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PRO-LAD

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PRO-LAD
Chemical Nomenclature
Common names PRO-LAD
Substitutive name 6-Propyl-6-nor-lysergic acid diethylamide
Systematic name (8β)-N,N-Diethyl-6-propyl-9,10-didehydroergoline-8-carboxamide
Class Membership
Psychoactive class Psychedelic
Chemical class Lysergamide
Routes of Administration

WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section.



⇣ Oral
Dosage
Threshold 20 µg
Light 50 - 100 µg
Common 100 - 200 µg
Strong 200 - 350 µg
Heavy 350 µg +
Duration
Total 6 - 8 hours
Onset 30 - 45 minutes









DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.

Interactions
Summary sheet: PRO-LAD

PRO-LAD (or 6-propyl-6-nor-lysergic acid diethylamide) is a psychedelic hallucinogenic drug of the lysergamide family.

This substance has little to no history of human usage. It was first investigated by Andrew J. Hoffman and David E. Nichols in 1984 as part of a series of LSD analogues, also including AL-LAD and ETH-LAD. [1]. It was later described as an analog of LSD by Alexander Shulgin in the book TiHKAL.[2] It is around as potent as LSD itself with an active dose reported at between 100 and 200 micrograms.[3]

Chemistry

PRO-LAD, or 6-propyl-6-nor-lysergic acid diethylamide, is a semi-synthethic alkaloid of the lysergamide famiy. PRO-LAD is a structural analogue of lysergic acid with an N,N-diethylamide functional group bound to RN of the chemical structure. This core polycyclic structure is an ergoline derivative and has tryptamine and phenethylamine groups embedded within it. The structure of PRO-LAD contains a bicyclic hexahydroindole fused to a bicyclic quinoline group (nor-lysergic acid).

PRO-LAD does not contain a methyl group substituted at R6 of its nor-lysgeric acid skeleton; this is represented by the nor- prefix. Instead, PRO-LAD is substituted at R6 with a propyl group. At R8 of the structure, a N,N-diethyl carboxamide is bound. PRO-LAD is a chiral compound with two stereocenters at R5 and R8. PRO-LAD, also called (+)-D-PRO-LAD, has an absolute configuration of (5R, 8R). PRO-LAD is a derivative of LSD, differing by the addition of two carbons to the methyl group at R6 of the structure to form a propyl chain. PRO-LAD is also homologous to ETH-LAD, which contains an ethyl substitution at R6 instead of a propyl chain.

Pharmacology

Main article: Serotonergic psychedelic

PRO-LAD likely acts as a 5-HT2A partial agonist. The psychedelic effects are believed to come from PRO-LAD's efficacy at the 5-HT2A receptors. However, the role of these interactions and how they result in the psychedelic experience continues to remain elusive.

Subjective effects

 This subjective effects section is a stub.

As such, it is still in progress and may contain incomplete or wrong information.

You can help by expanding or correcting it.

Disclaimer: The effects listed below cite the Subjective Effect Index (SEI), an open research literature based on anecdotal user reports and the personal analyses of PsychonautWiki contributors. As a result, they should be viewed with a healthy degree of skepticism.

It is also worth noting that these effects will not necessarily occur in a predictable or reliable manner, although higher doses are more liable to induce the full spectrum of effects. Likewise, adverse effects become increasingly likely with higher doses and may include addiction, severe injury, or death ☠.

Physical effects

Cognitive effects

Visual effects

Enhancements

Distortions

Geometry

Hallucinatory states

Auditory effects

Toxicity and harm potential

Main articles: Research chemicals § Toxicity and harm potential & Responsible use § Hallucinogens

The toxicity and long-term health effects of recreational PRO-LAD do not seem to have been studied in any scientific context and the exact toxic dose is unknown. This is because PRO-LAD is a research chemical with very little history of human usage. Anecdotal evidence from people within the psychonaut community who have tried PRO-LAD suggests that there are no negative health effects attributed to simply trying the drug by itself at low to moderate doses and using it very sparingly (but nothing can be completely guaranteed). Independent research should always be done to ensure that a combination of two or more substances is safe before consumption.

It is strongly recommended that one use harm reduction practices when using this drug.

Tolerance and addiction potential

PRO-LAD is not habit-forming and the desire to use it can actually decrease with use. It is most often self-regulating.

Tolerance to the effects of PRO-LAD are built almost immediately after ingestion. After that, it takes about 3 days for the tolerance to be reduced to half and 7 days to be back at baseline (in the absence of further consumption). PRO-LAD presents cross-tolerance with [[Cross-tolerance::all psychedelics]], meaning that after the consumption of PRO-LAD all psychedelics will have a reduced effect.

This legality section is a stub.

As such, it may contain incomplete or wrong information. You can help by expanding it.

  • UK: On June 10, 2014, the UK Advisory Council on the Misuse of Drugs (ACMD) recommended that PRO-LAD be specifically named in the UK Misuse of Drugs Act as a class A drug despite not identifying it as ever having been sold or any harm associated with its use.[4] The UK Home office accepted this advice and announced a ban of the substance to be enacted on 6 January 2015 as part of the Misuse of Drugs Act 1971 (Amendment) (No. 2) Order 2014.
  • Switzerland: On December 1, 2015, Switzerland added PRO-LAD to the list of controlled substances.[5]
  • Latvia - PRO-LAD is illegal in Latvia. Although it isn't officially scheduled, it is controlled as an LSD structural analog due to an amendment made on June 1th, 2015.[6]

See also

References

  1. ↑ https://www.ncbi.nlm.nih.gov/pubmed/4032428 | Hoffman AJ, Nichols DE. Synthesis and LSD-like discriminative stimulus properties in a series of N(6)-alkyl norlysergic acid N,N-diethylamide derivatives. J Med Chem. 1985 Sep;28(9):1252-5. PubMed PMID: 4032428
  2. ↑ PRO-LAD (TiHKAL / IsomerDesign | https://isomerdesign.com/PiHKAL/read.php?domain=tk&id=51
  3. ↑ Synthesis and LSD-like discriminative stimulus properties in a series of N(6)-alkyl norlysergic acid N,N-diethylamide derivatives (PubMed.gov / NCBI) | https://www.ncbi.nlm.nih.gov/pubmed/4032428
  4. ↑ ACMD (10 June 2014). "Update of the Generic Definition for Tryptamines" | https://www.gov.uk/government/uploads/system/uploads/attachment_data/file/318693/UpdateGenericDefinitionTryptamines.pdf
  5. ↑ https://www.admin.ch/opc/de/official-compilation/2015/5093.pdf
  6. ↑ Noteikumi par Latvijā kontrolējamajām narkotiskajām vielām, psihotropajām vielām un prekursoriem (2.4.punkts) | http://likumi.lv/doc.php?id=121086
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