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5-Methoxy-N,N-Diisopropyltryptamine (also known as 5-MeO-DiPT, Foxy, and Foxy Methoxy) is a psychedelic substance of the tryptamine chemical class. It is structurally analogous to 5-MeO-MiPT, DiPT and mexamine (desacetylmelatonin). The first human trials of 5-MeO-DiPT were undertaken by Alexander Shulgin in 1975.[1] Shulgin co-authored and published a paper detailing the synthesis and human psycho-pharmacology of the drug in 1981.[2] A summary of the synthesis and reports of human use is included in Shulgin's 1997 book TiHKAL ("Tryptamines I Have Known And Loved").[3]
This compound is orally active, and dosages between 6–20 mg are commonly reported. Many users note an unpleasant body load accompanies higher dosages. 5-MeO-DiPT is also taken by insufflation, or sometimes it is smoked or injected. Some users also report sound distortion, which is also noted with the related drug, DiPT.
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Chemistry
5-MeO-DiPT, or 5-methoxy-N,N-diisopropyltryptamine, is a synthetic indole alkaloid molecule of the tryptamine class. Tryptamines share a core structure comprised of a bicylic indole heterocycle attached at R3 to an amino group via an ethyl side chain. 5-MeO-DiPT is substituted at R5 of its indole heterocycle with a methoxy (MeO) functional group CH3O−; it also contains two isopropyl chains bound to the terminal amine RN of its tryptamine backbone (DiPT).
5-MeO-DiPT is the N-substituted diisopropyl homolog of 5-MeO-MiPT.
5-MeO-DiPT's psychedelic effects are believed to come from its efficacy at the 5-HT2A receptor as a partial agonist, although additional mechanisms of action such as MAOIs may also be involved.[4] However, the role of these interactions and how they result in the psychedelic experience continues to remain elusive.
Disclaimer: The effects listed below cite the Subjective Effect Index (SEI), an open research literature based on anecdotal user reports and the personal analyses of PsychonautWikicontributors. As a result, they should be viewed with a healthy degree of skepticism.
It is also worth noting that these effects will not necessarily occur in a predictable or reliable manner, although higher doses are more liable to induce the full spectrum of effects. Likewise, adverse effects become increasingly likely with higher doses and may include addiction, severe injury, or death ☠.
The toxicity and long-term health effects of recreational 5-MeO-DiPT use do not seem to have been studied in any scientific context and the exact toxic dose is unknown. This is because 5-MeO-DiPT is a research chemical with very little history of human usage. Anecdotal evidence from people within the psychonaut community who have tried 5-MeO-DiPT suggests that there are no negative health effects attributed to simply trying the drug by itself at low to moderate doses and using it very sparingly (but nothing can be completely guaranteed). Independent research should always be done to ensure that a combination of two or more substances is safe before consumption.
Excessive doses have caused nausea, vomiting, agitation, decreased blood pressure, pupil dilation, increased heart rate, and hallucinations in a number of young adults. Rhabdomyolysis and renal failure occurred in one young man and another one died 3–4 hours after an apparent rectal overdose.[5] A 24-year-old man also died of this compound being administered into the colon.
5-MeO-DiPT is not habit-forming and the desire to use it can actually decrease with use. It is most often self-regulating.
Tolerance to the effects of 5-MeO-DiPT builds almost immediately after ingestion. After that, it takes about 3 days for the tolerance to be reduced to half and 7 days to be back at baseline (in the absence of further consumption). 5-MeO-DiPT presents cross-tolerance with [[Cross-tolerance::all psychedelics]], meaning that after the consumption of 5-MeO-DiPT all psychedelics will have a reduced effect.
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United Kingdom - 5-MeO-DiPT is a Class A drug in the UK as it is an ether of the drug 5-HO-DiPT[6], which is a Class A drug as a result of the tryptamine catch-all clause.[7]
U.S. - It is a Schedule 1 controlled substance in the USA.
Brazil - Possession, production and sale is illegal as it is listed on Portaria SVS/MS nº 344.[8]
