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WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section.
DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.
4-Hydroxy-diisopropyltryptamine (commonly known as 4-HO-DiPT and sometimes referred to as Iprocin) is a synthetic psychedelic substance of the tryptamine chemical class that produces modified psilocin-like effects when administered.
Following the publication of the synthesis of 4-HO-DiPT by a team led by David Repke in 1977[1], Alexander Shulgin researched its effects, describing one experience with the substance as being "like a religious awakening".[2] 4-HO-DiPT is described in his 1997 book TiHKAL (Tryptamines I Have Known and Loved). It is the 4-hydroxyl analog of DiPT.[3]
Today it is either used recreationally or as an entheogenic compound and is typically acquired through the use of online research chemical vendors. It remains relatively uncommon even for a substituted tryptamine and has very little history of human usage.
4-HO-DiPT, or 4-Hydroxy-N,N-diisopropyltryptamine, is a synthetic indole alkaloid molecule of the tryptamine chemical class. Tryptamines share a core structure comprised of a bicyclic indole heterocycle attached at R3 to an amino group via an ethyl side chain. 4-HO-DiPT is substituted at R4 of its indole heterocycle with a hydroxyl functional group OH−. It also contains two isopropyl groups bound to the terminal amine RN of its tryptamine backbone. 4-HO-DiPT is a 4-hydroxy analog of DiPT and the N-substituted isopropyl homolog of 4-HO-DMT.
Like with most psychedelic tryptamines, 4-HO-DiPT is thought to act principally as a 5-HT2Apartial agonist. The psychedelic effects are believed to come from 4-HO-DiPT's binding efficacy at the 5-HT2A receptors. However, the role of these interactions and how they result in the psychedelic experience continues to remain elusive.
Disclaimer: The effects listed below cite the Subjective Effect Index (SEI), an open research literature based on anecdotal user reports and the personal analyses of PsychonautWikicontributors. As a result, they should be viewed with a healthy degree of skepticism.
It is also worth noting that these effects will not necessarily occur in a predictable or reliable manner, although higher doses are more liable to induce the full spectrum of effects. Likewise, adverse effects become increasingly likely with higher doses and may include addiction, severe injury, or death ☠.
There are currently no anecdotal reports which describe the effects of this compound within our experience index. Additional experience reports can be found here:
The toxicity and long-term health effects of recreational 4-HO-DiPT use do not seem to have been studied in any scientific context and the exact toxic dose is unknown. This is because 4-HO-DiPT is a research chemical with very little history of human usage. Anecdotal evidence from people within the psychonaut community who have tried 4-HO-DiPT suggests that there are no negative health effects attributed to simply trying the drug by itself at low to moderate doses and using it very sparingly (but nothing can be completely guaranteed). Independent research should always be done to ensure that a combination of two or more substances is safe before consumption.
4-HO-DiPT is not habit-forming and the desire to use it can actually decrease with regular consumption. Like with most psychedelics, it is most often thought to be self-regulating.
Tolerance to the effects of 4-HO-DiPT are built almost immediately after ingestion. After that, it takes about 3 days for the tolerance to be reduced to half and 7 days to be back at baseline (in the absence of further consumption). 4-HO-DiPT presents cross-tolerance with [[Cross-tolerance::all psychedelics]], meaning that after the consumption of 4-HO-DiPT all psychedelics will have a reduced effect.
Legal issues
Due to its relative obscurity, the possession and sale of 4-HO-DiPT is unscheduled in most countries.
United Kingdom - 4-HO-DiPT is a Class A drug in the United Kingdom as a result of the tryptamine catch-all clause.[4]
Sweden - 4-HO-DiPT is classified as a "health hazard" under the act "Lagen om förbud mot vissa hälsofarliga varor" (translated to the "Act on the Prohibition of Certain Goods Dangerous to Health") as of March 1, 2005 in their regulation SFS 2005:26, making it illegal to sell or possess.[5]
USA - 4-HO-DiPT is unscheduled in the United States. It may be considered an analogue of psilocin (4-HO-DMT), a Schedule I drug under the Controlled Substances Act. As such, the sale for human consumption or the use for illicit non-medical or industrial intents and purposes could be prosecuted as crimes under the Federal Analogue Act.[citation needed]
Florida - "4-Hydroxy-N,N-diisopropyltryptamine" is a Schedule I controlled substance in the state of Florida, making it illegal to buy, sell, or possess.[6]
