3-MMC

3-MMC
Chemical Nomenclature
Common names	3-MMC, Metaphedrone
Substitutive name	3-Methylmethcathinone
Systematic name	(RS)-2-​(Methylamino)-​1-​(3-​methylphenyl)-​1-​propanone
Class Membership
Psychoactive class	Stimulant / Entactogen
Chemical class	Cathinone
Routes of Administration
WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section. ⇣ Oral Dosage Threshold 25 mg Light 50 - 150 mg Common 150 - 250 mg Strong 250 - 350 mg Heavy 350 mg + Duration Total 4 - 6 hours Onset 10 - 30 minutes Come up 30 - 60 minutes Peak 2 - 3 hours Offset 1 - 1.5 hours After effects 2 - 4 hours ⇣ Insufflated Dosage Threshold 10 mg Light 20 - 40 mg Common 40 - 60 mg Strong 60 - 120 mg Heavy 120 mg + Duration Total 2.5 - 4.5 hours Onset 5 - 10 minutes Come up 10 - 20 minutes Peak 1 - 1.5 hours Offset 1 - 2 hours After effects 1 - 1.5 hours ⇣ Intravenous Dosage Bioavailability ~100% Threshold < 10 mg Light 10 - 25 mg Common 25 - 50 mg Strong 50 - 100 mg Heavy 100 mg+ Duration Total 2.0 - 4.0 hours Onset 15 - 30 seconds Come up 1 - 2 minutes Peak 1 - 1.5 hours Offset 1 - 2 hours After effects 1 - 2 hours DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.
Interactions
MAOIs
Serotonin releasers
SSRIs
5-HTP

3-MMC (3-Methylmethcathinone) is a short-acting stimulant of the phenethylamine, amphetamine and cathinone classes. Its effects are very similar to those of mephedrone (4-MMC) but less euphoric, making it the less popular substitution of the two.

Chemistry

3-MMC, or 3-Methylmethcathinone, is a molecule of the substituted cathinone class. Cathinones are a sub-category of amphetamines, sharing share the core amphetamine structure of a phenyl ring bound to an amino (NH2) group through an ethyl chain and an additional methyl substitution at R_α.

3-MMC and other cathinones are differentiated by their ketone substitution on the beta carbon of the amphetamine skeleton, meaning they are β-keto-amphetamines. 3-MMC has two methyl substitutions on its cathinone skeleton, one at R₃ of the phenyl ring, and a second at the nitrogen group R_N. 3-MMC is analogous to mephedrone; it is identical in structure expect for the placement of the methyl group at R₃ instead of R₄.

Pharmacology

Due to the lack of research regarding the substance, all discussion regarding the pharmacology of it is purely based upon its structure and subjective effect similarities to other stimulants such as mephedrone, amphetamine and 2-FMA. 3-MMC most likely acts as both a dopamine and norepinephrine releasing agent. This means it may effectively boost the levels of the norepinephrine and dopamine neurotransmitters in the brain by binding to and partially blocking the transporter proteins that normally remove those monoamines from the synaptic cleft. This allows dopamine and norepinephrine to accumulate within the brain, resulting in stimulating and euphoric effects.

Subjective effects

This subjective effects section is a stub. As such, it is still in progress and may contain incomplete or wrong information. You can help by expanding or correcting it.

The effects listed below are based upon the subjective effects index and personal experiences of PsychonautWiki contributors. The listed effects will rarely (if ever) occur all at once, but heavier dosages will increase the chances and are more likely to induce a full range of effects.

Physical effects

• Spontaneous tactile sensations
• Pupil dilation
• Perception of decreased weight
• Increased perspiration
• Teeth grinding - This component can be considered to be less intense when compared with that of MDMA.

Cognitive effects

• Euphoria
• Empathy, love, and sociability enhancement
• Motivation enhancement
• Anxiety suppression
• Increased music appreciation

Auditory effects

• Auditory enhancement

After effects

The effects which occur during the offset of a stimulant experience generally feel negative and uncomfortable in comparison to the effects which occurred during its peak. This is often referred to as a "comedown" and occurs because of neurotransmitter depletion. Its effects commonly include:

• Anxiety
• Cognitive fatigue
• Depression
• Irritability
• Motivation suppression
• Thought deceleration
• Wakefulness

Toxicity and harm potential

Main article: Research chemicals § Toxicity and harm potential

As with all research chemicals, the long-term effects of 3-MMC haven’t been researched extensively enough to provide accurate information of its risks and harm.

It is strongly recommended that one use harm reduction practices when using this drug.

Tolerance and addiction potential

As with other stimulants, the chronic use of 3-MMC can be considered moderately addictive with a high potential for abuse and is capable of causing psychological dependence among certain users. When addiction has developed, cravings and withdrawal effects may occur if a person suddenly stops their usage. It is said that this compound is considerably more addictive than that of mephedrone.

Tolerance to many of the effects of 3-MMC develops with prolonged and repeated use. This results in users having to administer increasingly large doses to achieve the same effects. After that, it takes about 3 - 7 days for the tolerance to be reduced to half and 1 - 2 weeks to be back at baseline (in the absence of further consumption). 3-MMC presents cross-tolerance with [[Cross-tolerance::all dopaminergic stimulants]], meaning that after the consumption of 3-MMC all stimulants will have a reduced effect.

Dangerous interactions

Warning: Many psychoactive substances that are reasonably safe to use on their own can suddenly become dangerous and even life-threatening when combined with certain other substances. The following list provides some known dangerous interactions (although it is not guaranteed to include all of them).

Always conduct independent research (e.g. Google, DuckDuckGo, PubMed) to ensure that a combination of two or more substances is safe to consume. Some of the listed interactions have been sourced from TripSit.

• "[[DangerousInteraction" contains a listed "[" character as part of the property label and has therefore been classified as invalid.]] & "[[DangerousInteraction" contains a listed "[" character as part of the property label and has therefore been classified as invalid.]] - 25x compounds are highly stimulating and physically straining. Combinations with 3-MMC should be strictly avoided due to the risk of excessive stimulation and heart strain. This can result in increased blood pressure, vasoconstriction, panic attacks, thought loops, seizures, and heart failure in extreme cases.
• "[[UncertainInteraction" contains a listed "[" character as part of the property label and has therefore been classified as invalid.]] - Combining alcohol with stimulants can be dangerous due to the risk of accidental over-intoxication. Stimulants mask alcohol's depressant effects, which is what most people use to assess their degree of intoxication. Once the stimulant wears off, the depressant effects will be left unopposed, which can result in blackouts and severe respiratory depression. If mixing, the user should strictly limit themselves to only drinking a certain amount of alcohol per hour.
• "[[UnsafeInteraction" contains a listed "[" character as part of the property label and has therefore been classified as invalid.]] - Combinations with DXM should be avoided due to its inhibiting effects on serotonin and norepinephrine reuptake. There is an increased risk of panic attacks and hypertensive crisis, or serotonin syndrome with serotonin releasers (MDMA, methylone, mephedrone, etc.). Monitor blood pressure carefully and avoid strenuous physical activity.
• "[[UnsafeInteraction" contains a listed "[" character as part of the property label and has therefore been classified as invalid.]] - Any neurotoxic effects of MDMA are likely to be increased when other stimulants are present. There is also a risk of excessive blood pressure and heart strain (cardiotoxicity).
• "[[UncertainInteraction" contains a listed "[" character as part of the property label and has therefore been classified as invalid.]] - Some reports suggest combinations with MXE may dangerously increase blood pressure and increase the risk of mania and psychosis.
• "[[UncertainInteraction" contains a listed "[" character as part of the property label and has therefore been classified as invalid.]] - Both classes carry a risk of delusions, mania and psychosis, and these risk may be multiplied when combined.
• "[[UnsafeInteraction" contains a listed "[" character as part of the property label and has therefore been classified as invalid.]] - 3-MMC may be dangerous to combine with other stimulants like cocaine as they can increase one's heart rate and blood pressure to dangerous levels.
• "[[DangerousInteraction" contains a listed "[" character as part of the property label and has therefore been classified as invalid.]] - Tramadol is known to lower the seizure threshold and combinations with stimulants may further increase this risk.
• MDMA - The neurotoxic effects of MDMA may be increased when combined with other stimulants.
• Cocaine - This combination may increase strain on the heart.

Serotonin syndrome risk

Combinations with the following substances can cause dangerously high serotonin levels. Serotonin syndrome requires immediate medical attention and can be fatal if left untreated.

• MAOIs - Such as banisteriopsis caapi, syrian rue, phenelzine, selegiline, and moclobemide.
• Serotonin releasers - Such as MDMA, 4-FA, methamphetamine, methylone and αMT.
• SSRIs - Such as citalopram and sertraline
• [[Wikipedia:SNRIs|DangerousInteraction::SNRIs]] - Such as tramadol and venlafaxine
• 5-HTP

Legal issues

This legality section is a stub. As such, it may contain incomplete or wrong information. You can help by expanding it.

Up until recently, 3-MMC was legally and easily obtainable to most people by ordering online. Some countries had found ways to include it within other drug acts, but most had not banned the specific chemical nor included its structure or use within bigger law articles.

• China - Since October 2015, the drug has been banned (along with an enormous amount of other chemicals) in China. Due to this ban, many chemicals have become increasingly difficult to attain since the manufacturing was mainly done by Chinese chemical companies.
• Czeck republic - 3-MMC is banned in the Czech Republic.
• United Kingdom - It is illegal to produce, supply, or import this drug under the Psychoactive Substance Act, which came into effect on May 26th, 2016.
• Germany - On December 13th, 2014, 3-MMC was added to the controlled substance act ("BtMG"), making it illegal to produce, sell or possess.

Experience reports

Anecdotal reports which describe this compound within our experience index include:

• Experience:3-MMC: Weak substitute? No way!
• Experience:35mg Dextromethamphetamine + 305mg 3-Methylmethcathinone + 20mg 2C-B - destroying myself before rebuilding

See also

• Responsible use
• Stimulants
• Cathinones
• Amphetamine
• MDMA
• Cocaine

External links

• 3-MMC (Wikipedia)
• 3-MMC Experiences (Erowid)
• 3-MMC (Bluelight)
• 3-MMC (Tripsit)