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4-AcO-MiPT

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Revision as of 22:01, 17 April 2017 by >BronzeManul (Corrected legal status in UK to being Class A in Misuse of Drugs Act 1971 and thus not covered by the Psychoactive Substances Act 2016. Added USA legal status.)
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4-AcO-MiPT
Chemical Nomenclature
Common names 4-AcO-MiPT, Mipracetin, O-Acetylmiprocin
Substitutive name 4-Acetoxy-N-isopropyl-N-methyltryptamine
Systematic name [3-[2-[Isopropyl(methyl)amino]ethyl]-1H-indol-4-yl] acetate
Class Membership
Psychoactive class Psychedelic
Chemical class Tryptamine
Routes of Administration

WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section.



⇣ Oral
Dosage
Threshold 5 mg
Light 10 - 15 mg
Common 15 - 20 mg
Strong 20 - 35 mg
Heavy 35 mg +
Duration
Total 4 - 8 hours
Onset 20 - 60 minutes
Come up 1 - 2 hours
Peak 1.5 - 3 hours
Offset 1 - 2 hours
After effects 2 - 4 hours









DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.

Interactions
Summary sheet: 4-AcO-MiPT

4-Acetoxy-N-methyl-N-isopropyltryptamine (abbreviated 4-AcO-MiPT and also known as mipracetin) is a synthetic psychedelic tryptamine. It is the acetylated form of 4-HO-MiPT (also known as miprocin) and is a higher homolog of 4-AcO-DMT, 4-AcO-MET and 4-AcO-DET. These substances are commonly hypothesized to act primarily as prodrugs for their respective hydroxylated counterparts (e.g. 4-HO-DMT, 4-HO-MET and 4-HO-DET), although there is on-going debate as to whether they possess their own innate activity.[citation needed]

There is very little information on the human pharmacology or toxicity of 4-AcO-MiPT, although analytical methods have been developed for its detection.[1][2] Today it is either used recreationally or as an entheogenic substance and is typically acquired through the use of online research chemical vendors. It remains relatively uncommon and has very little history of human usage.

Chemistry

4-AcO-MiPT, or 4-Acetoxy-N-isopropyl-N-methyltryptamine, is a synthetic indole alkaloid molecule of the tryptamine class. Tryptamines share a core structure comprised of a bicylic indole heterocycle attached at R3 to an amino group via an ethyl side chain. 4-AcO-MiPT is substituted at R4 of its indole heterocycle with an acetoxy (AcO) functional group CH3COO−. It also contains isopropyl and methyl chains bound to the terminal amine RN of its tryptamine backbone (MiPT).

4-AcO-MiPT is the N-substituted methisopropyl homologue of 4-HO-DMT (psilocin). 4-AcO-MiPT is the acetate ester analog of MiPT and the N-substituted methisopropyl analog of 4-AcO-DMT.[3]

Pharmacology

Further information: Serotonergic psychedelic

Like with most psychedelic tryptamines, 4-AcO-MiPT is thought to act principally as a 5-HT2A partial agonist. The psychedelic effects are believed to come from 4-AcO-MiPT's binding efficacy at the 5-HT2A receptors.

However, the role of these interactions and how they result in the psychedelic experience continues to remain elusive.

Subjective effects

Disclaimer: The effects listed below cite the Subjective Effect Index (SEI), an open research literature based on anecdotal user reports and the personal analyses of PsychonautWiki contributors. As a result, they should be viewed with a healthy degree of skepticism.

It is also worth noting that these effects will not necessarily occur in a predictable or reliable manner, although higher doses are more liable to induce the full spectrum of effects. Likewise, adverse effects become increasingly likely with higher doses and may include addiction, severe injury, or death ☠.

Physical effects

  • Excessive yawning
  • Sedation - In terms of its effects on the physical energy levels of the tripper, 4-AcO-MiPT is considered by most to be relaxing, stoning and mildly sedating. This sense of sedation is often accompanied by uncontrollable yawning.
  • Spontaneous tactile sensations - The "body high" of 4-AcO-MiPT can be described as a pleasurable, warm, soft and all-encompassing tingling sensation. This maintains a consistent presence that steadily rises with the onset and hits its limit once the peak has been reached.
  • Pupil dilation
  • Runny nose
  • Watery eyes

Cognitive effects

Much like its hydroxylated counterpart 4-HO-MiPT, the cognitive effects of 4-AcO-MiPT are described by many as extremely relaxing, complex and stoning in style when compared to other commonly used psychedelics such as LSD or 2C-B which tend to be energetic and stimulating. It contains a notable number of typical and unique psychedelic cognitive effects.

The most prominent of these typical effects generally include:

Visual effects

Enhancements

Distortions

Geometry

The visual geometry that is present throughout this trip can be described as more similar in appearance to that of 4-AcO-DMT, ayahuasca and 2C-T-7 than LSD or 2C-B. It can be comprehensively described through its variations as intricate in complexity, abstract in form, organic in style, structured in organization, brightly lit and multicoloured in scheme, glossy in shading, soft in edges, large in size, slow in speed, smooth in motion, rounded in corners, non-immersive in depth and consistent in intensity. The visuals have a very "natural" feel to them and at higher dosages are significantly more likely to result in states of level 8B visual geometry over level 8A.

Hallucinatory states

4-AcO-MiPT and its various other forms can produce a full range of high level hallucinatory states in a fashion that is more consistent and reproducible than that of many other commonly used psychedelics. These effects generally include:

Auditory effects

Experience reports

There are currently no anecdotal reports which describe the effects of this compound within our experience index. Additional experience reports can be found here:

Toxicity and harm potential

Further information: Research chemicals § Toxicity and harm potential, and Responsible use § Hallucinogens

The toxicity and long-term health effects of recreational 4-AcO-MiPT use do not seem to have been studied in any scientific context and the exact toxic dose is unknown. This is because 4-AcO-MiPT is a research chemical with very little history of human usage. Anecdotal evidence from people within the psychonaut community who have tried 4-AcO-MiPT suggests that there are no negative health effects attributed to simply trying the drug by itself at low to moderate doses and using it very sparingly (but nothing can be completely guaranteed). Independent research should always be done to ensure that a combination of two or more substances is safe before consumption.

It is strongly recommended that one use harm reduction practices when using this drug.

Tolerance and addiction potential

4-AcO-MiPT is not habit-forming and the desire to use it can actually decrease with regular consumption. Like with most psychedelics, it is most often thought to be self-regulating.

Tolerance to the effects of 4-AcO-MiPT are built almost immediately after ingestion. After that, it takes about 3 days for the tolerance to be reduced to half and 7 days to be back at baseline (in the absence of further consumption). 4-AcO-MiPT presents cross-tolerance with [[Cross-tolerance::all psychedelics]], meaning that after the consumption of 4-AcO-MiPT all psychedelics will have a reduced effect.

This legality section is a stub.

As such, it may contain incomplete or wrong information. You can help by expanding it.

Due to its relative obscurity, the possession and sale of 4-AcO-MiPT is unscheduled in most countries.

  • United Kingdom: 4-AcO-MiPT is a Class A drug in the UK as it is an ester of the drug 4-HO-MiPT.[4], which is a Class A drug as a result of the tryptamine catch-all clause.[5]
  • United States: 4-AcO-MiPT is unscheduled in the United States. It may be considered an analogue of psilocin (4-HO-DMT) which is a Schedule I drug under the Controlled Substances Act. As such, the sale for human consumption or the use for illicit non-medical or industrial intents and purposes could be prosecuted as crimes under the Federal Analogue Act.[citation needed]
  • Sweden: 4-AcO-MiPT is classified as "health hazard" under the act "Lagen om förbud mot vissa hälsofarliga varor" (translated to the "Act on the Prohibition of Certain Goods Dangerous to Health"). The drug is listed in their regulation SFS 2005:733, making it illegal to sell or possess.[6]

See also

References

  1. ↑ http://www.sciencedirect.com/science/article/pii/S0039914008005808
  2. ↑ http://link.springer.com/article/10.1007%2Fs00044-011-9794-y
  3. ↑ 4-Acetoxy-MiPT - PubChem | https://pubchem.ncbi.nlm.nih.gov/compound/467835878
  4. ↑ Misuse of Drugs Act 1971 (Legislation.gov.uk) | http://www.legislation.gov.uk/ukpga/1971/38/schedule/2/part/I/paragraph/3
  5. ↑ Misuse of Drugs Act 1971 (Legislation.gov.uk) |http://www.legislation.gov.uk/ukpga/1971/38/schedule/2/part/I#reference-M_F_c7632653-ddad-4420-f307-e3da1e36d30e
  6. ↑ http://www.notisum.se/rnp/sls/sfs/20050733.pdf


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