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Benzydamine

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Benzydamine
Chemical Nomenclature
Common names Benzydamine, Tantum Verde
Substitutive name Benzydamine
Systematic name 3-(1-Benzyl-1H-indazol-3-yloxy)-N,N-dimethylpropan-1-amine
Class Membership
Psychoactive class Deliriant / Stimulant
Chemical class Indazole
Routes of Administration

WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section.



Oral
Dosage
Threshold 150 mg
Light 300 - 500 mg
Common 500 - 1000 mg
Strong 1000 - 2000 mg
Heavy 2000 mg +
Duration
Total 5 - 8 hours
Onset 20 - 60 minutes
Peak 3 - 6 hours
Offset 3 - 8 hours
After effects 24 - 72 hours









DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.

Interactions
Summary sheet: Benzydamine

Benzydamine (also known as Tantum Verde) is a topical anaesthetic of the benzyl-indazole chemical class. It is commonly found in small doses in over-the-counter products used to treat sore throats. In Germany and Poland, it is sold as a vaginal douching agent under the brand name Tantum Rosa. This product is also freely available across the world through the use of online stores such as eBay.

Alternatively, benzydamine can be used as a powerful psychoactive hallucinogen for recreational or entheogenic purposes. In high doses, it acts as a unique deliriant and CNS stimulant.[1] Such use, particularly among teenagers, has been reported in Poland,[2] Brazil[3][4] and Romania.

Chemistry

Benzydamine, or 3-(1-benzylindazol-3-yl)oxy-N,N-dimethylpropan-1-amine, is a synthetic benzyl-indazole molecule. Benzydamine contains a benzene and pyrazole ring fused to form a bicyclic indazole group. A benzyl substituent C6H5CH2- is bound to R1 of the indazole ring. This indazole ring is also substituted at R3 with an ether chain consisting of the oxygen group bonded to a propyl amine chain. The terminal amine RN of this structure is substituted with two methyl groups (dimethyl). Benzydamine is produced as a hydrochloride salt.

Pharmacology

Benzydamine is a locally acting nonsteroidal anti-inflammatory drug with local anaesthetic and analgesic properties. Unlike other NSAIDs, it does not inhibit cyclooxygenase or lipooxygenase and is not ulcerogenic.

In terms of the pharmacology behind its hallucinogenic effects, this aspect of benzydamine remains unstudied and is subject to much speculation.

Subjective effects

This subjective effects section is a stub.

As such, it is still in progress and may contain incomplete or wrong information.

You can help by expanding or correcting it.

Physical effects

Visual effects

Cognitive effects

Auditory effects

Toxicity and harm potential

The vaginal douching agents such as Tantum Rosa and other products consistently contain large amounts of salt which, if consumed, can cause serious kidney damage.

Extraction

Benzydamine is usually extracted from Tantum Rosa douching agents which are available online. In order to consume the substance safely, one must first remove the dangerous levels of salt contained within the sachet. This can be done by dissolving the substance in a small amount of water (25ml/sachet) and filtering through a paper filter. The salt will dissolve in water to create a saturated solution. The powder left on the filter can then be dried and consumed by either eating or dissolving it in liquid and drinking. It is not advised to drink the water used to dissolve the salt.[5]

Benzydamine is legal and available in over-the-counter preparations in most parts of the world.

See also

References

  1. Recreational abuse with benzydamine hydrochloride (tantum rosa) | http://www.ncbi.nlm.nih.gov/pubmed/17364645
  2. Recreational abuse with benzydamine hydrochloride (tantum rosa) | http://www.ncbi.nlm.nih.gov/pubmed/17364645
  3. Recreational use of benzydamine as a hallucinogen among street youth in Brazil | http://www.ncbi.nlm.nih.gov/pubmed/19784487
  4. Use abusive of benzydamine in Brazil: an overview in pharmacovigilance | http://www.ncbi.nlm.nih.gov/pubmed/19784487
  5. http://hyperreal.info/node/2265 (Polish)