5F-PB-22

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5F-PB-22
Chemical Nomenclature
Substitutive name	5F-PB-22
Systematic name	1-pentyfluoro-1H-indole-3-carboxylic acid 8-quinolinyl ester
Class Membership
Psychoactive class	Cannabinoid
Chemical class	Indolecarboxylate
Routes of Administration
WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section. ⇣ Smoked Dosage Threshold 1 mg Light 1 - 3 mg Common 3 - 5 mg Strong 5 - 8 mg Heavy 8 mg + Duration Total 90 minutes Onset 10 seconds Peak 30 minutes Offset 1 hour After effects 15 minutes ⇣ Oral Dosage Threshold 1 mg Light 1 - 3 mg Common 3 - 5 mg Strong 5 - 8 mg Heavy 8 mg + Duration Total 2 - 3 hours Onset 30 minutes Peak 1.5 hours Offset 1 hours After effects 30 minutes DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.
Interactions

Template:Proofread 5F-PB-22 (1-pentyfluoro-1H-indole-3-carboxylic acid 8-quinolinyl ester) is a synthetic cannabinoid and agonist of the cannabinoid receptor which produces predominantly sedating subjective effects somewhat similar to that of cannabis. There is very little information regarding the pharmacology of this compound within the scientific literature. Despite this, however, it has been sold as a grey area research chemical through online vendors.

When smoked or vaporized, this substance produces effects in humans and animals similar to those of THC, a cannabinoid naturally present in cannabis.

Chemistry

5F-PB-22, or Quinolin-8-yl 1-pentyfluoro-1H-indole-3-8-carboxylate, belongs to a structural class of substances including PB-22, 5F-PB-22, JWH-018, and AM2201 which contain a core indole structure. The core indole of 5F-PB-22 is substituted at the 1- and 3- positions with a pentylfluoro and 8-carboxylate respectively.

Pharmacology

Although this substance has not been formally studied, from analysis of the structure, it is presumed that 5F-PB-22 has a similar binding profile to that of other cannibanoids and matches many of the in vivo properties of Δ9-THC.

Subjective effects

The effects listed below are based upon the subjective effects index and personal experiences of PsychonautWiki contributors. The listed effects will rarely if ever occur all at once but heavier dosages will increase the chances and are more likely to induce a full range of effects.

Physical effects

• Spontaneous tactile sensations - The body high of 5F-PB-22 can be described as a warm and soft pleasurable, all-encompassing tingling sensation that spreads over the body. It maintains a consistent presence that quickly rises with the onset and hits its limit once the peak has been reached before immediately dissipating.
• Sedation - Generally, the effects on the user's energy levels are very sedating. This encourages one to relax, lay down, and at higher doses fall asleep. It produces strong sedative effects that can be described as on par with JWH-018 and more sedating when compared to THC, JWH-073 THJ-018, AM-2201, or 5F-UR-144, but less than that of 5F-AKB-48.
• Motor control loss - This substance causes a partial to moderate suppression of motor control which intensifies proportional to dosage but rarely results in a complete inability to walk and perform basic movements.
• Appetite enhancement - As with many other cannabinoids, 5F-PB-22 causes an increase in appetite, known colloquially as "the munchies" in popular American and United Kingdom culture. Clinical studies and survey data have found that cannabis increases food enjoyment and interest in food. This is thought to be due to the way in which endocannabinoids in the hypothalamus activate cannabinoid receptors that are responsible for maintaining food intake.
• Dehydration- This is known colloquially as "cotton mouth" in popular American and United Kingdom culture.
• Vasodilation - Cannabinoids appear to decrease blood pressure by dilating the blood vessels and increasing blood flow throughout the body. The arteries in the eyeball expand from the decreased blood pressure and the heart rate increases to compensate for the reduction in pressure.
• Pain relief - Cannabinoids have been clinically demonstrated to provide pain relief via agonism of cannabinoid receptors CB₁ and CB₂, which extends to synthetic cannabinoid receptor agonists.
• Increased bodily weight or Decreased bodily weight
• Changes in gravity - 5F-PB-22, like other cannabinoids, is capable of causing vertigo with which the environment appears to be spinning or oscillating. At moderate doses, it can spontaneously induce the sensation of falling, which can be overwhelming and uncomfortable. The propensity of this is greatly reduced and eliminated in proportion to tolerance.
• Salivation
• Increased heart rate

Cognitive effects

• Current mind state enhancement - The most prominent cognitive component of the cannabinoids is the way in which they enhance the emotions one is already feeling proportional to dosage. This can result in euphoria, extreme laughter, or increased immersion within tasks and activities or it can result in anxiety or paranoia depending on the user's current mind state.
• Euphoria - This can be considered very prominent in comparison to THJ-018, AM-2201, and 5F-UR-144, but less intense in comparison to JWH-073.
• Thought connectivity - This can attribute to fluid, more abstract thinking in comparison to linear thought.
• Anxiety - Subjectively, 5F-PB-22 is less anxiogenic and stimulating than Δ9-THC, THJ-018, AM-2201, or 5F-UR-144, but more so than JWH-073 or JWH-018.
• Paranoia - All cannabinoids are capable of inducing paranoia at high doses, or with chronic administration.
• Thought deceleration
• Conceptual thinking
• Mindfulness
• Information processing suppression
• Dream suppression
• Immersion enhancement

Visual effects

• Colour enhancement
• Acuity suppression
• Geometry - As reported with other cannabinoids, 5F-PB-22 can produce closed eye visuals at moderate doses, which can escalate into visual distortions such as a ripples in the field of vision upon continuous administration. Within users who also regularly use psychedelics, it is capable of inducing these consistently in a visual style which seems to be an averaged out depiction of all the psychedelics one has used within the past. These rarely extend beyond level 4 and are considered to be mild, fine, small and zoomed out but brighter and better defined than the geometry experienced with cannabis, but not as defined as other synthetic cannabinoids such as JWH-018 or JWH-073

Auditory effects

• Enhancements

Combinational effects

• Psychedelics - When used in combination with psychedelics, cannabinoids are capable of intensifying and extending the duration of both the visual and cognitive effects with extreme efficiency. This should be used with caution if one is not experienced with psychedelics.
• Dissociatives - When used in combination with dissociatives, the geometry, euphoria, dissociation and hallucinatory effects are often greatly enhanced.
• Alcohol - When used in combination with alcohol, cannabinoids can cause feelings of extreme nausea, dizziness and changes in gravity. It is recommended that one smoke before drinking and not the other way around unless they are extremely cautious.

Toxicity and harm potential

Since 5F-PB-22 is a relatively new substance, there is very little data available about its toxicity or addiction potential.There have been many hospital reports of overdoses and panic Informal experiments have shown that overdose will cause physical discomfort including heart palpitations, vertigo and sedation at much lower than dangerous doses, usually causing the user to fall asleep. There have been many hospital reports involving 5F-PB-22, aswell as atleast 4 cases of post-mortem analysis involing 5F-PB-22.

As the material is active in the milligram range, it is important to remain vigilant when dosing as to avoid a negative experience.

Lethal dosage

The precise lethal dosage of this substance is unknown. It is thought to be extremely variable and unpredictable between individuals.

Tolerance and addiction potential

This substance is potentially addictive and the sudden cessation of prolonged chronic usage can result in extreme and uncomfortable withdrawal symptoms. Tolerance to the substance develops quite rapidly, so successive daily use will require the dose to be increased very slightly to achieve the same effects. It also has cross-tolerance with other cannabinoids.

Legal issues

• United States: In January 2014, 5F-PB-22 was designated as a Schedule I controlled substance in the United States

5F-PB-22 was developed to bypass drug prohibition laws which have banned the possession and sale of many synthetic cannabinoids. As such, it remains legal in most of the world.

See also

• JWH-018
• THJ-018
• AM-2201
• 5F-AKB-48
• Synthetic Cannabinoid
• Cannabis