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Anxiety suppression
Anxiety suppression (also known as anxiolysis[1]) is a partial to complete suppression of a person’s ability to feel anxiety, general unease, and negative feelings of psychological tension.[2][3] The experience of this effect may decrease anxiety-related behaviours such as rumination, muscular tension, panic attacks, and restlessness. This typically results in feelings of extreme calmness and relaxation.
Anxiety suppression is often accompanied by other coinciding effects such as disinhibition and sedation. It is most commonly induced under the influence of moderate dosages of anxiolytic compounds which primarily include GABAergic depressants,[4][5] such as benzodiazepines,[6] alcohol,[7] GHB,[8] and gabapentinoids[9]. However, it can also occur to a lesser extent under the influence of a large variety of other pharmacological classes which include but are not limited to opioids, dissociatives,[10] and SSRIs.
Psychoactive substances
Compounds within our psychoactive substance index which may cause this effect include:
- 1,4-Butanediol
- 2-FA
- 2M2B
- 3-Cl-PCP
- 3-FA
- 3-FEA
- 3-FMA
- 3-HO-PCE
- 3-HO-PCP
- 3-MMC
- 3-MeO-PCE
- 3-MeO-PCMo
- 3-MeO-PCP
- 4-AcO-DiPT
- 4-FA
- 4-MeO-PCP
- 5-Hydroxytryptophan
- 6-APB
- 6-APDB
- Acetylfentanyl
- Alcohol
- Alprazolam
- Amanita muscaria
- Aniracetam
- Armodafinil
- Baclofen
- Barbiturates
- Benzodiazepines
- Bromantane
- Bromazepam
- Buprenorphine
- Cannabidiol
- Cannabis
- Carisoprodol
- Clonazepam
- Clonazolam
- Clonidine
- Codeine
- Coluracetam
- Creatine
- Cyclazodone
- Deschloroetizolam
- Deschloroketamine
- Desomorphine
- Desoxypipradrol
- Dextromethorphan
- Dextropropoxyphene
- Diazepam
- Diclazepam
- Dihydrocodeine
Experience reports
Anecdotal reports which describe this effect within our experience index include:
- Experience: 36mg 4-AcO-DiPT - Truly, one for the psychedelic animals among us
- Experience: 660ug LSD - First bad trip
- Experience:100 mg- Actually Lifechanging
- Experience:120µg LSD - First Bad Acid Trip, Psychosis
- Experience:150mg MDMA + 20mg 2C-B - I designed it this way myself
- Experience:20mg (insufflated) - permanent all-encompassing states of unity and interconnectedness
- Experience:20mg Etizolam - Smoking Etizolam
- Experience:225mg Pregabalin +Cannabis -Bliss and Serenity; a hedonistic evening
- Experience:25mg 2C-B - Hard raving at home
- Experience:25mg Quetiapine - Nice buzz
- Experience:260 mg Ketamine (insufflated) - Lost in Paisley
- Experience:2C-P (approx. 35mg) - Asymmetrical Terror and the Geometric Sea
- Experience:2mg 25C-NBOMe - Experimental trip to test personal limits of NBOMes
- Experience:2mg Etizolam - Here be dragons
- Experience:3 bowls of cannabis indica - I wrote down unintelligible gibberish
- Experience:3-MMC: Weak substitute? No way!
- Experience:3.5g psilocybe cubensis - Relinquishing of Material Chains/Fear and Desolation
- Experience:300mg DXM + 25mg DMT + Cannabis - A crazy night
- Experience:300ug LSD - Profound religious experience
- Experience:300µg LSD - Togetherness and the Silent Dusk
- Experience:3mg Etizolam - A Comedown Drug
- Experience:40mg Zolpidem / 20mg Diazepam - Please Don't Do This
- Experience:60mg 4-AcO-DMT Nonstop Quasi-Orgasmic Objectless Euphoria
- Experience:60mg Zolpidem - A Delirious Adventure
- Experience:70mg Lisdexamfetamine (oral) - My first stimulant experience
- Experience:7500mg - Analysis of gabapentin
- Experience:800 seeds LSA - My First Trip Ever
- Experience:An experiement combining mangoes and cannabis
- Experience:BK-2C-B - Various experiences
- Experience:DXM and Cannabis: 100mg - Unexpected Strong Trip
- Experience:Datura and nicotine smoked - 4 and ~15 hits; was actually quite pleasant
- Experience:Diazepam (20/10mg, Oral) - Comfortably Drunk
- Experience:Kratom + Phenibut + Cannabis - Warm Bliss
- Experience:MXE: 37.5 mg - Calm and Cloudy Bliss
- Experience:Mushrooms (~0.5 g) - Autonomous Voice
- Experience:Nightmare flipping
- Experience:Psilocybin Mushroom (0.16 g, Oral) - Dosage Independent Intensity
- Experience:Zopiclone hppd?
- Experience:~150mg MDA(oral) - a case of mistaken identity
See also
- Responsible use
- Subjective effects index
- Anxiety
- Psychedelics - Subjective effects
- Dissociatives - Subjective effects
- Deliriants - Subjective effects
External links
References
- ↑ Anxiolysis definition | https://medical-dictionary.thefreedictionary.com/Anxiolysis
- ↑ Medications for Anxiety, Panic and Phobias (PsychCentral) | https://psychcentral.com/lib/medications-for-anxiety-panic-and-phobias/
- ↑ Anxiety medications explained (Psychology Today) | https://www.psychologytoday.com/us/blog/anxiety-help/201111/anti-anxiety-medications-explained
- ↑ The role of GABA in anxiety disorders (ncbi) | https://www.ncbi.nlm.nih.gov/pubmed/12662130
- ↑ Anxiety disorders and GABA neurotransmission: a disturbance of modulation (ncbi) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4303399/
- ↑ Use of Benzodiazepines in Anxiety Disorders (The New England Journal of Medicine) | https://www.nejm.org/doi/full/10.1056/NEJM199305133281907
- ↑ Alcohol and Anxiety (healthline) | https://www.healthline.com/health/alcohol-and-anxiety
- ↑ GHB: The First Authentic Antidepressant by Claude Rifat | https://www.biopsychiatry.com/ghb/authentic.html
- ↑ Gabapentin as a Potential Treatment for Anxiety Disorders (The American Journal of Psychiatry) | https://ajp.psychiatryonline.org/doi/full/10.1176/ajp.155.7.992
- ↑ Oral Ketamine for the Rapid Treatment of Depression and Anxiety in Patients Receiving Hospice Care | https://www.liebertpub.com/doi/abs/10.1089/jpm.2010.9808