GHB

GHB, also known as γ-Hydroxybutyric acid and 4-hydroxybutanoic acid, is a naturally occurring substance found in the human central nervous system, as well as in wine, beef, small citrus fruits, and in small amounts in almost all animals.[1] It is also categorized as an illegal drug in many countries.[2]

GHB as the sodium salt, known as sodium oxybate (INN) or by the trade name Xyrem,[3] is used to treat cataplexy[4] and excessive daytime sleepiness in patients with narcolepsy. It has also been used in a medical setting as a general anesthetic, to treat conditions such as insomnia, clinical depression, narcolepsy, and alcoholism, and to improve athletic performance.[5] It is also used as an intoxicant (illegally in many jurisdictions) or as a date rape drug.[6]

GHB is naturally produced in the human body's cells and is structurally related to the ketone body beta-hydroxybutyrate. As a supplement or drug, it is used most commonly in the form of a salt. GHB is also produced as a result of fermentation, and so is found in small quantities in some beers and wines. Succinic semialdehyde dehydrogenase deficiency is a disease that causes GHB to accumulate in the blood.