Substituted amphetamines

General formula of an amphetamine molecule.

Substituted amphetamines, also known as amphetamines, are a class of chemicals that include compounds with psychoactive effects.

Chemistry

Substituted amphetamines are a chemical class based upon the molecule amphetamine. Amphetamine is made up of a phenethylamine molecule. The chemical structure of a substituted amphetamine is the same as the organic molecule amphetamine, except some substitutions are made at the phenyl and amine sites, typically of methyl and ethyl chains.

Pharmacology

The substituted amphetamine class of psychedelic, entactogenic and stimulant drugs works via their action upon numerous receptors. Psychedelic effects can be attributed to action on the 5-HT_2A receptor. Entactogenic and stimulant effects are due to their action as releasing agents of serotonin, adrenaline and noradrenaline or as agonists on the receptors of the previous neurotransmitters. The agonism of this set of receptors leads to an increased rate firing of the post-synaptic neuron, triggering both cognitive and physical stimulation within the user.

List of substituted amphetamines

Note: This list does not include phenidates, cathinones, MDxxs, Benzofurans or aminoindanes.

Compound	R2	R3	R4	R5	RN	Structure
2-FA	F	H	H	H	H
2-FMA	F	H	H	H	CH3
4-FA	H	H	F	H	H
Bromo-DragonFLY	OCH=CH-	-	Br	OCH=CH-	H
DOB	OCH3	H	Br	OCH3	H
DOC	OCH3	H	Cl	H	OCH3
DOI	OCH3	H	I	H	OCH3
DOM	OCH3	H	CH3	H	OCH3
Amphetamine	H	H	H	H	H
Lisdexamfetamine	H	H	H	H	C(=O)CH(NH2)CH2CH2CH2CH2NH2
Methamphetamine	H	H	H	H	CH3

See also

• Responsible use
• Psychedelics
• Phenethylamines
• Entactogens
• Stimulants

References

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