2C-H

2C-H
Chemical Nomenclature
Common names	2C-H, DMPEA
Substitutive name	2,5-Dimethoxyphenethylamine
Systematic name	2-(2,5-Dimethoxyphenyl)ethanamine
Class Membership
Psychoactive class	Stimulant / Psychedelic
Chemical class	Phenethylamine
Routes of Administration
WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section. ⇣ Oral Dosage Common Unknown Duration Total Unknowm DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.
Interactions

Summary sheet: 2C-H

2C-H (2,5-Dimethoxyphenethylamine) is a lesser-known substituted phenethylamine that is the traditional precursor to 2C-B, 2C-C and 2C-I. It was first synthesized in 1932 by Johannes S. Buck and was later studied in the 1970s by Alexander Shulgin, who published his findings in his book PiHKAL.

Shulgin lists both the dosage and duration as unknown, as 2C-H is likely easily broken down by the MAO enzyme in the liver and is thus considered probably inactive. However, there are some anecdotal reports online suggesting that it may be active when taken sublingually. When combined with an MAOI, it may be orally active.

Chemistry

2C-H, or 2,5-dimethoxyphenethylamine, is a substituted phenethylamine featuring a phenyl ring bound to an amino (NH₂) group through an ethyl chain. 2C-H contains methoxy functional groups CH₃O- attached to carbons R₂ and R₅ as well as a hydrogen atom attached to carbon R₄ of the phenyl ring. 2C-H belongs to the 2C family of phenethylamines which contain methoxy groups on the 2 and 5 positions of the benzene ring, and is also their simplest member. It is commonly used as a precursor to other compounds of the 2C family, including 2C-B, 2C-C, 2C-I, and 2C-N.

Pharmacology

There is no record of 2C-H trials in humans, as it would likely be destroyed by monoamine oxidase enzymes before causing any significant psychoactive effects. Very little data exists about the pharmacological properties, metabolism, and toxicity of 2C-H. However, it has been shown to have binding affinity towards 5-HT2C and 5-HT2A receptors in rats.

Subjective effects

This subjective effects section is a stub. As such, it is still in progress and may contain incomplete or wrong information. You can help by expanding or correcting it.

Experience reports

There are currently no anecdotal reports which describe the effects of this compound within our experience index. Additional experience reports can be found here:

• Erowid Experience Vaults: 2C-H

Toxicity and harm potential

Main articles: Research chemicals § Toxicity and harm potential & Responsible use § Hallucinogens

The toxicity and long-term health effects of recreational 2C-H use do not seem to have been studied in any scientific context and the exact toxic dose is unknown. This is because 2C-H is a research chemical with very little history of human usage. Independent research should always be done to ensure that a combination of two or more substances is safe before consumption.

It is strongly recommended that one use harm reduction practices when using this drug.

Legal issues

• Canada: As of October 31st, 2016, 2C-H is a controlled substance (Schedule III) in Canada, and is thus illegal to possess, produce and sell.
• United States: As of July 9, 2012, 2C-H is a Schedule I controlled substance in the United States, under the Synthetic Drug Abuse Prevention Act of 2012.
• United Kingdom: It is illegal to produce, supply, or import this drug under the Psychoactive Substance Act, which came into effect on May 26th, 2016.

See also

• Responsible use
• Substituted phenethylamine
• Stimulant
• 2C-B

External links

• 2C-H (Wikipedia)
• 2C-H (PiHKAL/Erowid)
• 2C-H (Bluelight)
• 2C-H via 2,5-Dimethoxymandelonitrile (Rhodium/Erowid)