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Addiction suppression: Difference between revisions
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>Kenan m Undo revision 107813 by Catharsis: compulsive redosing is a short term effect, addiction supression is a long term effect. While seemingly similar, they are fundamentally different. |
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<onlyinclude>'''Addiction suppression''' can be described as the experience of a total or partial removal of a psychological addiction to a specific substance and the cravings associated with it. This can occur as an effect which lasts long after the compound wears off or it can last only while | <onlyinclude>'''Addiction suppression''' can be described as the experience of a total or partial removal of a psychological addiction to a specific substance and the cravings associated with it. This can occur as an effect which lasts long after the compound wears off or it can last only while the compound is still active. Addiction suppression is a rare component and is most commonly associated with [[psychedelic]]s<ref>Psychedelics: entering a new age of addiction therapy | http://www.pharmaceutical-journal.com/news-and-analysis/features/psychedelics-entering-a-new-age-of-addiction-therapy/20066899.article#fn_link_1</ref>, [[psilocin]]<ref>Pilot Study of the 5-HT2AR Agonist Psilocybin in the Treatment of Tobacco Addiction (PubMed.gov / NCBI) | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4286320/</ref>, [[LSD]]<ref>Lysergic acid diethylamide (LSD) for alcoholism: meta-analysis of randomized controlled trials (PubMed.gov / NCBI) | http://www.ncbi.nlm.nih.gov/pubmed/22406913</ref>, [[ibogaine]]<ref>Mind-altering drug could offer life free of heroin (New Scientist) | https://www.newscientist.com/article/mg21929313-900-mind-altering-drug-could-offer-life-free-of-heroin/</ref> and [[N-acetylcysteine]] (NAC).<ref>Cystine/glutamate exchange regulates metabotropic glutamate receptor presynaptic inhibition of excitatory transmission and vulnerability to cocaine seeking (PubMed.gov / NCBI) | http://www.ncbi.nlm.nih.gov/pubmed/16000629</ref> | ||
In terms of psychedelics, this effect seems to be triggered by a combination of [[analysis enhancement]], [[personal bias suppression]] and general [[introspection]]. However, N-acetylcysteine seems to have a more direct effect that occurs as a result of its action on [[glutamine]]rgic and [[dopamine]]rgic pathways which is thought to reverse brain functions | In terms of psychedelics, this effect seems to be triggered by a combination of [[analysis enhancement]], [[personal bias suppression]] and general [[introspection]]. However, N-acetylcysteine seems to have a more direct effect that occurs as a result of its action on [[glutamine]]rgic and [[dopamine]]rgic pathways which is thought to reverse brain functions that have become disturbed by heavy drug addiction.<ref>Cystine/glutamate exchange regulates metabotropic glutamate receptor presynaptic inhibition of excitatory transmission and vulnerability to cocaine seeking (PubMed.gov / NCBI) | http://www.ncbi.nlm.nih.gov/pubmed/16000629</ref></onlyinclude> | ||
===Psychoactive substances=== | ===Psychoactive substances=== | ||
Compounds within our [[psychoactive substance index]] which may cause this effect include: | Compounds within our [[psychoactive substance index]] which may cause this effect include: | ||
Revision as of 20:46, 3 October 2017
Addiction suppression can be described as the experience of a total or partial removal of a psychological addiction to a specific substance and the cravings associated with it. This can occur as an effect which lasts long after the compound wears off or it can last only while the compound is still active. Addiction suppression is a rare component and is most commonly associated with psychedelics[1], psilocin[2], LSD[3], ibogaine[4] and N-acetylcysteine (NAC).[5]
In terms of psychedelics, this effect seems to be triggered by a combination of analysis enhancement, personal bias suppression and general introspection. However, N-acetylcysteine seems to have a more direct effect that occurs as a result of its action on glutaminergic and dopaminergic pathways which is thought to reverse brain functions that have become disturbed by heavy drug addiction.[6]
Psychoactive substances
Compounds within our psychoactive substance index which may cause this effect include:
- 1cP-LSD
- 3-MeO-PCP
- 5-MeO-DMT
- Ayahuasca
- Baclofen
- Cannabidiol
- Citicoline
- Clonidine
- Ibogaine
- Kava
- Ketamine
- LSD
- N-Acetylcysteine
- Psilocin
- Psilocybin mushrooms
- Theanine
See also
References
- ↑ Psychedelics: entering a new age of addiction therapy | http://www.pharmaceutical-journal.com/news-and-analysis/features/psychedelics-entering-a-new-age-of-addiction-therapy/20066899.article#fn_link_1
- ↑ Pilot Study of the 5-HT2AR Agonist Psilocybin in the Treatment of Tobacco Addiction (PubMed.gov / NCBI) | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4286320/
- ↑ Lysergic acid diethylamide (LSD) for alcoholism: meta-analysis of randomized controlled trials (PubMed.gov / NCBI) | http://www.ncbi.nlm.nih.gov/pubmed/22406913
- ↑ Mind-altering drug could offer life free of heroin (New Scientist) | https://www.newscientist.com/article/mg21929313-900-mind-altering-drug-could-offer-life-free-of-heroin/
- ↑ Cystine/glutamate exchange regulates metabotropic glutamate receptor presynaptic inhibition of excitatory transmission and vulnerability to cocaine seeking (PubMed.gov / NCBI) | http://www.ncbi.nlm.nih.gov/pubmed/16000629
- ↑ Cystine/glutamate exchange regulates metabotropic glutamate receptor presynaptic inhibition of excitatory transmission and vulnerability to cocaine seeking (PubMed.gov / NCBI) | http://www.ncbi.nlm.nih.gov/pubmed/16000629