Talk:Ketamine: Difference between revisions
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===Medical applications=== | ===Medical applications=== | ||
*Wilkinson, S. T., Ballard, E. D., Bloch, M. H., Mathew, S. J., Murrough, J. W., Feder, A., … Sanacora, G. (2017). The Effect of a Single Dose of Intravenous Ketamine on Suicidal Ideation: A Systematic Review and Individual Participant Data Meta-Analysis. American Journal of Psychiatry. https://doi.org/10.1176/appi.ajp.2017.17040472 | *Wilkinson, S. T., Ballard, E. D., Bloch, M. H., Mathew, S. J., Murrough, J. W., Feder, A., … Sanacora, G. (2017). The Effect of a Single Dose of Intravenous Ketamine on Suicidal Ideation: A Systematic Review and Individual Participant Data Meta-Analysis. American Journal of Psychiatry. https://doi.org/10.1176/appi.ajp.2017.17040472 | ||
==Research== | |||
The intravenous administration of 50 - 100 mg of ketamine can reproduce all of the features which have commonly been associated with NDE's. Intramuscular administration also results in NDE's, but events evolve at a slower pace and are longer lasting (Domino et al., 1965; Rumpf ,1969; Collier, 1972; Siegel,1978, 1980,1981; Stafford, 1977; Lilly, 1978; Grinspoon and Bakalar, 1981; White, 1982; Ghoniem et al., 1985; Sputz, 1989; Jansen, 1989a,b, 1990b, 1993, 1995, 1996).<ref>http://www.near-death.com/experiences/lsd03.html</ref> However, Karl Jansen warns: "If ketamine is taken by a rapid .i.v injection, it can sometimes cause the person to stop breathing for a short time (up to a minute). 2 mg/kg given i.v. as a fast injection produced a significant fall in blood oxygen lasting about 10 minutes. When given slowly (over 1.5 minutes), breathing is well maintained and may even increase slightly. However, the self-injector may then pass out before the injection is complete. Any desire to experiment with i.v. use should be resisted for as long as possible. As noted above, ketamine does not usually suppress breathing, but exceptions occur after rapid i.v. injection. This is safer when the psrson is lying down, or at least not sitting on an edge. Bathrooms are dangerous because the surface are hard and angular, there is a risk of drowing, and bleeding is more likely in warm water."<ref>Ketamine: Dreams and Realities, p276-277</ref> | |||
Revision as of 02:48, 15 October 2017
Potential references
Medical applications
- Wilkinson, S. T., Ballard, E. D., Bloch, M. H., Mathew, S. J., Murrough, J. W., Feder, A., … Sanacora, G. (2017). The Effect of a Single Dose of Intravenous Ketamine on Suicidal Ideation: A Systematic Review and Individual Participant Data Meta-Analysis. American Journal of Psychiatry. https://doi.org/10.1176/appi.ajp.2017.17040472
Research
The intravenous administration of 50 - 100 mg of ketamine can reproduce all of the features which have commonly been associated with NDE's. Intramuscular administration also results in NDE's, but events evolve at a slower pace and are longer lasting (Domino et al., 1965; Rumpf ,1969; Collier, 1972; Siegel,1978, 1980,1981; Stafford, 1977; Lilly, 1978; Grinspoon and Bakalar, 1981; White, 1982; Ghoniem et al., 1985; Sputz, 1989; Jansen, 1989a,b, 1990b, 1993, 1995, 1996).[1] However, Karl Jansen warns: "If ketamine is taken by a rapid .i.v injection, it can sometimes cause the person to stop breathing for a short time (up to a minute). 2 mg/kg given i.v. as a fast injection produced a significant fall in blood oxygen lasting about 10 minutes. When given slowly (over 1.5 minutes), breathing is well maintained and may even increase slightly. However, the self-injector may then pass out before the injection is complete. Any desire to experiment with i.v. use should be resisted for as long as possible. As noted above, ketamine does not usually suppress breathing, but exceptions occur after rapid i.v. injection. This is safer when the psrson is lying down, or at least not sitting on an edge. Bathrooms are dangerous because the surface are hard and angular, there is a risk of drowing, and bleeding is more likely in warm water."[2]
- ↑ http://www.near-death.com/experiences/lsd03.html
- ↑ Ketamine: Dreams and Realities, p276-277