4-FA

4-FA
Chemical Nomenclature
Common names	4-FA, 4-FMP, PAL-303, Flux
Substitutive name	4-Fluoroamphetamine, para-Fluoroamphetamine
Systematic name	(RS)-1-(4-Fluorophenyl)-N-propan-2-amine
Class Membership
Psychoactive class	Stimulant / Entactogen
Chemical class	Amphetamine
Routes of Administration
WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section. ⇣ Oral Dosage Threshold 40 mg Light 40 - 100 mg Common 100 - 130 mg Strong 130 - 150 mg Heavy 150 mg + Duration Total 5 - 8 hours Onset 45 - 75 minutes Come up 30 - 75 minutes Peak 2.5 - 3.5 hours Offset 2 - 3 hours After effects 6 - 12 hours DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.
Interactions
Alcohol
GHB
GBL
Opioids
Cannabis
Caffeine
Ketamine
Methoxetamine
Psychedelics
Cocaine
DXM
PCP
25x-NBOMe
2C-T-x
5-MeO-xxT
DOx
Tramadol
aMT
MAOIs

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4-Fluoroamphetamine (4-FA) is a substituted amphetamine with stimulant, enactogenic and nootropic effects. It is rarely found on the streets but commonly sold as a grey area research chemical through online vendors.

Chemistry

4-Fluoroamphetamine (2-FA) is a phenethylamine of the substituted amphetamine family. It contains a fluorine bound to C₄ of the phenyl group.

Pharmacology

4-Fluoroamphetamines pharmacology differs based on the amount of substance consumed. When 100mgs or more is introduced 4-FA acts as releasing agent and reuptake inhibitor of dopamine, serotonin, and norepinephrine, producing euphoric, enactogenic effects similar to MDMA. When lower doses of >75mg are ingested it only acts on dopamine and norephinephrine, producing effects more similar to a functional stimulant. The mechanism of action of 4-FA effectively boosts the levels of the norepinephrine, dopamine, and serotonin [[neurotransmitters] in higher doses in the brain, by binding to, and partially blocking the transporter proteins that normally remove those monoamines from the synaptic cleft. This allows dopamine, norepinephrine and serotonin to accumulate within the brain, resulting in stimulating and euphoric effects.

Studies demonstrate that 4-flourine amphetamine substitutions limit activity of the compound at the alpha-1 adrenergic receptor with an over 200-fold increased selectivity for A2 receptors over A1 receptors. It has also been demonstrated that 4-substitution of a hydrogen with fluorine on the aromatic ring of norepinephrine produces a beta-adrenergic agonist with little alpha activity. This has lead the online community to speculate that the milder uncomfortable cognitive and/or physical side effects and greater efficacy as a a nootropic associated with this substance are at least partially due to decreased activity at the alpha-1 adrenergic receptors resulting in significantly less norepinephrine reuptake inhibition.

Subjective effects

In comparison to other substituted amphetamines, 4-FA is particularly free of side effects such as nausea, high blood pressure, anxiety and an uncomfortable offset. Im low doses it is considered to be an extremely functional and effective nootropic for performing tasks general productivity of any sort. At higher dosages however, it becomes dysfunctional and recreational due to the intensity of its euphoria and stimulation.

The effects listed below are based upon the subjective effects index and personal experiences of PsychonautWiki contributors. The listed effects will rarely if ever occur all at once but heavier dosages will increase the chances and are more likely to induce a full range of effects.

Physical effects

• Stimulation
• Tactile enhancement
• Physical euphoria
• Dehydration
• Appetite suppression
• Increased heart rate

Cognitive effects

• Thought acceleration
• Focus enhancement
• Anxiety suppression
• Wakefulness
• Analysis enhancement
• Motivation enhancement
• Compulsive redosing
• Cognitive exhaustion - This component can occur during the offset of this compound as a rebound effect which is usually equal in its intensity to the enhancements which occurred before it.

Toxicity and harm potential

The toxicity and long term health effects of recreational 2-FMA use does not seem to have been studied in any scientific context and the exact toxic dosage is unknown. This is because 2-FMA is a research chemical with very little history of human usage. Anecdotal evidence from people within the psychonaut community who have tried 2-FMA suggests that there are no negative health effects attributed to simply trying this drug at low to moderate doses or using it very sparingly (but nothing can be completely guaranteed).

Tolerance and addiction potential

Tolerance develops rapidly with repeated usage, so periods of extended use require increasing doses of the drug in order to achieve the same effect. Addiction is a serious risk with heavy recreational use of any substituted amphetamine and compulsive redosing is extremely common.

Psychosis

Abuse of amphetamines at high dosages for prolonged periods of time can result in a stimulant psychosis that may present with a variety of symptoms (e.g., paranoia, hallucinations, delusions). A Cochrane Collaboration review on treatment for amphetamine, dextroamphetamine, and methamphetamine abuse-induced psychosis states that about 5–15% of users fail to recover completely. The same review asserts that, based upon at least one trial, antipsychotic medications effectively resolve the symptoms of acute amphetamine psychosis. Psychosis very rarely arises from therapeutic use.

Legal issues

2-FMA is currently a grey area compound within all parts of the world. This means that it is not known to be specifically illegal within any country but that people may still be charged for its possession under certain circumstances such as under analogue laws and with intent to sell or consume.

See also

• Stimulants
• Amphetamine
• Methamphetamine