer: The effects listed below cite the Subjective Effect Index (SEI), an open research literature based on anecdotal user reports and the personal analyses of PsychonautWiki contributors. As a result, they should be viewed with a healthy degree of skepticism.

It is also worth noting that these effects will not necessarily occur in a predictable or reliable manner, although higher doses are more liable to induce the full spectrum of effects. Likewise, adverse effects become increasingly likely with higher doses and may include addiction, severe injury, or death ☠.

Physical effects

• Spontaneous tactile sensations - The "body high" of 3-FEA can be described as a moderate to extreme euphoric tingling sensation that can encompass the entire body. It is capable of becoming extremely and hedonic pleasurable at higher dosages. This sensation maintains a consistent presence that steadily rises with the onset and hits its limit once the peak has been reached.
  • Physical euphoria
• Tactile enhancement - This component primarily tends to happen at higher doses only and is rarely observed lower to medium doses.
• Stimulation & Sedation - 3-FEA has been reported to produce a paradoxical combination of stimulating and sedating effects, with the sedating aspects believed to be attributable to the significant amount of serotonin it releases. However, this aspect is not as pronounced as it is with heavier serotonin-dominant releasing agents such MDMA, MDA or MDEA.
  • Perception of increased weight - Depending on whether one is feeling more stimulated than sedated, one will often feel as if they are heavier (as in this case) or lighter in the other.
  • Perception of decreased weight - Depending on whether one is feeling more stimulated than sedated, one will often feel as if they are lighter (as in this case) or heavier in the other.
• Dehydration
• Difficulty urinating - Higher doses of 3-FEA result in an overall difficulty when it comes to urination, an effect that is usually temporary and thought to be harmless.
• Abnormal heartbeat
• Appetite suppression
• Increased heart rate
• Increased perspiration
• Teeth grinding - This component can be considered to be less intense when compared with that of MDMA as well as 2-FMA.
• Vasoconstriction

Cognitive effects

• Anxiety suppression
• Empathy, love, and sociability enhancement
• Disinhibition
• Ego inflation
• Thought acceleration
• Cognitive euphoria
• Focus enhancement
• Motivation enhancement
• Compulsive redosing
• Increased libido
• Increased music appreciation - This component primarily tends to happen at higher doses only, as low to medium doses of 3-FEA are more focused and productivity-oriented.
• Time distortion - This can be described as the experience of time speeding up and passing much quicker than it usually would when sober.
• Wakefulness

After effects

The effects which occur during the offset of a stimulant experience generally feel negative and uncomfortable in comparison to the effects which occurred during its peak. This is often referred to as a "comedown" and occurs because of neurotransmitter depletion. Its effects commonly include:

• Anxiety
• Cognitive fatigue
• Depression
• Irritability
• Motivation suppression
• Thought deceleration
• Wakefulness

Experience reports

Anecdotal reports which describe the effects of this compound within our experience index include:

• Experience:3-FEA - Short Report

Additional experience reports can be found here:

• Erowid Experience Vaults: 3-FEA

Potential dangerous interactions

Warning: Many psychoactive substances that are reasonably safe to use on their own can suddenly become dangerous and even life-threatening when combined with certain other substances. The following list provides some known dangerous interactions (although it is not guaranteed to include all of them).

Always conduct independent research (e.g. Google, DuckDuckGo, PubMed) to ensure that a combination of two or more substances is safe to consume. Some of the listed interactions have been sourced from TripSit.

• "[[DangerousInteraction" contains a listed "[" character as part of the property label and has therefore been classified as invalid.]] - This combination may increase the amount of neurotransmitters such as dopamine to dangerous or even fatal levels. Examples include syrian rue, banisteriopsis caapi, and some antidepressants.
• Stimulants - 3-FEA can be potentially dangerous in combination with other stimulants as it can increase one's heart rate and blood pressure to dangerous levels.
• "[[DangerousInteraction" contains a listed "[" character as part of the property label and has therefore been classified as invalid.]] & "[[DangerousInteraction" contains a listed "[" character as part of the property label and has therefore been classified as invalid.]] - 25x compounds are highly stimulating and physically straining. Combinations with 3-FEA should be strictly avoided due to the risk of excessive stimulation and heart strain. This can result in increased blood pressure, vasoconstriction, panic attacks, thought loops, seizures, and heart failure in extreme cases.
• "[[UncertainInteraction" contains a listed "[" character as part of the property label and has therefore been classified as invalid.]] - Combining alcohol with stimulants can be dangerous due to the risk of accidental over-intoxication. Stimulants mask alcohol's depressant effects, which is what most people use to assess their degree of intoxication. Once the stimulant wears off, the depressant effects will be left unopposed, which can result in blackouts and severe respiratory depression. If mixing, the user should strictly limit themselves to only drinking a certain amount of alcohol per hour.
• "[[UnsafeInteraction" contains a listed "[" character as part of the property label and has therefore been classified as invalid.]] - Combinations with DXM should be avoided due to its inhibiting effects on serotonin and norepinephrine reuptake. There is an increased risk of panic attacks and hypertensive crisis, or serotonin syndrome with serotonin releasers (MDMA, methylone, mephedrone, etc.). Monitor blood pressure carefully and avoid strenuous physical activity.
• "[[UnsafeInteraction" contains a listed "[" character as part of the property label and has therefore been classified as invalid.]] - Any neurotoxic effects of MDMA are likely to be increased when other stimulants are present. There is also a risk of excessive blood pressure and heart strain (cardiotoxicity).
• "[[UncertainInteraction" contains a listed "[" character as part of the property label and has therefore been classified as invalid.]] - Some reports suggest combinations with MXE may dangerously increase blood pressure and increase the risk of mania and psychosis.
• "[[UncertainInteraction" contains a listed "[" character as part of the property label and has therefore been classified as invalid.]] - Both classes carry a risk of delusions, mania and psychosis, and these risk may be multiplied when combined.
• "[[UnsafeInteraction" contains a listed "[" character as part of the property label and has therefore been classified as invalid.]] - 3-FEA may be dangerous to combine with other stimulants like cocaine as they can increase one's heart rate and blood pressure to dangerous levels.
• "[[DangerousInteraction" contains a listed "[" character as part of the property label and has therefore been classified as invalid.]] - Tramadol is known to lower the seizure threshold and combinations with stimulants may further increase this risk.
• MDMA - The neurotoxic effects of MDMA may be increased when combined with amphetamines.
• Cocaine - This combination may increase strain on the heart to dangerous levels.

Toxicity and harm potential

Further information: Research chemicals § Toxicity and harm potential

The toxicity and long-term health effects of recreational 3-FEA use do not seem to have been studied in any scientific context and the exact toxic dosage is unknown. This is likely because 3-FEA has an extremely brief history of human usage, first becoming available in mid-2016. Early anecdotal reports from people within the community who have tried 3-FEA suggest that there do not seem to be any negative health effects attributed to simply trying this substance at low to moderate doses by itself and using it sparingly (although nothing can be completely guaranteed).

Likely due to its properties as a serotonin-releasing entactogen, it is possible 3-FEA may display unusually high affinity and activity at the 5-HT_2B receptor, which like 5-HT_2B agonists such as MDMA and fenfluramine would make it would be cardiotoxic with long-term or heavy use.

It is strongly recommended that one use proper harm reduction practices when using this substance.

Tolerance and addiction potential

Although it still remains to be seen, the chronic use of 3-FEA will likely become considered to be moderately addictive with a high potential for abuse and capable of causing psychological dependence among a certain population of users. When dependence or addiction has developed, cravings and withdrawal effects may occur if a person suddenly stops their usage.

Tolerance to many of the effects of 3-FEA develops with prolonged and repeated use. This results in users having to administer increasingly large doses to achieve the same effects. Afterward, it takes about 3 - 5 days for the tolerance to be reduced to half and 10 days to be back at baseline (in the absence of further consumption). 3-FEA presents cross-tolerance with [[Cross-tolerance::all dopaminergic and serotonergic stimulants]] and entactogens, meaning that after the consumption of 3-FEA all stimulants will have a reduced effect (including atypical stimulants one might not expect, like MDMA or amphetamine due to its reliance on dopamine and norepinephrine stores to exert the full spectrum of its effect).

Psychosis

Main article: Stimulant psychosis

Abuse of compounds within the amphetamine chemical class at high dosages for prolonged periods of time can potentially result in a stimulant psychosis that may present with a variety of symptoms (e.g., paranoia, hallucinations, or delusions). A review on treatment for amphetamine, dextroamphetamine, and methamphetamine abuse-induced psychosis states that about 5–15% of users fail to recover completely. The same review asserts that, based upon at least one trial, antipsychotic medications effectively resolve the symptoms of acute amphetamine psychosis. Psychosis very rarely arises from therapeutic use.

Legality

This legality section is a stub. As such, it may contain incomplete or wrong information. You can help by expanding it.

3-FEA is currently a grey area compound within all parts of the world, meaning its regulation lies in a legal grey area and that it is not known to be specifically illegal ("scheduled") within any country. However, people may still be charged for its possession under certain circumstances such as under analogue laws and with intent to sell or consume.

• United States: 3-FEA may be considered to be an analog of amphetamine, thus falling under the Federal Analog Act. The Federal Analog Act, 21 U.S.C. § 813, is a section of the United States Controlled Substances Act, allowing any chemical "substantially similar" to an illegal drug (in Schedule I or II) to be treated as if it were also in Schedule I or II, but only if it is intended for human consumption.
• United Kingdom: 3-FEA is considered a Class A drug as a result of the amphetamine analogue clause of the Misuse of Drugs Act 1971.
• Canada: 3-FEA would be considered Schedule I as it is an analogue of Amphetamine.
• New Zealand: 3-FEA is an amphetamine analogue, so is a Schedule 3 controlled substance in New Zealand.

See also

• Responsible use
• Designer drug
• Entactogen
• Stimulants
• Substituted amphetamines
• MDEA
• 4-FA
• 3-FA
• 3-FMA

External links

• 3-FEA (Wikipedia)