25x-NBOMe
Members of the NBOMe series have been linked to numerous overdoses and fatalities.[1][2][3]
It is strongly discouraged to insufflate (snort) or take higher doses of these compounds. Please see this section for more details.
25x-NBOMe is the general form of the NBOMe series of psychedelic phenethylamines. The series had nearly no history of human use before 2010 when some of the first compounds became available for purchase from online research chemical vendors.
It is often sold as LSD, but one fundamental difference between 25x-NBOMe and LSD is that NBOMe is only active when taken through a sublingual or insufflated route. This means that to get the full effects, 25x-NBOMe blotter paper must be lightly chewed on for 20+ minutes and never immediately swallowed. 25x-NBOMe blotters cause numbness of the tongue and have a distinct taste that has been described as "strongly bitter", "metallic", or "chemical like" by those who have tried them. This is unlike LSD blotters, which will not cause numbness of the tongue and may be tasteless or have a slight flavour depending on the amount of ink on the blotter and the composition of the blotter paper. Although these differences can be helpful in identifying an unwanted compound on a blotter, it is recommended that more reliable methods of identification be used, such as the use of testing reagents like the Ehrlich reagent. Insufflation, however, is not recommended; reports of people suffering dangerous and often fatal overdoses due to this route of administration have been surfacing.
Chemistry
In a comparison of 25x-NBOMe and 2C-x chemicals, each 25x-NBOMe molecule is a serotonergic N-benzyl derivative of the corresponding 2C-x molecule. This change in structure results in an increase in potency. It differs from the related 2C-x structurally through a substitution on the amine (NH2) with a 2-methoxybenzyl (BOMe) group. The addition of this BOMe group also causes most of the compounds to have relatively the same duration, regardless of how long the 2C-x counterpart lasts.
List of 25x-NBOMe compounds
| Compound | R4 | Structure |
|---|---|---|
| 25B-NBOMe | Br | 
|
| 25C-NBOMe | Cl | 
|
| 25D-NBOMe | CH3 | 
|
| 25I-NBOMe | I | 
|
| 25N-NBOMe | NO2 | 
|
Health effects, potential addiction and tolerance
The 25x-NBOMe chemicals, as with many other serotonergic psychedelics, should not be taken in combination with SSRIs (selective serotonin reuptake inhibitors) or tricyclic antidepressants. This helps to avoid serotonin syndrome, a potentially life-threatening condition in which an abundance of serotonin builds up in the body, which in some cases can be fatal.
Legal issues
- USA: In the US, some of the 25x-NBOMe chemicals are listed as Schedule I substances and others may be considered analogues under the Federal Analogue Act.[citation needed]