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LSA, also known as Ergine, d-lysergic acid amide and d-lysergamide, is a naturally occurring psychedelic alkaloid of the lysergamide family that occurs in many plants such as Morning glory seeds, Hawaiian Baby Woodrose seeds and some species of fungi.
LSA was assayed for human activity by Albert Hofmann in self-trials in 1947 (well before it was known to be a natural compound). Intramuscular administration of a 500 microgram dose led to a tired, dreamy state with an inability to maintain clear thoughts. After a short period of sleep, the effects were gone and normal baseline was recovered within five hours.[1] This suggests that the theory of LSA being the main psychedelic compound within morning glory seeds and Hawaiian baby woodrose is debatable as anecdotal reports suggest that the effects of synthetic LSA and iso-LSA are only slightly psychedelic in their effects and may well be triggered by a mixture of various lysergamides instead of one specific compound.
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N,N-Dimethyltryptamine (DMT or N,N-DMT) is a psychedelic compound of the tryptamine family. When ingested, DMT acts as an intense hallucinogenic drug.[2] Its presence is known to be widespread throughout the plant kingdom.[3][4] DMT is a close relative of the psychedelic drugs 5-HO-DMT and 5-MeO-DMT. Although various theories have been formulated, the compound's biological function has yet to be determined.
DMT results in powerful visuals and intense psychedelic mental effects when smoked, injected, snorted, or taken orally (with an MAOI such as Harmaline). When smoked, DMT is a powerful visionary psychedelic that produces short acting effects. When taken in combination with an MAOI or RIMA, it becomes orally active. DMT is present in over 65 species of plants. It has been used traditionally in South America in ayahuasca brews since at least around the year 1500 and archaeological evidence suggests its use in snuffs (such as yopo, cohoba, or parica) since 2080 BCE.[5]
Depending on dose and method of administration, the effects of DMT can range from mild psychedelic states to powerfully immersive life-changing experiences-- the nature of which are often described as being the ultimate displacement from normal consciousness where users are placed in a subjective state in which they encounter ineffable spiritual/alien realms and alternate realities.
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Psilocin (also known as 4-HO-DMT, psilocine, psilocyn, or psilotsin) is a substituted tryptamine alkaloid and a serotonergic psychedelic drug. It is present in most psychedelic mushrooms together with its phosphorylated counterpart psilocybin (the pro-drug for psilocin). The mind-altering effects of psilocin are highly variable and subjective, resembling those of LSD and DMT. Psilocin is the active component in psilocybin mushrooms where psilocybin is dephosphorylated into the active psilocin.
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α-Methyltryptamine (αMT, AMT, Indopan), is a psychedelic, stimulant, and entactogen drug of the tryptamine class.[6] It was originally developed as an antidepressant by workers at a Michigan pharmaceutical manufacturing company known as Upjohn in the 1960s.[7] This drug may be overly intense in its physical effects for those who are not already experienced with psychedelics.
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5-MeO-MIPT, or 5-methoxy-N-methyl-N-isopropyltryptamine also known as Moxy is a psychedelic and entactogenic drug in a class of compounds commonly known as tryptamines, and is the N-methyl-N-isopropyl homologue of the psychedelic 5-MeO-DMT. It has structural and pharmacodynamic properties similar to the drugs 5-MeO-DiPT, DiPT, and MiPT.
5-MeO-MIPT has no history of human usage prior to the 1985 publication of its synthesis and pharmacology in the Journal of Medicinal Chemistry by Repke, Grotjahn & Shulgin. In modern times it is used as a recreational drug and an entheogen, rarely sold on the streets and almost exclusively obtained as a grey area research chemical through the use of online vendors.
Chemistry
Pharmacology
LSA acts as a 5-HT1A, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT5 and 5-HT6 partial agonist; the psychedelic effects are believed to come from LSA's efficacy at the 5-HT2A receptors.[8] There is also efficacy at all dopamine receptors and all adrenoreceptors. [9]
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DMT acts as a 5-HT2A, 5-HT2C and 5-HT1A partial agonist; the psychedelic effects are believed to come from DMT's efficacy at the 5-HT2A receptors. There is also some affinity at dopamine D1, α1-adrenergic, α2-adrenergic receptors.
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Psilocin is the pharmacologically active chemical and metabolite of psilocybin, and is found in the body after ingestion of psilocybin, either on its own or in psychedelic mushrooms. It acts as a 5-HT2A, 5-HT2C and 5-HT1A partial agonist; the psychedelic effects are believed to come from psilocin's efficacy at the 5-HT2A receptors. At high doses, there is some efficacy to noradrenaline receptors.
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AMT acts as a releasing agent of serotonin, noradrenaline, and dopamine[10] as well as a non-selective serotonin receptor agonist.[11] It acts as a very weak, non-selective RIMA in-vitro[12] and in-vivo.[13], but this is unlikely to be very significant if at all with typical doses.
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The mechanism that produces the hallucinogenic and entactogenic effects of 5-MeO-MiPT is thought to result primarily from 5-HT2A receptor agonism, although additional mechanisms of action such as inhibition of MAO may be involved also.[14][15]
Subjective effects
The physical effects of LSA can be broken down into five components all of which progressively intensify proportional to dosage. These are described below and generally include:
- Spontaneous tactile sensations - the body high of LSA can be described as a mild yet pleasurable, soft tingling sensation. This is largely noticed in high doses and is accompanied by strong waves of physical euphoria which are usually manifested spontaneously at different unpredictable points throughout the trip but can also maintain a consistent presence, in either case however they steadily rise with the onset and hit their limit once the peak has been reached.
- Sedation - in terms of its effects on the physical energy levels of the tripper, LSA tends to be sedating however it can be setting dependent. For example, when taken in settings with large amounts of stimulus or during physically strenuous activities such as walking, running, climbing or dancing it is fully capable of becoming stimulating and energetic. In contrast however, when taken in calm environments such as darkened rooms with comfortable seating it is consistently relaxing, peaceful and quite sedating.
- Vasoconstriction
The head space of LSA is described by many as extremely relaxing yet lucid and clear headed in its style when compared to other commonly used psychedelics such as LSD or Psilocin. Although it is primarily sedating, it is accompanied by fast paced bursts of thought.
LSA contains a large number of psychedelic cognitive effects. The most prominent of these typical effects include:
- Connectivity of thought
- Introspection
- Acceleration of thought
- Enhancement of current mind state
- Feelings of fascination, importance and awe
- Conceptual thinking
- Ego suppression, loss and death
- Time distortion
- Direct communication with the subconscious
- Deja-Vu
The visual effects of LSA are mostly present when large doses have been consumed and proportionally mild in comparison to the intensity of its accompanying cognitive and physical effects when compared to substances such as LSD and psilocin.
LSA presents a full and complete array of potential visual enhancements which generally includes:
As for visual distortions and alterations,these are significantly more simplistic from that of open eye distortions found with other psychedelics. Effects experienced are detailed below:
- Drifting (Melting, Flowing, Breathing and morphing) - in comparison to other psychedelics this effect can be described as mild but highly detailed yet cartoon like in appearance. They are fast yet smooth in motion and fleeting in their permanence. This is an inconsistently manifested effect with some never reporting such effects.
- Colour shifting
The visual geometry that is present throughout this trip can be described as more similar in appearance to that of 4-AcO-DMT, Ayahuasca and 2C-E than LSD or 2C-B. They can be comprehensively described as structured in their organization, organic in geometric style, intricate in complexity, zoomed out and small in size, fast and smooth in motion, colourful in scheme, glossy in colour, blurred in their edges and rounded in their corners. They have a much more "natural" feel to them than LSD and at higher dosages are significantly more likely to result in states of Level 7B visual geometry over Level 7A.
LSA produces a full range of high level hallucinatory states in a fashion that is very consistent when taken in large doses. The effects of such states include,
- External hallucinations - these are extremely common within LSA and partially follow the content of the users current thought process.
- Internal hallucinations - unlike LSD, LSA consistently produces moderate to high level hallucinatory states in high doses. This particular effect can be compared to a lucid dream state and commonly contains hallucinations with plots, settings, autonomous entity contact and scenarios. They are more common within dark environments and can be described as internal in their manifestation, lucid in believability, interactive in style and almost exclusively religious, spiritual, mystical or transcendental nature in their overall theme. These hallucinations are complemented by a powerful enhancement of the ability to visualize concepts. This ability eventually becomes so drawn out proportional to dosage that it leads to full blown hallucinatory states that are entirely lucid and for the most part controllable.
The auditory effects of LSA are common in their occurrence and exhibit a full range of effects which commonly includes:
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Subjective effects
The physical effects of LSA can be broken down into five components all of which progressively intensify proportional to dosage. These are described below and generally include:
- Spontaneous tactile sensations - the body high of LSA can be described as a mild yet pleasurable, soft tingling sensation. This is largely noticed in high doses and is accompanied by strong waves of physical euphoria which are usually manifested spontaneously at different unpredictable points throughout the trip but can also maintain a consistent presence, in either case however they steadily rise with the onset and hit their limit once the peak has been reached.
- Sedation - in terms of its effects on the physical energy levels of the tripper, LSA tends to be sedating however it can be setting dependent. For example, when taken in settings with large amounts of stimulus or during physically strenuous activities such as walking, running, climbing or dancing it is fully capable of becoming stimulating and energetic. In contrast however, when taken in calm environments such as darkened rooms with comfortable seating it is consistently relaxing, peaceful and quite sedating.
- Vasoconstriction
The head space of LSA is described by many as extremely relaxing yet lucid and clear headed in its style when compared to other commonly used psychedelics such as LSD or Psilocin. Although it is primarily sedating, it is accompanied by fast paced bursts of thought.
LSA contains a large number of psychedelic cognitive effects. The most prominent of these typical effects include:
- Connectivity of thought
- Introspection
- Acceleration of thought
- Enhancement of current mind state
- Feelings of fascination, importance and awe
- Conceptual thinking
- Ego suppression, loss and death
- Time distortion
- Direct communication with the subconscious
- Deja-Vu
The visual effects of LSA are mostly present when large doses have been consumed and proportionally mild in comparison to the intensity of its accompanying cognitive and physical effects when compared to substances such as LSD and psilocin.
LSA presents a full and complete array of potential visual enhancements which generally includes:
As for visual distortions and alterations,these are significantly more simplistic from that of open eye distortions found with other psychedelics. Effects experienced are detailed below:
- Drifting (Melting, Flowing, Breathing and morphing) - in comparison to other psychedelics this effect can be described as mild but highly detailed yet cartoon like in appearance. They are fast yet smooth in motion and fleeting in their permanence. This is an inconsistently manifested effect with some never reporting such effects.
- Colour shifting
The visual geometry that is present throughout this trip can be described as more similar in appearance to that of 4-AcO-DMT, Ayahuasca and 2C-E than LSD or 2C-B. They can be comprehensively described as structured in their organization, organic in geometric style, intricate in complexity, zoomed out and small in size, fast and smooth in motion, colourful in scheme, glossy in colour, blurred in their edges and rounded in their corners. They have a much more "natural" feel to them than LSD and at higher dosages are significantly more likely to result in states of Level 7B visual geometry over Level 7A.
LSA produces a full range of high level hallucinatory states in a fashion that is very consistent when taken in large doses. The effects of such states include,
- External hallucinations - these are extremely common within LSA and partially follow the content of the users current thought process.
- Internal hallucinations - unlike LSD, LSA consistently produces moderate to high level hallucinatory states in high doses. This particular effect can be compared to a lucid dream state and commonly contains hallucinations with plots, settings, autonomous entity contact and scenarios. They are more common within dark environments and can be described as internal in their manifestation, lucid in believability, interactive in style and almost exclusively religious, spiritual, mystical or transcendental nature in their overall theme. These hallucinations are complemented by a powerful enhancement of the ability to visualize concepts. This ability eventually becomes so drawn out proportional to dosage that it leads to full blown hallucinatory states that are entirely lucid and for the most part controllable.
The auditory effects of LSA are common in their occurrence and exhibit a full range of effects which commonly includes:
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Subjective effects
The physical effects of DMT can be broken down into two components both of which progressively intensify proportional to dosage. These are described below and generally include:
- Spontaneous tactile sensations - the body high of DMT can be described as a pleasurable, warm, soft, and all encompassing glow. It maintains a consistent presence that quickly rises with the onset and hits its limit once the peak has been reached. It is capable of becoming very powerful at higher doses and remains for up to half an hour after the trip itself.
- Changes in gravity - at higher dosages physical feelings of being catapulted across vast distances at incredibly high speeds are common.
The head space of DMT is described by most as extremely sober and clear headed in its style when compared to other commonly used psychedelics such as LSD, psilocin or even ayahuasca. It contains a limited amount of typical cognitive effects.
The most prominent of these typical effects generally include:
- Enhancement of current mind state
- Removal of cultural filter
- Feelings of fascination, importance and awe
- Rejuvination
- Direct communication with the subconscious
- Ego suppression, loss and death
- States of unity and interconnectedness
DMT in its smokeable form is perhaps the least psychologically intoxicating psychedelic. It is due to this lack of mental intoxication that many people describe DMT not as something which feels not like a drug induced trip but a genuine experience that is actually happening to them. It's worth noting that many people report that DMT contains less personal insight in comparison to orally active psychedelics such as ayahuasca, LSD and psilocin due to its short acting nature.
Ayahuasca presents a full and complete array of possible visual enhancements which generally include:
As for visual distortions and alterations, effects experienced are detailed below:
- Drifting (Melting, Breathing, Morphing and Flowing) - in comparison to other psychedelics this effect can be described as highly detailed, slow and smooth in motion and static in their appearance.
- Tracers
- After images
- Texture repetition
- Colour shifting
- Scenery slicing
The visual geometry that is present throughout this trip can be described as more similar in appearance to that of Psilocin than LSD. They can be comprehensively described as structured in their organization, organic in geometric style, intricate in complexity, large in size, fast and smooth in motion, colourful in scheme, glossy in colour, equal in blurred and sharp edges and equal in rounded and angular corners. At higher dosages they are significantly more likely to result in states of Level 7B visual geometry over Level 7A.
The geometry present with smokeable DMT is often considered to be the most profoundly intricate and complex set of visual geometry found within the entirety of the psychedelic experience. In comparison to orally active DMT (ayahuasca) they are significantly more digital in appearance and contain a colour scheme which is similar to LSD but a structured style that is closer to high dose Psilocin.
DMT produces a full range of high level hallucinatory states in a fashion that is more consistent and reproducible than that of any other commonly used psychedelic. These effects include:
- External hallucinations
- Internal hallucinations - this particular effect commonly contains hallucinations with scenarios, settings, concepts and autonomous entity contact. They are more common within dark environments and can be described as internal in their manifestation, lucid in believability, interactive in style and almost exclusively religious, spiritual, mystical or transcendental nature in their overall theme.
The auditory effects of DMT are common in their occurrence and exhibit a full range of effects which commonly include:
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Subjective effects
The physical effects of Psilocin can be broken down into two components all of which progressively intensify proportional to dosage. These are described below and generally include:
- Spontaneous tactile sensations - the body high of psilocin can be described as a pleasurable, warm, soft and all encompassing tingling sensation. This maintains a consistent presence that steadily rises with the onset and hits its limit once the peak has been reached.
- Sedation - in terms of its effects on the physical energy levels of the tripper psilocin is considered by most to be relaxing, stoning and mildly sedating. This sense of sedation is accompanied by compulsive yawning, a runny nose and watering eyes.
The head space of psilocin is described by many as extremely relaxing, profound and stoning in its style when compared to other commonly used psychedelics such as LSD or 2C-B which tend to be energetic and stimulating. It contains a large number of psychedelic typical and unique cognitive effects.
The most prominent of these typical effects generally include:
- Enhancement of current mind state
- Connectivity of thought
- Feelings of fascination, importance and awe
- Time distortion
- Outrospection
- Deja-Vu
- Removal of cultural filter
- Feelings of predeterminism
- Conceptual thinking
- Direct communication with the subconsious
- Ego suppression, loss and death
- Feelings of interdependent opposites
- Delusions
- States of unity and interconnectedness
- Enhancement and suppression cycles - this can be described as constant waves of extremely stimulated and profound thinking which are spontaneously surpassed in a cyclic fashion by waves of general thought suppression and mental intoxication. These two states seem to switch between each other in a consistent loop once every 20 - 60 minutes.
Psilocin presents a full and complete array of possible visual enhancements which generally includes:
As for visual distortions and alterations, effects experienced are detailed below:
- Drifting (Melting, Flowing, Breathing and morphing) - in comparison to other psychedelics this effect can be described as highly detailed, realistic, slow and smooth in motion and static in their appearance.
- Tracers
- After images
- Texture repetition
- Colour shifting
- Scenery slicing
The visual geometry that is present throughout this trip can be described as more similar in appearance to that of 4-AcO-DMT, Ayahuasca and 2C-E than LSD. They can be comprehensively described as structured in their organization, organic in geometric style, intricate in complexity, large in size, fast and smooth in motion, colourful in scheme, glossy in colour, blurred in their edges and rounded in their corners. They have a very "natural" feel to them and at higher dosages are significantly more likely to result in states of Level 7B visual geometry over Level 7A.
Psilocin and its various other forms produce a full range of high level hallucinatory states in a fashion that is more consistent and reproducible than that of many other commonly used psychedelics. These effects generally include:
- External hallucinations
- Internal hallucinations - this particular effect commonly contains hallucinations with scenarios, landscapes, settings, concepts and autonomous entity contact. They are more common within dark environments and can be described as internal in their manifestation, lucid in believability, interactive in style and almost exclusively of religious, spiritual, mystical or a transcendental nature in their overall theme.
The auditory effects of psilocin are common in their occurrence and exhibit a full range of effects which commonly includes:
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Subjective effects
The physical effects of AMT can be broken down into five components all of which progressively intensify proportional to dosage. These are described below and generally include:
- Spontaneous tactile sensations - AMT's body high can be described as an intense and constant all encompassing sensation. In comparison to other psychedelics, this sensation does not manifest itself in the form of a continuously shifting tingling sensation that travels up and down the body spontaneously, instead being felt as an extended unchanging activation of every nerve ending on the body that lasts throughout the entire duration of the trip. This everlasting droning is immensely pleasurable but can become overwhelmingly intense and almost a burden at higher levels
- Stimulation - in terms of its effects on the physical energy levels of the tripper AMT is very stimulating, resulting in jaw clenching and a shakiness and unsteadiness of the hands but encouraging trippers to move around, run, dance, climb and generally engage in physical activities. In comparison, other more commonly used psychedelics such as psilocybin are generally sedating and relaxed.
- Nausea - in terms of the physical discomfort experienced on this substance, moderate to extreme nausea is almost consistently reported when consumed at any dosage. This either passes once the tripper has vomited or gradually fades by itself as the peak sets in.
- Difficulty urinating - a slight difficulty urinating is occasionally present.
- Head aches - many people report head aches towards the end of the experience
- Loss of temperature regulation
In comparison to more traditional psychedelics such as LSD, DMT and Psilocin the AMT head space is described as not nearly as deep, insightful or profound.
The total sum of these cognitive components regardless of the setting generally includes:
- Introspection - this component is consistently manifested only in the context of a non social setting in which the user is alone.
- Acceleration of thought
- Connectivity of thought
- Increased empathy, love and sociability
- Enhancement of current mind state
- Euphoria
- Conceptual thinking
- Ego suppression, loss and death
- Time distortion
- Increased empathy, love and sociability - this component is consistently manifested only in the context of social settings in which one is within the company of others. These feelings of sociability, love and empathy are a little weaker and less sharp than those found on substances such as MDMA and 2C-B but still prove strong enough to provide long lasting therapeutic effects.
AMT presents a full and complete array of possible visual enhancements which generally includes:
As for visual distortions and alterations, effects experienced are detailed below:
- Drifting (Melting, Flowing, Breathing and morphing) - in comparison to other psychedelics this effect can be described as highly detailed, slow and smooth in motion, static in their appearance and unrealistic/ cartoon like in style.
- Tracers
- After images
- Texture repetition - in comparison to more commonly used psychedelics such as LSD and psilocin this effect is significantly less intricate and complex although still very distinct in its presence.
- Colour shifting
- Scenery slicing
The visual geometry that is present throughout this trip can be described as more similar in appearance to that of Psilocin, and 2C-E than LSD. At lower levels they appear to be bland and simplistic but become equal in terms of intricacy and depth to that of any of the classical psychedelics. They can be comprehensively described as structured in their organization, organic in geometric style, intricate in complexity, large in size, fast and smooth in motion, colourful in scheme, glossy in colour, blurred in their edges and rounded in their corners. They have a "natural" feel to them and at higher dosages are significantly more likely to result in states of Level 7B visual geometry over Level 7A.
At high dosages AMT can produce a full range of high level hallucinatory states in a fashion that is more consistent and reproducible than that of many other commonly used psychedelic. These effects include:
- External hallucinations
- Internal hallucinations - this particular effect commonly contains hallucinations with scenarios, settings, concepts and autonomous entity contact. They are more common within dark environments and can be described as internal in their manifestation, lucid in believability, interactive in style and almost exclusively of religious, spiritual, mystical or a transcendental nature in their overall theme.
The auditory effects of AMT are common in their occurrence and exhibit a full range of effects which commonly includes,
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Subjective effects
Differences in methods of consumption
This substance can be taken via oral ingestion or it can be smoked. When ingested orally the experience puts more of an emphasis on visual effects but can be broken up into two stages, the first half of the trip feels stimulating and entactogenic and the second half feelsmore similar to a traditional typtamine psychedelic.
If smoked however these stages of experience are not present and the experience places more of an emphasis on physically and cognitively stimulating effects accompanied by subtle and mild changes in visual perception.
The physical effects of 5-MeO-MIPT can be broken down into three components all of which progressively intensify proportional to dosage. These are described below and generally include:
- Spontaneous tactile sensations - the body high of 5-MeO-MIPT can be described as a pleasurable, warm, soft and all encompassing glow. There is also a cold, sharp tingling sensation that is manifested spontaneously at different unpredictable points throughout the trip but for others it can maintain a consistent presence that steadily rises with the onset and hits its limit once the peak has been reached.
- Stimulation and Sedation - in terms of its effects on the physical energy levels of the tripper, 5-MeO-MIPT can be both sedating and stimulating. The physical energy levels seem to manifest themselves in waves in an unpredictable pattern. This seems to be partially setting dependant and during physically strenuous situations such as running or dancing it can become stimulating and energetic. In contrast however, in calm environments such as darkened rooms with comfortable seating it can become relaxing, peaceful and even moderately sedating.
- Nausea - as the tripper begins to come up, nausea is not uncommon and can sometimes result in initial vomiting, but passes once this over or the trip begins to fully set in. In comparison to other psychedelics such as psilocin, LSD, and 2C-E, this could actually be very considered very mild in its intensity. In comparison to 5-MeO-DIPT, this substance has a much lower tendency to trigger unpleasant physical reactions and has been described as much less physically stimulating.
The head space of 5-MeO-MIPT is described by many as one which is both insightful and moderately relaxing, but at some points quite stimulating. This substance produces a large number of general psychedelic cognitive effects. The most prominent of these effects generally include:
- Introspection - this component is consistently manifested only in the context of a non social setting in which the user is alone.
- Increased empathy, love and sociability - this component is consistently manifested only in the context of social settings in which one is within the company of others. These feelings of sociability, love and empathy are a little weaker and less sharp than those found on substances such as MDMA and 2C-B but still prove strong enough to provide long lasting therapeutic effects.
- Acceleration of thought
- Connectivity of thought
- Time distortion
- Feelings of fascination, importance and awe
- Conceptual thinking
- Enhancement of current mind state
- Removal of cultural filter
- Ego suppression, loss and death
5-MeO-MIPT presents a complete array of possible visual enhancements which generally includes:
As for visual distortions and alterations, these generally include:
- Drifting (Melting, Breathing, Warping and Flowing) - in comparison to other psychedelics this effect can be described as highly detailed, slow and smooth in motion and static in appearance.
- Tracers
- After images
- Texture repetition
- Colour shifting
- Scenery slicing
The visual geometry that is present throughout this trip can be described as more similar in appearance to that of Psilocin, 4-AcO-DMT or Ayahuasca than that of LSD or 2C-B. They can be comprehensively described as structured in their organization, organic in geometric style, intricate in complexity, large in size, fast and smooth in motion, colourful in scheme, glossy in colour, equal in blurred and sharp edges and equal in rounded and angular corners. At higher dosages they are significantly more likely to result in states of level 7B visual geometry over level 7A.
In terms of their manifestation they are progressive in nature and continuously self complexify in settings with little or no visual input and disturbances. For example, darkness will cause the geometry to progressively intensify but this can immediately be reset back down to base level by simply turning on a bright light or actively performing a physical task which requires any level of concentration.
5-MeO-MIPT produces a full range of high level hallucinatory states in a fashion that is more consistent and reproducible than that of many other commonly used psychedelics.
These effects generally include:
- External hallucinations
- Internal hallucinations - in comparison to other psychedelics such as LSD, 5-MeO-MIPT is extremely high in hallucinations embedded within visual geometry. This particular effect commonly contains hallucinations with with scenarios, settings, concepts and autonomous entity contact. They are more common within dark environments and can be described as internal in their manifestation, lucid in believability, interactive in style and almost exclusively of religious, spiritual, mystical or a transcendental nature in their overall theme.
The auditory effects of 5-MeO-MIPT are common in their occurrence and exhibit a full range of effects which commonly includes:
Toxicity and Harm Potential
Vasoconstriction
LSA should not be used nonstop. When used repeatedly over a short period of time the vasoconstriction effects build up while the psychoactive effects get weaker. If you’re feeling sore legs, this is a sign of the vasoconstriction effects building up in your body.[16] The legs feel sore because not enough blood is getting to the muscles. The upper leg muscles are the largest, most energy consuming muscles in the body, and they will feel sore if blood flow to them is lowered even slightly. If you’ve taken HBWR seeds, morning glory seeds or pure LSA and are experiencing sore legs a well needed break is completely necessary. With LSA it can take up to 3 days of abstinence to get back to vasoconstriction baseline. [17]
Lethal Dosage
The LD50 of LSA for human beings has never been reached in any setting, but is thought to be incredibly high, similar to LSD. There are not any known deaths associated directly with pharmacological causes of LSA, but rather due to self-harm, impaired judgement, and drug interactions. One known case involves suicide after ingestion of Morning Glory seeds.[18] Another instance is a death due to falling off of a building after ingestion of Hawaiian Baby Woodrose seeds and ethanol as well as the subsequent usage of cannabis.[19]
Tolerance and Addiction Potential
LSA tolerance lasts for approximately a week, meaning that it is very difficult to form an addiction to this substance.
Natural plant sources
Morning glory seeds

The seeds of many species of morning glory contain lysergamide alkaloids such as the psychedelic known as LSA.[20] Though the chemical LSA is not legal in some countries, the seeds are found in many gardening stores; however, it's worth noting that the seeds from commercial sources are often coated in some form of pesticide or methylmercury which can result in extreme nausea if ingested. Seeds without these pesticides can be purchased cheaply online and are freely available through search engines such as Google.
When using morning glory seeds the dosage for oral consumption is generally considered to be,
- Light : 50 - 100 seeds / 1.5 - 3 g
- Common : 100 - 250 seeds / 3 - 6 g
- Strong : 250 - 400 seeds / 6 - 10 g
- Heavy : 400 + seeds / 10 + g
Hawaiian baby woodrose seeds

Hawaiian baby woodrose is a perennial climbing vine that is native to the Indian subcontinent and introduced to numerous areas worldwide, including Hawaii, Africa and the Caribbean. Hawaiian Baby Woodrose seeds may be consumed for their various lysergamide alkaloids, such as LSA.[21] Although the chemical LSA is not legal in some countries, the seeds are found in many gardening stores; however, the seeds from commercial sources are often coated in some form of pesticide or methylmercury which can result in extreme nausea if ingested. Seeds without these pesticides can be purchased cheaply online and are freely available through search engines such as Google.
When using Hawaiian Baby Woodrose seeds the dosage for oral consumption is generally considered to be,
- Threshold : 1 - 4 seeds
- Light : 3 - 6 seeds
- Common : 5 - 8 seeds
- Strong : 7 - 12 seeds
- Heavy : 12 + seeds
Legal issues
- Australia: Consumption, sale and possession of LSA is illegal.
- The Netherlands: Consumption, sale and possession of LSA is illegal.
- New Zealand: Consumption, sale and possession of LSA is illegal. The plants and seeds of morning glory species are legal to possess, cultivate, buy, and distribute.
- Sweden: Consumption, sale and possession of LSA is illegal.
- United Kingdom: LSA is a Class A drug, categorised as a precursor to LSD.
- United states: As a precursor to LSD, LSA is a DEA schedule III drug
See Also
References
- ↑ #26. LSD-25 (LA-111, ergine, d-lysergamide) - TIHKAL | http://www.erowid.org/library/books_online/tihkal/tihkal26.shtml
- ↑ HELL AND BACK - National Geographic Adventure | http://www.kirasalak.com/Peru.html
- ↑ Ott, Jonathan (1994). Ayahuasca Analogues: Pangæan Entheogens (1st ed.). Kennewick, WA, USA: Natural Products. pp. 81–3. | http://www.worldcat.org/title/ayahuasca-analogues-pangan-entheogens/oclc/32895480
- ↑ Shulgin, Alexander; Shulgin, Ann (1997). "DMT is Everywhere". (page 277) TiHKAL: The Continuation (1st ed.) | http://www.worldcat.org/title/tihkal-the-continuation/oclc/38503252
- ↑ Erowid - DMT Basics | http://www.erowid.org/chemicals/dmt/dmt_basics.shtml
- ↑ Erowid Online Books : TIHKAL - #48 a-MT | http://www.erowid.org/library/books_online/tihkal/tihkal48.shtml
- ↑ US Patent 3296072 - Method of Treating Mental Depression
- ↑ COMPARATIVE STUDY ON THE SEROTONIN ANTAGONISM OF AMIDE DERIVATIVES OF LYSERGIC ACID AND OF ERGOT ALKALOIDS | http://jpet.aspetjournals.org/content/122/1/124.short
- ↑ http://molpharm.aspetjournals.org/content/12/4/631.short
- ↑ The effects of non-medically used psychoactive drugs on monoamine neurotransmission in rat brain | http://linkinghub.elsevier.com/retrieve/pii/S0014-2999(06)01381-1
- ↑ In vitro screening of psychoactive drugs by [(35)S]GTPgammaS binding in rat brain membranes | https://www.jstage.jst.go.jp/article/bpb/30/12/30_12_2328/_article
- ↑ Studies of Monoamine Oxidase and Semicarbazide-Sensitive Amine Oxidase II. Inhibition by α-Methylated Substrate-Analogue Monoamines, α-Methyltryptamine, α-Methylbenzylamine and Two Enantiomers of α-Methylbenzylamine | https://www.jstage.jst.go.jp/article/jphs1951/41/2/41_2_191/_article
- ↑ THE EFFECT OF THREE TRYPTAMINE DERIVATIVES ON SEROTONIN METABOLISM IN VITRO AND IN VIVO | http://jpet.aspetjournals.org/content/127/2/110.short
- ↑ Psychotomimetic N-methyl-N-isopropyltryptamines. Effects of variation of aromatic oxygen substituents | http://pubs.acs.org/doi/abs/10.1021/jm00145a007
- ↑ The effects of non-medically used psychoactive drugs on monoamine neurotransmission in rat brain | http://www.sciencedirect.com/science/article/pii/S0014299906013811
- ↑ http://www.ncbi.nlm.nih.gov/pubmed/11128853
- ↑ http://animalsci.highwire.org/content/84/11/3167.short
- ↑ SUICIDE FOLLOWING MORNING GLORY SEED INGESTION | http://ajp.psychiatryonline.org/article.aspx?articleID=149522
- ↑ Two cases of lysergamide intoxication by ingestion of seeds from Hawaiian Baby Woodrose | http://www.fsijournal.org/article/PIIS0379073809004745
- ↑ http://jama.jamanetwork.com/article.aspx?articleid=1165951
- ↑ http://www.sciencedirect.com/science/article/pii/S0379073809004745