Diarylethylamines

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The general structure for a diarylethylamine

Diarylethylamines are an individual class of dissociatives, which differ in their chemical structure from others like PCP or ketamine, but typically produce similar, sometimes unique effects. They are very novel and are research chemicals, which can be bought online.

Pharmacology

NMDAR binding affinities for five target 1,2-diphenylethylamines and reference compounds

Compound	IC50 ± SEM (nM)	Ki ± SEM (nM)
PCP	91 ± 1.3	57.9 ± 0.8
Ketamine	508.5 ± 30.1	323.9 ± 19.2
Memantine	594.2 ± 41.3	378.4 ± 26.3
(+)-MK-801	4.1 ± 1.6	2.5 ± 1.0
DPH (Diphenidine)	28.6 ± 3.5	18.2 ± 2.2
2-MXP (Methoxphenidine)	56.5 ± 5.8	36.0 ± 3.7
3-MXP	30.3 ± 2.6	19.3 ± 1.7
4-MXP	723.8 ± 69.9	461.0 ± 44.5
2-Cl-DPH	14.6 ± 2.1	9.3 ± 1.3
NMDAR binding affinites determined using [3H]-(+)-MK-801 in rat forebrain.

Examples

• Diphenidine
• Ephenidine
• Methoxphenidine (MXP)

See also

• Responsible use
• Dissociative
• Arylcyclohexylamine