This is an unofficial archive of PsychonautWiki as of 2025-08-11T15:14:44Z. Content on this page may be outdated, incomplete, or inaccurate. Please refer to the original page for the most up-to-date information.
Talk:Thebaine
From PsychonautWiki Archive
Revision as of 09:25, 13 February 2021 by >Benjaminbardsley(added content)
This article is in the 'Talk' namespace because it is an unfinished draft. This section is used to host drafts for unpublished articles as well as discussions for published ones. If you'd like to use this area to discuss this draft, please do so in the 'Discussion' section at the very bottom of the page. This notice will be removed once this draft has been approved for publication by an administrator.
Substance Breakdown
Chemical Nomenclature
Common names
Thebaine, Opium
Substitutive name
Paramorphine
Systematic name
dehydromorphine 3,6-dimethyl ether.
Class Membership
Psychoactive class
Opioid/Stimulant
Chemical class
Morphian
Routes of Administration
WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section.
⇣ Oral
Dosage
Bioavailability
x% - y%
[1]
Threshold
10 mg
Light
15 - 30 mg
Common
30 - 60 mg
Strong
60 - 100 mg
Heavy
100 mg +
Duration
Total
x - y hours
Onset
15 - 30 minutes
Come up
10 - 20 minutes
Peak
1 - 2 hours
Offset
2 - 4 hours
After effects
8 - 12 hours
DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.
As a result, it may contain incomplete or wrong information. You can help by expanding it.
Chemistry
Thebaine (paramorphine), also known as codeine methyl enol ether, is an opiate alkaloid naturally occurring in opium poppies.
Pharmacology
thebaine is chemically similar to both morphine and codeine, but has stimulatory rather than depressant effects. At high doses, it causes convulsions similar to strychnine poisoning. The synthetic enantiomer (+)-thebaine does show analgesic effects apparently mediated through opioid receptors, unlike the inactive natural enantiomer (−)-thebaine.[3] While thebaine is not used therapeutically, it is the main alkaloid extracted from Papaver bracteatum (Iranian opium / Persian poppy) and can be converted industrially into a variety of compounds, including hydrocodone, hydromorphone, oxycodone, oxymorphone, nalbuphine, naloxone, naltrexone, buprenorphine and etorphine. Butorphanol can also be derived from thebaine.[4]
Disclaimer: The effects listed below cite the Subjective Effect Index (SEI), an open research literature based on anecdotal user reports and the personal analyses of PsychonautWikicontributors. As a result, they should be viewed with a healthy degree of skepticism.
It is also worth noting that these effects will not necessarily occur in a predictable or reliable manner, although higher doses are more liable to induce the full spectrum of effects. Likewise, adverse effects become increasingly likely with higher doses and may include addiction, severe injury, or death ☠.
{{effects/base
|
Physical effects
Stimulation or Sedation.
a predominant effect of thebaine is central nervous system stimulation which can result in an inability to sleep and restlessness, the stimulation caused by thebaine can be described as uncomfortable rather than euphoric, as seen with substances like morphine and oxycodone, in addition sedation is occasionally experienced during the offset of the experience largely due to the metabolite oripavine.
Thebaine can cause a user to be unable to sleep due to its stimulant properties.
Seizures
thebaine has been reported to cause seizures at doses above 2mg/kg in lab animals similar to strychnine poisoning.
Hypotension
thebaine has been reported to lower blood pressure in animal studies.
{{effects/visual|
Visual effects are rarely experienced although sometimes they can occur as a result of sleep deprivation caused by the drug or as a result of the blood pressure lowering effect.
Distortions
Double Vision
This effect is rare and usually only occurs during offset of a high dosage.
Thebaine raises anxiety due to its CNS stimulant and excitetory activity, occasionally it may suppress anxiety which is likely due to the metabolite, oripavine.
Thebaine is very toxic and high doses produce symptoms similar to strychnine poisoning.
It is strongly recommended that one use harm reduction practices when using this substance.
Lethal dosage
Tolerance and addiction potential
Thebaine is considered of low abuse potential due to its toxic effects on the body.
Warning:Many psychoactive substances that are reasonably safe to use on their own can suddenly become dangerous and even life-threatening when combined with certain other substances. The following list provides some known dangerous interactions (although it is not guaranteed to include all of them).
Always conduct independent research (e.g. Google, DuckDuckGo, PubMed) to ensure that a combination of two or more substances is safe to consume. Some of the listed interactions have been sourced from TripSit.
Legal status
Thebaine is controlled under international law, is listed as a Class A drug under the Misuse of Drugs Act 1971 in the United Kingdom, is controlled as an analog of a Schedule II drug per the Analog Act in the United States, and is controlled with its derivatives and salts, as a Schedule I substance of the Controlled Drugs and Substances Act in Canada.[5] The 2013 US Drug Enforcement Administration (DEA) aggregate manufacturing quota for thebaine (ACSCN 9333) was unchanged from the previous year at 145 metric tons.
See also
Use of this compound is not recommended due to its negative effects and toxicity.
Chemical Nomenclature
Common names
Thebaine, Opium
Substitutive name
Paramorphine
Systematic name
dehydromorphine 3,6-dimethyl ether.
Class Membership
Psychoactive class
Opioid/Stimulant
Chemical class
Morphian
Routes of Administration
WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section.
