MDAI

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MDAI
Chemical Nomenclature
Common names	MDAI
Substitutive name	5,6-Methylenedioxy-2-aminoindane
Systematic name	6,7-Dihydro-5H-cyclopenta[f][1,3]benzodioxol-6-amine
Class Membership
Psychoactive class	Entactogen
Chemical class	Aminoindane / MDxx
Routes of Administration
WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section. ⇣ Oral Dosage Threshold 40 mg Light 40 - 100 mg Common 100 - 175 mg Strong 175 - 300 mg Heavy 300 mg + Duration Total 4 - 6 hours Onset 20 - 40 minutes Come up 30 - 60 minutes Peak 2 - 2.5 hours Offset 1 - 2 hours DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.
Interactions
MAOIs
Serotonin releasers
SSRIs
5-HTP

MDAI (5,6-Methylenedioxy-2-aminoindane) is a drug developed in the 1990s by a team led by David E. Nichols at Purdue University. It acts as a non-neurotoxic and highly selective serotonin releasing agent (SSRA) which produces entactogen effects in humans similar to that of MDMA.

Chemistry

The chemical structure of MDAI is indirectly derived from that of the illicit drug MDA, but the alpha-methyl group of the alkylamino amphetamine side chain has been bound back to the benzene nucleus to form an indane ring system, which changes its pharmacological properties substantially.

Pharmacology

MDAI has been shown to inhibit the reuptake of serotonin, dopamine, and norepinephrine. This demonstrates that MDAI has selective affinity for the serotonin receptor. Studies show that the brains of animals treated with MDAI have greater extracellular concentrations of monoamine neural transmitters resulted, most significantly serotonin. This result indicates that MDAI is a potent releaser of serotonin, while effectively inhibiting the reuptake of serotonin. For comparison, MDAI is similar in potency with releasing serotonin to MDA but significantly less potent than MDMA.

Subjective effects

The effects listed below are based upon the subjective effects index and personal experiences of PsychonautWiki contributors. The listed effects will rarely if ever occur all at once but heavier dosages will increase the chances and are more likely to induce a full range of effects.

Physical effects

The physical effects of MDAI can be broken down into seven components all of which progressively intensify proportional to dosage. These are described below and generally include:

• Euphoria
• Enhancement of touch
• Stimulation and Sedation -The biggest difference between MDAI and MDMA is that due to a comparative lack of dopamine reuptake inhibition, MDAI is only subtly stimulating at points but also can often induce moderate sedation.
• Spontaneous tactile sensations - The "body high" of MDAI can be described as a moderate to extreme euphoric tingling sensation that encompasses the entire body. It is capable of becoming overwhelmingly pleasurable at higher dosages. This sensation maintains a consistent presence that steadily rises with the onset and hits its limit once the peak has been reached.
• Dehydration - Feelings of dry mouth and dehydration are a universal experience with MDAI; this effect is a product of an increased heart rate and an extreme motivation to engage in strenuous physical activities. While it is important to avoid becoming dehydrated, especially when out dancing in a hot environment, there have been a number of users suffering from water intoxication through over-drinking so it is advised that users simply sip at water and never over-drink.
• Vibrating vision - At high dosages, a person's eyeballs may even begin to spontaneously wiggle back and forth in a rapid motion, causing the vision to become blurry and temporarily out of focus-- a condition known as nystagmus.

Cognitive effects

The cognitive effects of MDAI can be broken down into six components all of which progressively intensify proportional to dosage. The general head space of MDAI is described by many as one of extreme mental stimulation, feelings of love or empathy and powerful euphoria. It contains a large number of typical entactogenic cognitive effects.

The most prominent of these cognitive effects generally include:

• Euphoria - Strong emotional euphoria and feelings of happiness are present within MDAI and are a direct result of serotonin and dopamine release.
• Increased empathy, love and sociability - This particular effect is equally as pronounced, powerful and therapeutic as that of MDMA or 2C-B. It is the most obvious and noticeable effect within any MDAI experience and dominates the head space.
• Acceleration of thought
• Mindfulness

Toxicity and Harm Potential

MDAI and other similar drugs have been widely used in scientific research, as they are able to replicate many of the effects of MDMA, but without causing the neurotoxicity which may be associated with MDMA and some related drugs. No tests have been performed on cardiovascular toxicity.