DOM

DOM
Chemical Nomenclature
Common names	DOM, STP (Serenity, Tranquility, and Peace)
Substitutive name	2,5-Dimethoxy-4-methylamphetamine
Systematic name	1-(2,5-Dimethoxy-4-methylphenyl)-2-aminopropane
Class Membership
Psychoactive class	Psychedelic
Chemical class	Amphetamine
Routes of Administration
WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section. ⇣ Oral Dosage Threshold 0.5 mg Light 1 - 3 mg Common 3 - 5 mg Strong 5 - 10 mg Heavy 10 mg + Duration Total 12 - 16 hours Onset 1 - 2 hours Come up 2 - 3 hours Peak 6 - 8 hours Offset 3 - 5 hours After effects 4 - 16 hours DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.
Interactions
Lithium

Summary sheet: DOM

2,5-Dimethoxy-4-methylamphetamine, also known as DOM and STP ("serenity, tranquility and peace"), is a psychedelic drug of the substituted phenethylamine and amphetamine chemical classes. It is a member of the DOx family of compounds.

DOM was first synthesized and tested in 1963 by Alexander Shulgin who was investigating the effect of 4-position substitutions on psychedelic amphetamines. It has a very limited history of human usage prior to the 1991 publication of its synthesis and pharmacology in PiHKAL (Phenethylamines i Have Known And Loved) by Alexander Shulgin. This particular substance is part of the so-called "magical half-dozen" which refers to Shulgin's self-rated most important phenethylamine compounds, all of which except mescaline he developed and synthesized himself. They are found within the first book of PiHKAL, and are as follows: Mescaline, DOM, 2C-B, 2C-E, 2C-T-2 and 2C-T-7. In modern times, it is used as a recreational drug and an entheogen.

DOM is a highly dose sensitive psychedelic that is often sold on blotting paper and known for its strong visuals and intense body load. Many reports also indicate that the effects of this chemical may be overly intense for those who are not already experienced with psychedelics.

Chemistry

DOM or 4-methyl-2,5-dimethoxy-amphetamine is a molecule of the amphetamine class. Amphetamines are substituted phenethylamines containing a phenyl ring bound to an amino (NH₂) group through an ethyl chain and a methyl group bound to the alpha carbon R_α. DOM contains methoxy functional groups CH₃O- attached to carbons R₂ and R₅ and a methyl group attached to carbon R₄ of the phenyl ring. DOM is the amphetamine analogue of the phenethylamine 2C-D.

Pharmacology

Main article: Serotonergic psychedelic

DOM is a selective 5-HT_2A, 5-HT_2B, and 5-HT_2C receptor partial agonist. Its psychedelic effects are mediated by its agonistic properties at the 5-HT_2A receptor. Due to its selectivity, DOM is often used in scientific research when studying the 5-HT₂ receptor subfamily.

DOM is a chiral molecule, and R-(-)-DOM is the more active enantiomer, functioning as a potent agonist of the serotonin 5-HT family of receptors (mainly of the 5-HT2 subtype).

However, the role of these interactions and how they result in the psychedelic experience continues to remain elusive.

Subjective effects

Disclaimer: The effects listed below cite the Subjective Effect Index (SEI), an open research literature based on anecdotal user reports and the personal analyses of PsychonautWiki contributors. As a result, they should be viewed with a healthy degree of skepticism.

It is also worth noting that these effects will not necessarily occur in a predictable or reliable manner, although higher doses are more liable to induce the full spectrum of effects. Likewise, adverse effects become increasingly likely with higher doses and may include addiction, severe injury, or death ☠.

Physical effects

• Spontaneous tactile sensations - The "body high" of DOM is manifested as somewhat intense in comparison to most classical psychedelics. However, in comparison to DOC and the overwhelming forcefulness of 2C-E, it can actually be considered quite mild. The sensation itself can be described as a constantly present yet somewhat mild energetic pins and needles sensation that encompasses a person’s entire body. This is coupled with a euphoric, fast-moving, sharp and location specific tingling sensation. It is usually felt over every square inch of the skin, but occasionally manifests itself in the form of a continuously shifting tingling sensation that travels up and down the body in spontaneous waves.
• Stimulation - In terms of its effects on the physical energy levels of the tripper, DOM is usually considered to be mildly stimulating at levels which do not become overwhelming, encouraging trippers to move around, run, dance, climb and generally engage in physical activities. In comparison, other more commonly used psychedelics such as psilocin are generally sedating and relaxed.
• Tactile enhancement - Feelings of enhanced tactile sensation are consistently present at moderate levels throughout most DOM trips. Once Level 8A visuals are reached, an intense sensation of suddenly becoming aware of and being able to feel every single nerve ending across a person's entire body all at once is consistently present.
• Nausea - Mild to extreme nausea are reported when consumed in moderate to high dosages and either passes once the tripper has vomited or gradually fades by itself as the peak sets in.
• Vasoconstriction - This effect is usually only present at higher dosages, but can be particularly uncomfortable.
• Bodily control enhancement
• Increased heart rate
• Increased blood pressure
• Pupil dilation

Cognitive effects

The cognitive effects of DOM are described by many as a combination of extreme mental stimulation and a powerful enhancement of a person's current mental state.

The total sum of these cognitive components regardless of the setting generally includes:

• Empathy, love, and sociability enhancement - This component is consistently manifested only in the context of social settings in which one is within the company of others. These feelings of sociability, love and empathy are a little weaker and less sharp than those found on substances such as MDMA and 2C-B, but still prove strong enough to provide long-lasting therapeutic effects.
• Analysis enhancement
• Conceptual thinking
• Emotion enhancement
• Immersion enhancement
• Increased libido
• Increased music appreciation
• Memory suppression
  • Ego death
• Novelty enhancement
• Personal bias suppression
• Thought acceleration
• Thought connectivity
• Time distortion
• Wakefulness

Visual effects

Enhancements

• Acuity enhancement
• Colour enhancement
• Pattern recognition enhancement

Distortions

• Drifting (melting, flowing, breathing and morphing) - In comparison to other psychedelics, this effect can be described as highly detailed, slow and smooth in motion, static in appearance and unrealistic/cartoon-like in style.
• Tracers
• After images
• Symmetrical texture repetition
• Colour shifting
• Scenery slicing

Geometry

The visual geometry that is present throughout this trip can be described as more similar in appearance to that of 4-AcO-DMT or ayahuasca than that of LSD, 2C-B or 2C-I. It can be comprehensively described through its variations as intricate in style, equally algorithmic and abstract in form, equally synthetic and organic in style, structured in organization, brightly lit in lighting, multicoloured in scheme, glossy in shading, sharp in edges, large in size, fast in speed, smooth in motion, equal in rounded and angular corners, non-immersive in depth and consistent in intensity. Higher dosages are significantly more likely to result in states of level 8A visual geometry over level 8B.

Hallucinatory states

DOM produces a full range of high level hallucinatory states in a fashion that is more consistent and reproducible than that of many other commonly used psychedelics. This holds particularly true in comparison to other substances within the phenethylamine family. These effects include:

• Transformations
• Internal hallucinations (autonomous entities; settings, sceneries, and landscapes; alterations in perspective and scenarios and plots) - In comparison to other psychedelics such as LSD, DOM is extremely high in its internal hallucinations. This particular effect commonly contains hallucinations with scenarios, settings, concepts and autonomous entity contact. They can be comprehensively described in terms of their variations as lucid in believability, interactive in style, new experiences in content, autonomous in controllability and geometry-based in appearance. They are more common within dark environments and can be described as internal in their manifestation, lucid in believability, interactive in style and almost exclusively of a personal, religious, spiritual, science-fiction, fantasy, surreal, nonsensical or transcendental nature in their overall theme.

Auditory effects

• Enhancements
• Distortions
• Hallucinations

Experience reports

There are currently no anecdotal reports which describe the effects of this compound within our experience index. Additional experience reports can be found here:

• Erowid Experience Vaults: DOM

Toxicity and harm potential

Main articles: Research chemicals § Toxicity and harm potential & Responsible use § Hallucinogens

The toxicity and long-term health effects of recreational DOM use do not seem to have been studied in any scientific context and the exact toxic dose is unknown. This is because DOM is a research chemical with very little history of human usage. Anecdotal evidence from people within the psychonaut community who have tried DOM suggests that there are no negative health effects attributed to simply trying the drug by itself at low to moderate doses and using it very sparingly (but nothing can be completely guaranteed). Independent research should always be done to ensure that a combination of two or more substances is safe before consumption.

It is strongly recommended that one use harm reduction practices when using this drug.

Tolerance and addiction potential

DOM is not habit-forming and the desire to use it can actually decrease with use. It is most often self-regulating.

Tolerance to the effects of DOM are built almost immediately after ingestion. After that, it takes about 3 days for the tolerance to be reduced to half and 7 days to be back at baseline (in the absence of further consumption). DOM presents cross-tolerance with [[Cross-tolerance::all psychedelics]], meaning that after the consumption of DOM all psychedelics will have a reduced effect.

Legal issues

• U.K.: DOM is a Class A drug.
• U.S.: DOM is a Schedule I drug.
• Canada: DOM is a Schedule I drug.
• New Zealand: DOM is a Class C drug.
• Belgium: DOM is a Schedule I drug.
• Latvia: DOM is a Schedule I controlled substance.
• Switzerland: Possession, production and sale is illegal.

See also

• Responsible use
• Psychedelics
• Phenethylamines
• Alexander Shulgin
• DOx
• DOC
• DOB
• 2C-D

External links

• DOM (Wikipedia)
• DOM (Erowid)
• DOM (Bluelight)
• DOM (TripSit)
• DOM experiences (Erowid)
• DOM (The Drug Classroom)