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'''Flumazenil''' (sold as '''Anexate''', '''Romazicon''', and other names) is a benzodiazepine receptor antagonist<ref>Whitwam, J. G., & Amrein, R. (1995). Pharmacology of flumazenil. Acta Anaesthesiologica Scandinavica, 39(s108), 3-14.</ref> that is used medically to, for a short time, reverse benzodiazepine overdose in order to safely give supportive care, such as oxygen, fluids, atropine, and norepinephrine.<ref>Whyte, IM (2004). "Benzodiazepines". Medical toxicology. Philadelphia: Williams & Wilkins. pp. 811–22. ISBN 0-7817-2845-2.</ref> Flumazenil produces wakefulness, anxiogenesis, irritability, and lowers the seizure threshold, the opposite of what benzodiazepines usually do. It is of the benzodiazepine chemical class and is a GABAergic, but acts negatively at benzodiazepine receptors. Because it only acts on | '''Flumazenil''' (sold as '''Anexate''', '''Romazicon''', and other names) is a benzodiazepine receptor antagonist<ref>Whitwam, J. G., & Amrein, R. (1995). Pharmacology of flumazenil. Acta Anaesthesiologica Scandinavica, 39(s108), 3-14.</ref> that is used medically to, for a short time, reverse benzodiazepine overdose in order to safely give supportive care, such as oxygen, fluids, atropine, and norepinephrine.<ref>Whyte, IM (2004). "Benzodiazepines". Medical toxicology. Philadelphia: Williams & Wilkins. pp. 811–22. ISBN 0-7817-2845-2.</ref> Flumazenil produces wakefulness, anxiogenesis, irritability, and lowers the seizure threshold, the opposite of what benzodiazepines usually do. It is of the benzodiazepine chemical class and is a GABAergic, but acts negatively at benzodiazepine receptors. Because it only acts on benzodiazepine receptors, it is not effective for barbiturate, opioid, or alcohol overdose.{{citation needed}} | ||
==References== | ==References== | ||
Revision as of 01:35, 9 October 2017
Flumazenil (sold as Anexate, Romazicon, and other names) is a benzodiazepine receptor antagonist[1] that is used medically to, for a short time, reverse benzodiazepine overdose in order to safely give supportive care, such as oxygen, fluids, atropine, and norepinephrine.[2] Flumazenil produces wakefulness, anxiogenesis, irritability, and lowers the seizure threshold, the opposite of what benzodiazepines usually do. It is of the benzodiazepine chemical class and is a GABAergic, but acts negatively at benzodiazepine receptors. Because it only acts on benzodiazepine receptors, it is not effective for barbiturate, opioid, or alcohol overdose.[citation needed]