Warning
This is an unofficial archive of PsychonautWiki as of 2025-08-11T15:14:44Z. Content on this page may be outdated, incomplete, or inaccurate. Please refer to the original page for the most up-to-date information.

Escaline

From PsychonautWiki Archive
Revision as of 05:37, 6 May 2016 by >Oskykins (Text replacement - "{{Main|Research chemicals#Toxicity and harm potential}}" to "{| |- | 17px''Main articles: Research chemicals § Toxicity and harm potential'' ''&'' ''Responsible use § Hallucinogens'' |}")
Jump to navigation Jump to search
Escaline
Chemical Nomenclature
Common names Escaline
Substitutive name 3,5-methoxy-4-ethoxyphenethylamine
Systematic name 2-(4-Ethoxy-3,5-dimethoxy-phenyl)-ethylamine
Class Membership
Psychoactive class Psychedelic
Chemical class Phenethylamine
Routes of Administration

WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section.



⇣ Oral
Dosage
Threshold 20 mg
Light 30 - 50 mg
Common 50 - 100 mg
Strong 100 - 150 mg
Heavy 150 mg +
Duration
Total 8 - 12 hours
Onset 90 - 120 minutes
After effects 3 - 5 hours









DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.

Interactions
Summary sheet: Escaline

Escaline, or 3,5-methoxy-4-ethoxyphenethylamine, is a psychedelic drug and entheogen of the phenethylamine class of compounds. Escaline was first synthesized and reported in the scientific literature by Benington, et al., in 1954, but was later re-examined in the laboratory of David E. Nichols who prepared a series of mescaline analogues that includes escaline, proscaline, and isoproscaline.

The effects of escaline were first described by Alexander Shulgin in his book PiHKAL: A Chemical Love Story. He lists the dosage range as 40mg to 60mg orally and describes the duration of action to be 8 - 12 hours.[1] Shulgin states that escaline “differs from mescaline in that the onset of action is quicker (within the first hour) and there is no nausea noted, but otherwise the time course, and much of the qualitative content, is quite similar.”. [2]

Chemistry

This chemistry section is incomplete.

You can help by adding to it.

Escaline is the phenethylamine analog of 3C-E and the 4-ethoxy analog of mescaline.

Pharmacology

Main article: Serotonergic psychedelic

Escaline's agonist activity at the serotonin 5-HT2A receptor is known to be 5-8 times greater than that of mescaline. [3][4] The effects of this compound are believed to come from its efficacy at the 5-HT2A receptor as a partial agonist. However, the role of these interactions and how they result in the psychedelic experience continues to remain elusive.

Subjective effects

The effects listed below are based upon the subjective effects index and personal experiences of PsychonautWiki contributors. The listed effects will rarely (if ever) occur all at once, but heavier dosages will increase the chances and are more likely to induce a full range of effects.

Physical effects

Cognitive effects

Visual effects

Enhancements

Distortions

Geometry

Hallucinatory states

Auditory effects

Toxicity and harm potential

Main articles: Research chemicals § Toxicity and harm potential & Responsible use § Hallucinogens

The toxicity and long-term health effects of recreational escaline use do not seem to have been studied in any scientific context and the exact toxic dose is unknown. This is because escaline is a research chemical with very little history of human usage. Anecdotal evidence from people within the psychonaut community who have tried escaline suggests that there are no negative health effects attributed to simply trying the drug by itself at low to moderate doses and using it very sparingly (but nothing can be completely guaranteed). Independent research should always be done to ensure that a combination of two or more substances is safe before consumption. It is strongly recommended that one use harm reduction practices when using this drug.

Tolerance and addiction potential

Escaline is not habit-forming and the desire to use it can actually decrease with use. It is most often self-regulating.

Tolerance to the effects of escaline are built almost immediately after ingestion. After that, it takes about 3 days for the tolerance to be reduced to half and 7 days to be back at baseline (in the absence of further consumption). Escaline presents cross-tolerance with [[Cross-tolerance::all psychedelics]], meaning that after the consumption of escaline all psychedelics will have a reduced effect.

This legality section is a stub.

As such, it may contain incomplete or wrong information. You can help by expanding it.

  • United States: Escaline is unscheduled in the U.S., but may be illegal via the Federal Analog Act.

See also

References

  1. ↑ www.erowid.org/library/books_online/pihkal/pihkal072.shtml | #72 E; ESCALINE
  2. ↑ https://www.erowid.org/archive/rhodium/chemistry/shulgin.pea.sar.hop.html | Psychotomimetic Drugs: Structure-Activity Relationships
  3. ↑ http://www.ncbi.nlm.nih.gov/pubmed/18666267 | Structure-activity relationships of phenylalkylamines as agonist ligands for 5-HT(2A) receptors.
  4. ↑ https://www.erowid.org/archive/rhodium/chemistry/shulgin.pea.sar.hop.html | Psychotomimetic Drugs: Structure-Activity Relationships
Retrieved from "http://psy.st/w/index.php?title=Escaline&oldid=60055"