1P-ETH-LAD

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1P-ETH-LAD
Chemical Nomenclature
Common names	1P-ETH-LAD
Substitutive name	1-propionyl-6-ethyl-6-nor-lysergic acid diethyamide
Systematic name	(6aR,9R)-4-propionyl-N,N-diethyl-7-ethyl-4,6,6a,7,8,9-hexahydroindolo[4,3-fg]quinoline-9-carboxamide
Class Membership
Psychoactive class	Psychedelic
Chemical class	Lysergamide
Routes of Administration
WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section. ⇣ Oral Dosage Threshold 25 µg Light 30 - 60 µg Common 60 - 100 µg Strong 100 - 200 µg Heavy 200 µg + Duration Total 6 - 12 hours Onset 30 - 90 minutes Peak 2 - 4 hours Offset 2 - 4 hours After effects 6 - 24 hours DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.
Interactions

Summary sheet: 1P-ETH-LAD

1-Propionyl-6-ethyl-6-nor-lysergic acid diethyamide (also known as 1P-ETH-LAD) is a semisynthetic psychedelic substance of the lysergamide chemical class. It is a designer drug analog and suspected prodrug to ETH-LAD, which shares a close structural relationship with LSD. Anecdotal reports suggest that this compound produces largely similar psychedelic effects comprable to AL-LAD or ETH-LAD.

Like its parent compound ETH-LAD, this compound has been reported to be moderately to significantly more potent than LSD itself. It has also been reported as being subtly different in effect to LSD and is often described as being more visual and synaesthetic, with a deeper, less emotionally-charged headspace analogous to that of psychedelics like 2C-E or DPT. It has also been reported to be more likely to induce undesirable effects like anxiety, thought loops in addition to pronounced nausea and other discomforting physical effects it displays relative to other lysergamides.

Very little data exists about the pharmacological properties, metabolism, and toxicity of 1P-ETH-LAD, and it has little history of human usage before January 2016. It has recently become commonly marketed alongside other designer psychedelics such as 1P-LSD and LSZ as a legal alternative to LSD and is commercially distributed through online research chemical vendors. Due to its high potency, sensitive dose-response, many reports also indicate that the effects of this substance may be overly intense for those who are not already very experienced with hallucinogens. Therefore it is highly advised to approach this unusually potent, long-lasting, and unpredictable hallucinogenic substance with the proper amount of precaution and harm reduction practices if one chooses to use it.

Chemistry

Generic structure of a lysergamide

1P-ETH-LAD, or 1-propionyl-6-ethyl-6-nor-lysergic acid diethylamide, is a semi-synthetic alkaloid of the lysergamide family. 1P-ETH-LAD is a structural analog of lysergic acid, with an N, N-diethylamide functional group bound to R_N of the chemical structure. This core polycyclic structure is an ergoline derivative and has tryptamine and phenethylamine groups embedded within it.

1P-ETH-LAD's structure contains a bicyclic hexahydro indole fused to a bicyclic quinoline group (nor-lysergic acid). 1P-ETH-LAD does not contain a methyl group substituted at R₆ of its nor-lysergic acid skeleton; the nor- prefix represents this. Instead, 1P-ETH-LAD is substituted at R₆ with an ethyl group and at R₁ with a propionyl group. At carbon 8 of the quinoline, an N, N-diethyl carboxamide is bound.

1P-ETH-LAD is a chiral compound with two stereocenters at R₅ and R₈. 1P-ETH-LAD, also called (+)-D-1P-ETH-LAD, has an absolute configuration of (5R, 8R). The three other stereoisomers of 1P-ETH-LAD have not been shown to possess psychoactive properties.

Pharmacology

Further information: Serotonergic psychedelic

This compound likely acts as a 5-HT_2A partial agonist. The psychedelic effects are believed to come from 1P-ETH-LAD's efficacy at the 5-HT_2A receptors. However, the role of these interactions and how they result in the psychedelic experience continues to remain elusive.

1P-ETH-LAD shares many common traits with its parent compound LSD; it appears to be roughly equal in potency as well as similar in mechanism although the progression and duration of effects are compressed (while remaining qualitatively less intense and more manageable) due to suspected differences in how it is metabolized. Research has shown formation of ETH-LAD from 1P-ETH-LAD incubated in human serum, suggesting that it functions as a pro-drug.

Subjective effects

Disclaimer: The effects listed below cite the Subjective Effect Index (SEI), an open research literature based on anecdotal user reports and the personal analyses of PsychonautWiki contributors. As a result, they should be viewed with a healthy degree of skepticism.

It is also worth noting that these effects will not necessarily occur in a predictable or reliable manner, although higher doses are more liable to induce the full spectrum of effects. Likewise, adverse effects become increasingly likely with higher doses and may include addiction, severe injury, or death ☠. While the subjective effects are almost identical to that of LSD, 1P-ETH-LAD is significantly shorter in its duration and less uncomfortable in both its negative physical side effects and generalized anxiety.

Physical effects

• Spontaneous physical sensations - The "body high" of 1P-ETH-LAD can be described as proportionally intense in comparison to its accompanying visual and cognitive effects. It behaves as a euphoric, fast-moving, sharp and location specific tingling sensation. For some, it is manifested spontaneously at different, unpredictable points throughout the trip, but for most, it maintains a steady presence that rises with the onset and hits its limit once the peak has been reached. In comparison to LSD, it is a little less sharp in its tingles, less likely to be uncomfortable but otherwise essentially identical.
• Stimulation - Concerning its effects on the physical energy levels of the tripper, 1P-ETH-LAD is usually considered to be very energetic and stimulating without being forced. For example, when taken in any environment it will usually encourage physical activities such as running, walking, climbing or dancing. In comparison, other more commonly used psychedelics such as psilocin are sedating and relaxing.
• Bodily control enhancement
• Increased heart rate
• Nausea - Mild nausea is occasionally reported when consumed in moderate to high dosages and either passes instantly once the tripper has vomited or gradually fades by itself as the peak sets in.
• Pupil dilation
• Tactile enhancement - Feelings of enhanced tactile sensation are consistently present at moderate levels throughout most 1P-ETH-LAD trips.
• Teeth grinding
• Temperature regulation suppression

Cognitive effects

In comparison to other psychedelics such as psilocin, LSA and ayahuasca, 1P-ETH-LAD is significantly more stimulating and fast-paced regarding the specific style of thought stream which it produces and contains a large number of potential effects associated with both psychedelic tryptamines and phenethylamines. In comparison to LSD, it is often reported to be less anxiety-provoking and more emotionally comfortable and forgiving.

The most prominent of these cognitive effects generally include:

• Analysis enhancement
• Conceptual thinking
• Delusions
• Déjà vu
• Emotionality enhancement
• Perception of interdependent opposites
• Immersion enhancement
• Increased music appreciation
• Laughter
• Memory suppression
  • Ego death
• Motivation enhancement
• Novelty enhancement
• Personal bias suppression
• Thought acceleration
• Thought loops
• Time distortion
• Unity and interconnectedness
• Wakefulness

Visual effects

Enhancements

• Colour enhancement
• Pattern recognition enhancement
• Visual acuity enhancement

Distortions

• Drifting (melting, breathing, morphing and flowing) - In comparison to other psychedelics, this effect can be described as highly detailed yet cartoon-like in appearance. The distortions are slow and smooth in motion and fleeting in their appearance. This is nearly identical in appearance to the visual drifting which occurs under the influence of LSD
• After images
• Colour shifting
• Depth perception distortions
• Diffraction
• Scenery slicing
• Symmetrical texture repetition
• Tracers

Geometry

The visual geometry that is present throughout this trip can be described as more similar in appearance to that of LSD, 2C-B or 2C-I than psilocin, LSA or DMT. It can be comprehensively described through its variations as primarily intricate in complexity, algorithmic in form, unstructured in organization, brightly lit, colourful in scheme, organic in feel, multicoloured in scheme, flat in shading, soft in its edges, large in size, slow in speed, smooth in motion, either angular or round in its corners, non-immersive in-depth and consistent in intensity. At higher dosages, it consistently results in states of level 8B visual geometry over level 8A.

In comparison to LSD specifically, its geometry tends to be more rounded in its corners, slightly softer in its edges and a little less intricate in its form. Aside from this, it is otherwise identical in its appearance.

Hallucinatory states

1P-ETH-LAD is capable of producing a full range of low and high-level hallucinatory states in a fashion that is a little less consistent and reproducible than that of many other commonly used psychedelics such as psilocin or DMT but considerably more likely when to compared to that of LSD. This can feel similar to the hallucinations which occur with 4-AcO-DMT but tends to occur almost exclusively at heavier dosages. These effects include:

• Transformations
• Internal hallucinations (autonomous entities; settings, sceneries, and landscapes; alterations in perspective and scenarios and plots) - This effect is very consistent in dark environments at appropriately high dosages. The hallucinations can be comprehensively described through their variations as lucid in believability, interactive in style, new experiences in content, autonomous in controllability, geometry-based in style and occasionally of a personal, religious, spiritual, science-fiction, fantasy, surreal, nonsensical or transcendental nature in their overall theme.

Auditory effects

• Distortions
• Enhancements
• Hallucinations

Experience reports

Anecdotal reports which describe the effects of this compound within our experience index include:

Additional experience reports can be found here:

• Erowid Experience Vaults: 1P-ETH-LAD

Potentially dangerous interactions

Although many substances are safe on their own, they can become dangerous and even life-threatening when combined with other substances. The list below contains some common potentially dangerous combinations, but may not include all of them. Certain combinations may be relatively harmless in low doses of each but can still increase the risk of unpredictable injury or death. Independent research should always be done to ensure that a combination of two or more substances is safe before consumption. Note that the substances listed below refer to LSD specifically; however, there is no reason to believe they do not apply equally, if not even more so, to relatively unstudied and structurally similar compounds like 1P-ETH-LAD as well.

• Tramadol - Tramadol lowers seizure threshold and psychedelics may cause occasional seizures.
• Stimulants - Stimulants may provoke anxiety or thought loops.
• Lithium - Due to its similiarity to LSD, individuals who take lithium for bipolar disorder or other psychiatric conditions should not take ETH-LAD. There are numerous anecdotal reports of seizures and or psychosis from the LSD-lithium combination.

Toxicity and harm potential

Further information: Responsible use § Hallucinogens, and Research chemicals § Toxicity and harm potential

The toxicity and long-term health effects of recreational 1P-ETH-LAD use do not seem to have been studied in any scientific context and the exact toxic dose is unknown. This is because 1P-ETH-LAD is a research chemical with very little history of human usage. Anecdotal evidence from people within the psychonaut community who have tried 1P-ETH-LAD suggests that there are no negative health effects attributed to simply trying the substance by itself at low to moderate doses and using it very sparingly (but nothing can be completely guaranteed).

Independent research should always be conducted to ensure that a combination of two or more substances is safe before consumption.

It is strongly recommended that one use harm reduction practices when using this substance.

Tolerance and addiction potential

1P-ETH-LAD is not habit-forming and the desire to use it can actually decrease with use. Like with most psychedelics, it is thought to be most often self-regulating rather than self-reinforcing.

Tolerance to the effects of 1P-ETH-LAD are built almost immediately after ingestion. After that, it takes about 3 days for the tolerance to be reduced to half and 7 days to be back at baseline (in the absence of further consumption). It should be noted that this only applies to the physiological tolerance. Mental or psychological tolerance is thought by some to take two weeks or more for the full experience to re-manifest.

Due to its activity at the 5-HT_2A receptor, 1P-ETH-LAD presents cross-tolerance with [[Cross-tolerance::all psychedelics]], meaning that after the consumption of 1P-ETH-LAD all psychedelics (particularly the tryptamines and other lysergamides) will display a reduced effect.

Legal issues

It is unclear in many countries whether this compound is legal or not and one should take precaution by assuming it is illegal to avoid legal issues.

• United States: 1P-ETH-LAD may be considered illegal in the U.S. under the Federal Analogue Act.
• United Kingdom: It is illegal to produce, supply, or import this substance under the Psychoactive Substance Act, which came into effect on May 26th, 2016.

See also

• Responsible use
• Designer drug
• Psychedelics
• Prodrug
• ETH-LAD
• 1P-LSD
• LSD