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'''2,5-Dimethoxy-4-ethylphenethylamine''' (also known as '''2C-E''', or colloquially as '''"Aquarust"'''<ref name="pubchemSYN">https://pubchem.ncbi.nlm.nih.gov/compound/2C-E#section=Synonyms</ref> and '''"Eternity"'''<ref name="pubchemSYN" />) is a potent synthetic [[psychoactive class::psychedelic]] of the [[chemical class::phenethylamine]] chemical class. It produces a highly dose-sensitive array of [[psychedelic]] effects comparable to those produced [[mescaline]] or other potent members of the [[2C-x]] family when [[Route of administration|administered]].
'''2,5-Dimethoxy-4-ethylphenethylamine''' (commonly known as '''2C-E''', or colloquially as '''"Aquarust"'''<ref name="pubchemSYN">https://pubchem.ncbi.nlm.nih.gov/compound/2C-E#section=Synonyms</ref> and '''"Eternity"'''<ref name="pubchemSYN" />) is a [[psychoactive class::psychedelic]] substance of the [[chemical class::phenethylamine]] chemical class that produces psychedelic effects when [[Route of administration|administered]]. It is a member of the [[2C-x family]] of psychedelic phenethylamines, all of which were derived from the systematic modification of the [[mescaline]] molecule.
2C-E was first synthesized and tested for human activity by [[Alexander Shulgin]] in 1977.<ref>Shulgin, Alexander. "Pharmacology Lab Notes #2". Lafayette, CA. (1976-1980). p236 (Erowid.org) | https://erowid.org/library/books_online/shulgin_labbooks/shulgin_labbook2_searchable.pdf</ref> and was documented in his 1991 book [[PiHKAL]] ("Phenethylamines I Have Known and Loved"). It was rated as a member of the so-called "magical half-dozen" which refers to Shulgin's self-rated most important [[phenethylamine]]-derived compounds, all of which except [[mescaline]] he developed and synthesized himself. They are found within the first book of [[PiHKAL]], and are as follows: [[Mescaline]], [[DOM]], [[2C-B]], 2C-E, [[2C-T-2]] and [[2C-T-7]]. 2C-E began to appear in drug seizures around 2004<ref>"2,5-Dimethoxy-4-Ethylphenethylamine (2C-E) encountered in Ft. Pierce, Florida and Royal Oak, Michigan". Microgram Bulletin. Drug Enforcement Agency. Nov 2004. 37(11):p193-194 (Erowid.org) | https://erowid.org/library/periodicals/microgram/microgram_2004-11.pdf</ref>.
2C-E was first synthesized and tested for human activity by [[Alexander Shulgin]] in 1977<ref>Shulgin, Alexander. "Pharmacology Lab Notes #2". Lafayette, CA. (1976-1980). p236 (Erowid.org) | https://erowid.org/library/books_online/shulgin_labbooks/shulgin_labbook2_searchable.pdf</ref> and documented in his 1991 book [[PiHKAL]] ("Phenethylamines I Have Known and Loved").<ref name="pihkal2CE">Shulgin, A., & Shulgin, A. (1991).
[http://isomerdesign.com/PiHKAL/read.php?id=24 Read #24 2C-E | PiHKAL  · info]. Retrieved Jan 22, 2018.</ref> It is rated as a member of the so-called "magical half-dozen" which refers to Shulgin's self-rated most important [[phenethylamine]]-derived compounds, all of which except [[mescaline]] he developed and synthesized himself. They are found within the first book of [[PiHKAL]], and are as follows: [[Mescaline]], [[DOM]], [[2C-B]], 2C-E, [[2C-T-2]] and [[2C-T-7]]. The general body of anecdotal reports tend to characterize 2C-E as a highly unpredictable, [[dose response curve|dose-sensitive]] psychedelic notorious for its strong visuals and significant "body load".
Overall, anecdotal reports tend to characterize 2C-E as a highly unpredictable, dose-sensitive psychedelic known for its strong visuals and intense "body load". The majority of reports on the effects produced by this substance indicate that it is likely overly challenging for those who are not already extensively experienced with [[hallucinogens]], particularly potent psychedelics. Therefore it is highly advised to approach this very powerful, dose-sensitive [[hallucinogenic]] substance with the proper amount of precaution, preparation, and [[harm reduction practices]] if one chooses to use it.
2C-E began to appear in drug seizures around 2004.<ref>"2,5-Dimethoxy-4-Ethylphenethylamine (2C-E) encountered in Ft. Pierce, Florida and Royal Oak, Michigan". Microgram Bulletin. Drug Enforcement Agency. Nov 2004. 37(11):p193-194 (Erowid.org) | https://erowid.org/library/periodicals/microgram/microgram_2004-11.pdf</ref> While primarily distributed online as a [[research chemical]], it is also sometimes distributed on the street as 'mescaline' or 'synthetic mescaline'. Psychedelic users are advised to note the economic non-viability of retailing [[mescaline]], which lacks the material potency and profit margins to distribute in pill or gel-cap form.
Very little data exists about the pharmacological properties, metabolism, and toxicity of 2C-E, and it has a limited history of human use. Today, it is used for both [[recreational drug use|recreational]] and [[entheogen|entheogenic]] purposes. Many reports indicate that the safe use of this substance may be overly difficult for those who are not already experienced with [[hallucinogens]]. It is highly advised to approach this very powerful, dose-sensitive [[hallucinogenic]] substance with the proper amount of precaution and [[harm reduction practices]] if choosing to use it.
==History and culture==
{{HistoryStub}}
==Chemistry==
==Chemistry==
2C-E or 2,5-dimethoxy-4-ethylphenethylamine is a substituted [[phenethylamines|phenethylamine]] featuring a phenyl ring bound to an amino (NH<sub>2</sub>) group through an ethyl chain. 2C-E contains methoxy functional groups CH<sub>3</sub>O- attached to carbons R<sub>2</sub> and R<sub>5</sub> and an ethyl chain bound to carbon R<sub>4</sub> of the phenyl ring. 2C-E belongs to the 2C family of phenethylamines which contain methoxy groups on the 2 and 5 positions of the benzene ring.<ref>http://isomerdesign.com/PiHKAL/read.php?id=24</ref>
2C-E or 2,5-dimethoxy-4-ethylphenethylamine is a substituted [[phenethylamines|phenethylamine]] featuring a phenyl ring bound to an amino (NH<sub>2</sub>) group through an ethyl chain. 2C-E contains methoxy functional groups CH<sub>3</sub>O- attached to carbons R<sub>2</sub> and R<sub>5</sub> and an ethyl chain bound to carbon R<sub>4</sub> of the phenyl ring. 2C-E belongs to the 2C family of phenethylamines which contain methoxy groups on the 2 and 5 positions of the benzene ring.<ref>http://isomerdesign.com/PiHKAL/read.php?id=24</ref>
==Pharmacology==
==Pharmacology==
{{pharmacology}}
{{Further|Serotonergic psychedelic}}
{{Further|Serotonergic psychedelic}}
2C-E's [[psychedelic]] effects are believed to come from its efficacy at the [[Serotonin#The 5-HT system|5-HT<sub>2A</sub> receptor]] as a [[Agonist#Agonists|partial agonist]]. However, the role of these interactions and how they result in the [[psychedelic]] experience continues to remain elusive.
2C-E's [[psychedelic]] effects are believed to come from its efficacy at the [[Serotonin#The 5-HT system|5-HT<sub>2A</sub> receptor]] as a [[Agonist#Agonists|partial agonist]]. However, the role of these interactions and how they result in the [[psychedelic]] experience remains the subject of ongoing scientific investigation.
==Subjective effects==
==Subjective effects==
{{Preamble/SubjectiveEffects}}
{{Preamble/SubjectiveEffects}}
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|{{effects/physical|
|{{effects/physical|
*'''[[Effect::Stimulation]]''' - In terms of its effects on the physical energy levels of the user, 2C-E is usually considered to be very energetic and stimulating in a fashion that is quite comparable to that of [[MDMA]] although it is encouraged instead of forced.
*'''[[Effect::Stimulation]]''' - In terms of its effects on the physical energy levels of the user, 2C-E is usually considered to be very energetic and stimulating in a fashion that is comparable to that of [[MDMA]], although it is 'encouraged' instead of 'forced'.
*'''[[Effect::Spontaneous physical sensations]]''' - The "body high" of 2C-E is manifested as one of the most proportionally intense in comparison to almost all of the classical psychedelics. The sensation itself can be described as an intense and slightly uncomfortable energetic pins and needles sensation that constantly encompasses a person's entire body. It is usually felt over every square inch of the skin but occasionally manifests itself in the form of a continuously shifting, tingling sensation that travels up and down the body in spontaneous waves. Alongside this, many users report uncomfortable body feelings characterized by dysphoric aches and urges to shift the position of one's body and prolonged tensing of unusual combinations of muscle groups.
*'''[[Effect::Spontaneous physical sensations]]''' - The "body high" of 2C-E is manifested as one of the most proportionally intense in comparison to almost all of the classical psychedelics. The sensation itself can be described as an intense and slightly uncomfortable energetic pins and needles sensation that constantly encompasses a person's entire body. It is usually felt over the surface of the skin but occasionally manifests itself in the form of a continuously shifting, tingling sensation that travels up and down the body in intermittent waves. Alongside this, many users report uncomfortable body feelings characterized by dysphoric aches and urges to shift the position of one's body and prolonged tensing of unusual combinations of muscle groups.
**'''[[Effect::Physical euphoria]]''' - Feelings of frequent but unpredictable rushes of warm physical euphoria are extremely common and very pleasurable. These move from the top of the head downwards before enveloping one's whole body.
**'''[[Effect::Physical euphoria]]''' - Feelings of frequent but unpredictable rushes of warm physical euphoria are extremely common and very pleasurable. These move from the top of the head downwards before enveloping one's whole body.
*'''[[Effect::Tactile enhancement]]'''
*'''[[Effect::Tactile enhancement]]'''
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*'''[[Effect::Increased blood pressure]]'''
*'''[[Effect::Increased blood pressure]]'''
*'''[[Effect::Increased perspiration]]'''
*'''[[Effect::Increased perspiration]]'''
*'''[[Effect::Nausea]]''' - Mild to extreme nausea is consistently reported when consumed in moderate to high doses and either passes once the tripper has vomited or gradually fades by itself as the peak sets in.
*'''[[Effect::Nausea]]''' - Mild to extreme nausea is consistently reported when consumed in moderate to high doses and either passes once the user has vomited or gradually fades by itself as the peak sets in.
*'''[[Effect::Dehydration]]'''
*'''[[Effect::Dehydration]]'''
*'''[[Effect::Frequent urination]]'''
*'''[[Effect::Frequent urination]]'''
*'''[[Effect::Pupil dilation]]'''
*'''[[Effect::Pupil dilation]]'''
*'''[[Effect::Teeth grinding]]''' - This component can be considered to be less intense when compared with that of entactogenic stimulants like [[MDMA]].
*'''[[Effect::Teeth grinding]]''' - This component can be considered to be less intense when compared with that of entactogenic stimulants like [[MDMA]].
*'''[[Effect::Seizure]]''' - This is a rarely observed effect but is thought to be able to happen in those predisposed to them, especially while in physically taxing conditions such as being dehydrated, fatigued, undernourished, or overheated.{{citation needed}}
*'''[[Effect::Seizure]]''' - This is a rarely observed effect but is believed to be a risk in those predisposed to them, especially while in physically taxing conditions such as being dehydrated, fatigued, undernourished, or overheated.{{citation needed}}
}}
}}
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==Toxicity and harm potential==
==Toxicity and harm potential==
{{further|Research chemicals#Toxicity and harm potential|Responsible use #Hallucinogens}}
{{further|Research chemicals#Toxicity and harm potential|Responsible use #Hallucinogens}}
The toxicity and long-term health effects of recreational 2C-E use do not seem to have been studied in any scientific context and the exact [[Toxicity::toxic dose is unknown]]. This is because 2C-E is a [[research chemical]] with very little history of human usage. Anecdotal evidence from those within the community who have tried 2C-E suggests that there are no negative health effects attributed to simply trying the substance by itself at low to moderate doses and using it very sparingly (but nothing can be completely guaranteed). [https://www.google.com/ Independent research] should always be done to ensure that a combination of two or more substances is safe before consumption.
The toxicity and long-term health effects of recreational 2C-E use do not seem to have been studied in any scientific context and the exact [[Toxicity::toxic dose is unknown]]. This is because 2C-E is a [[research chemical]] with a limited history of human usage.
It is strongly recommended that one use [[responsible drug use|harm reduction practices]], such as [[volumetric dosing]], when using this substance to ensure the administration of the intended dose.
Anecdotal reports from those who have tried this compound suggest that there are no negative health effects attributed to simply trying the substance by itself at low to moderate doses and using it very sparingly (although nothing can be completely guaranteed). [https://www.google.com/ Independent research] should always be conducted to ensure that a combination of two or more substances is safe before consumption.
It is strongly recommended that one use [[responsible drug use|harm reduction practices]], such as [[volumetric dosing]], when using this substance so as to ensure the accurate administration of the intended dose.
===Tolerance and addiction potential===
===Tolerance and addiction potential===
2C-E is [[Addiction potential::not habit-forming]] and the desire to use it can actually decrease with use. It is most often self-regulating.
Although no formal studies have been conducted, it is not unreasonable to assume that like psychedelics in general, 2C-E is [[Addiction potential::not habit-forming]] and that the desire to use it can actually decrease with use.
Tolerance to the effects of 2C-E are built [[Time to full tolerance::almost immediately after ingestion]]. After that, it takes about [[Time to half tolerance::5-7 days]] for the tolerance to be reduced to half and [[Time to zero tolerance::7-10 days]] to be back at baseline (in the absence of further consumption). 2C-E presents cross-tolerance with [[Cross-tolerance::all [[psychedelic]]s]], meaning that after the consumption of 2C-E all psychedelics will have a reduced effect.
Tolerance to the effects of 2C-E are built [[Time to full tolerance::almost immediately after ingestion]]. After that, it takes about [[Time to half tolerance::5-7 days]] for the tolerance to be reduced to half and [[Time to zero tolerance::7-10 days]] to be back at baseline (in the absence of further consumption). 2C-E presents cross-tolerance with [[Cross-tolerance::all [[psychedelic]]s]], meaning that after the consumption of 2C-E all psychedelics will have a reduced effect.
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===Dangerous interactions===
===Dangerous interactions===
{{DangerousInteractions}}
{{DangerousInteractions}}
{{DangerousInteractions/Intro}}
Although many substances are safe on their own, they can become dangerous and even life-threatening when combined with other substances. The list below contains some common potentially dangerous combinations, but may not include all of them. Certain combinations may be relatively harmless in low doses of each but can still increase the risk of unpredictable injury or death. [https://www.google.com/ Independent research] should always be done to ensure that a combination of two or more substances is safe before consumption.
*'''[[Tramadol]]''' - Tramadol lowers the seizure threshold<ref>Talaie, H., Panahandeh, R., Fayaznouri, M. R., Asadi, Z., & Abdollahi, M. (2009). Dose-independent occurrence of seizure with tramadol. Journal of medical toxicology, 5(2), 63-67. doi:10.1007/BF03161089</ref> and [[psychedelics]] may act as triggers for seizures, particularly in those who are predisposed to them.{{citation needed}}
*'''[[Tramadol]]''' - Tramadol lowers the seizure threshold<ref>Talaie, H., Panahandeh, R., Fayaznouri, M. R., Asadi, Z., & Abdollahi, M. (2009). Dose-independent occurrence of seizure with tramadol. Journal of medical toxicology, 5(2), 63-67. doi:10.1007/BF03161089</ref> and [[psychedelics]] may act as triggers for seizures, particularly in those who are predisposed to them.{{citation needed}}
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*'''[https://en.wikipedia.org/wiki/Lithium_(medication) Lithium]''' - Lithium is often used as treatment for bipolar disorder. It may possibly cause elevated risk of seizures and psychosis due to its [[Glutamate|glutaminergic]] and [[GABA|GABAergic]] effects.{{citation needed}}
*'''[https://en.wikipedia.org/wiki/Lithium_(medication) Lithium]''' - Lithium is often used as treatment for bipolar disorder. It may possibly cause elevated risk of seizures and psychosis due to its [[Glutamate|glutaminergic]] and [[GABA|GABAergic]] effects.{{citation needed}}
==Legality==
==Legal status==
*'''Brazil''' - Possession, production and sale is illegal as it is listed on Portaria SVS/MS nº 344.<ref>http://portal.anvisa.gov.br/documents/10181/3115436/%281%29RDC_130_2016_.pdf/fc7ea407-3ff5-4fc1-bcfe-2f37504d28b7</ref>
*'''Brazil''' - Possession, production and sale is illegal as it is listed on Portaria SVS/MS nº 344.<ref>http://portal.anvisa.gov.br/documents/10181/3115436/%281%29RDC_130_2016_.pdf/fc7ea407-3ff5-4fc1-bcfe-2f37504d28b7</ref>
*'''Denmark:''' 2C-E is a Schedule I drug. {{citation needed}}
*'''Denmark:''' 2C-E is a Schedule I drug. {{citation needed}}
WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section.
DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.
2,5-Dimethoxy-4-ethylphenethylamine (commonly known as 2C-E, or colloquially as "Aquarust"[1] and "Eternity"[1]) is a psychedelic substance of the phenethylamine chemical class that produces psychedelic effects when administered. It is a member of the 2C-x family of psychedelic phenethylamines, all of which were derived from the systematic modification of the mescaline molecule.
2C-E was first synthesized and tested for human activity by Alexander Shulgin in 1977[2] and documented in his 1991 book PiHKAL ("Phenethylamines I Have Known and Loved").[3] It is rated as a member of the so-called "magical half-dozen" which refers to Shulgin's self-rated most important phenethylamine-derived compounds, all of which except mescaline he developed and synthesized himself. They are found within the first book of PiHKAL, and are as follows: Mescaline, DOM, 2C-B, 2C-E, 2C-T-2 and 2C-T-7. The general body of anecdotal reports tend to characterize 2C-E as a highly unpredictable, dose-sensitive psychedelic notorious for its strong visuals and significant "body load".
2C-E began to appear in drug seizures around 2004.[4] While primarily distributed online as a research chemical, it is also sometimes distributed on the street as 'mescaline' or 'synthetic mescaline'. Psychedelic users are advised to note the economic non-viability of retailing mescaline, which lacks the material potency and profit margins to distribute in pill or gel-cap form.
Very little data exists about the pharmacological properties, metabolism, and toxicity of 2C-E, and it has a limited history of human use. Today, it is used for both recreational and entheogenic purposes. Many reports indicate that the safe use of this substance may be overly difficult for those who are not already experienced with hallucinogens. It is highly advised to approach this very powerful, dose-sensitive hallucinogenic substance with the proper amount of precaution and harm reduction practices if choosing to use it.
2C-E or 2,5-dimethoxy-4-ethylphenethylamine is a substituted phenethylamine featuring a phenyl ring bound to an amino (NH2) group through an ethyl chain. 2C-E contains methoxy functional groups CH3O- attached to carbons R2 and R5 and an ethyl chain bound to carbon R4 of the phenyl ring. 2C-E belongs to the 2C family of phenethylamines which contain methoxy groups on the 2 and 5 positions of the benzene ring.[5]
2C-E's psychedelic effects are believed to come from its efficacy at the 5-HT2A receptor as a partial agonist. However, the role of these interactions and how they result in the psychedelic experience remains the subject of ongoing scientific investigation.
Subjective effects
Disclaimer: The effects listed below cite the Subjective Effect Index (SEI), an open research literature based on anecdotal user reports and the personal analyses of PsychonautWikicontributors. As a result, they should be viewed with a healthy degree of skepticism.
It is also worth noting that these effects will not necessarily occur in a predictable or reliable manner, although higher doses are more liable to induce the full spectrum of effects. Likewise, adverse effects become increasingly likely with higher doses and may include addiction, severe injury, or death ☠.
Physical effects
Stimulation - In terms of its effects on the physical energy levels of the user, 2C-E is usually considered to be very energetic and stimulating in a fashion that is comparable to that of MDMA, although it is 'encouraged' instead of 'forced'.
Spontaneous physical sensations - The "body high" of 2C-E is manifested as one of the most proportionally intense in comparison to almost all of the classical psychedelics. The sensation itself can be described as an intense and slightly uncomfortable energetic pins and needles sensation that constantly encompasses a person's entire body. It is usually felt over the surface of the skin but occasionally manifests itself in the form of a continuously shifting, tingling sensation that travels up and down the body in intermittent waves. Alongside this, many users report uncomfortable body feelings characterized by dysphoric aches and urges to shift the position of one's body and prolonged tensing of unusual combinations of muscle groups.
Physical euphoria - Feelings of frequent but unpredictable rushes of warm physical euphoria are extremely common and very pleasurable. These move from the top of the head downwards before enveloping one's whole body.
Nausea - Mild to extreme nausea is consistently reported when consumed in moderate to high doses and either passes once the user has vomited or gradually fades by itself as the peak sets in.
Teeth grinding - This component can be considered to be less intense when compared with that of entactogenic stimulants like MDMA.
Seizure - This is a rarely observed effect but is believed to be a risk in those predisposed to them, especially while in physically taxing conditions such as being dehydrated, fatigued, undernourished, or overheated.[citation needed]
Drifting(melting, flowing, breathing and morphing) - In comparison to other psychedelics, this effect can be described as highly detailed, slow and smooth in motion, static in appearance and unrealistic/cartoon-like in style.
The visual geometry that is produced by this substance can be comprehensively described as structured in their organization, organic in geometric style, intricate in complexity, large in size, fast and smooth in motion, colorful in scheme, glossy in color, sharp in their edges and equally rounded and angular in their corners. It gives off a contradictory natural and synthetic feel that at higher dosages are significantly more likely to result in states of Level 8B visual geometry over Level 8A.
Hallucinatory states
2C-E produces a full range of high-level hallucinatory states in a fashion that is more consistent and reproducible than that of many other commonly used psychedelics. This particularly holds true in comparison to other substances within the family of psychedelic phenethylamines. These effects include:
Internal hallucinations (settings, sceneries, and landscapes; alterations in perspective and scenarios and plots) - In comparison to other psychedelics such as LSD, 2C-E is extremely reliable at producing hallucinations embedded within visual geometry. This particular effect commonly contains hallucinations with scenarios, settings, and concepts. They are more likely to present themselves within dark environments and can be described as internal in their manifestation, lucid in believability, interactive in style and almost exclusively of a personal, religious, spiritual, science-fiction, fantasy, surreal, nonsensical or transcendental nature in their overall theme.
Cognitive effects
The head space of 2C-E is described by many as one which is both insightful and relatively unaltered in its thought processes even at moderate to high dosages.
Analysis enhancement - This component is introspection dominant and consistently manifested only in the context of a non-social setting in which the user is alone.
Empathy, affection, and sociability enhancement - This component is consistently manifested only in the context of social settings in which one is within the company of others. These feelings are a little weaker and less sharp than those produced by substances such as MDMA and 2C-B but still often prove strong enough to provide long-lasting therapeutic effects.
Synaesthesia - In its fullest manifestation, this is a very rare and non-reproducible effect. Increasing the dosage can increase the likelihood of this occurring, but seems to only be a prominent part of the experience among those who are already predisposed to synaesthetic states. However, many reports indicate that this substance is relatively reliable at inducing synaesthetic states in those who are predisposed to them.[citation needed]
Cannabis - When used in combination with cannabis, both the visual and cognitive effects of 2C-E can be intensified and extended with extreme efficiency. This should be used with extreme caution if one is not experienced with psychedelics as this can also amplify the anxiety, confusion and psychosis producing aspects of cannabis significantly.
Dissociatives - When used in combination with dissociatives, the geometry, euphoria, dissociation and hallucinatory effects are often greatly enhanced. Dissociative-induced holes, spaces, and voids while under the influence of LSD have significantly more vivid visuals than dissociatives alone present, and more intense internal hallucinations, and corresponding confusion which can spontaneously manifest as delusions and psychosis.
MDMA - When used in conjunction with MDMA, the physical and cognitive effects of MDMA are amplified. The visual, physical and cognitive effects of 2C-E are also intensified with an overwhelming euphoric pleasure manifested through uniquely pleasurable body highs and headspaces, and uniquely colorful and awe-inspiring visuals. The synergy between these substances is unpredictable, and it is best to start with markedly lower dosages than one would take for both substances individually. Additionally, users should be aware that there are reasons to believe that this combination may result in unforeseen neurotoxic effects, so a strong sense of caution and independent research are highly advised if one decides to experiment with this combination.[citation needed]
Alcohol - This interaction is not typically recommended due to alcohol’s ability to cause dehydration, nausea and physical fatigue which can negatively affect a trip if taken in moderate to high dosages. This combination is, however, typically considered to be safe in low doses and can often "take the edge off" a trip as well as dull its psychedelic effects in a fashion somewhat similar to benzodiazepines, albeit in a more physically distressing manner.
Benzodiazepines - When used in combination with benzodiazepines, benzodiazepines can, depending on the dosage, slightly to completely reduce the intensity of the cognitive, physical and visual effects of an LSD trip. They are very efficient at stopping "bad trips" at the cost of amnesia and reduced trip intensity. Caution is advised when acquiring them for this purpose due to the very high addiction potential that benzodiazepines possess.
Psychedelics - When used in combination with other psychedelics, each substance's physical, cognitive and visual effects intensify and synergize strongly. The synergy between these substances is unpredictable, and for this reason generally not advised. If choosing to combine psychedelics, it is recommended to start with significantly lower dosages than one would take for either substance individually.
The toxicity and long-term health effects of recreational 2C-E use do not seem to have been studied in any scientific context and the exact toxic dose is unknown. This is because 2C-E is a research chemical with a limited history of human usage.
Anecdotal reports from those who have tried this compound suggest that there are no negative health effects attributed to simply trying the substance by itself at low to moderate doses and using it very sparingly (although nothing can be completely guaranteed). Independent research should always be conducted to ensure that a combination of two or more substances is safe before consumption.
It is strongly recommended that one use harm reduction practices, such as volumetric dosing, when using this substance so as to ensure the accurate administration of the intended dose.
Tolerance and addiction potential
Although no formal studies have been conducted, it is not unreasonable to assume that like psychedelics in general, 2C-E is not habit-forming and that the desire to use it can actually decrease with use.
Tolerance to the effects of 2C-E are built almost immediately after ingestion. After that, it takes about 5-7 days for the tolerance to be reduced to half and 7-10 days to be back at baseline (in the absence of further consumption). 2C-E presents cross-tolerance with [[Cross-tolerance::all psychedelics]], meaning that after the consumption of 2C-E all psychedelics will have a reduced effect.
Warning:Many psychoactive substances that are reasonably safe to use on their own can suddenly become dangerous and even life-threatening when combined with certain other substances. The following list provides some known dangerous interactions (although it is not guaranteed to include all of them).
Always conduct independent research (e.g. Google, DuckDuckGo, PubMed) to ensure that a combination of two or more substances is safe to consume. Some of the listed interactions have been sourced from TripSit.
Tramadol - Tramadol lowers the seizure threshold[6] and psychedelics may act as triggers for seizures, particularly in those who are predisposed to them.[citation needed]
Stimulants - Stimulants affect many parts of the brain. Combined with psychedelics, stimulation can turn into uncontrollable anxiety, panic, thought loops and paranoia. This interaction may cause elevated risk of psychosis.[citation needed]
Lithium - Lithium is often used as treatment for bipolar disorder. It may possibly cause elevated risk of seizures and psychosis due to its glutaminergic and GABAergic effects.[citation needed]
Legal status
Brazil - Possession, production and sale is illegal as it is listed on Portaria SVS/MS nº 344.[7]
↑Talaie, H., Panahandeh, R., Fayaznouri, M. R., Asadi, Z., & Abdollahi, M. (2009). Dose-independent occurrence of seizure with tramadol. Journal of medical toxicology, 5(2), 63-67. doi:10.1007/BF03161089
↑Noteikumi par Latvijā kontrolējamajām narkotiskajām vielām, psihotropajām vielām un prekursoriem (2,5-Dimetoksifeniletānamīni) | http://likumi.lv/doc.php?id=121086
↑China Food and Drug Administration. (2017, April 10). 关于印发《非药用类麻醉药品和精神药品列管办法. Retrieved from http://www.buzzle.com
