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Diarylethylamines: Difference between revisions
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[[File:Diarylethylamine.png|250px|thumbnail|The general structure for a diarylethylamine]] | [[File:Diarylethylamine.png|250px|thumbnail|The general structure for a diarylethylamine]] | ||
'''Diarylethylamines''' are [[psychoactive drug]]s, which typically have [[dissociative]] effects. | '''Diarylethylamines''' are [[psychoactive drug]]s, which typically have [[dissociative]] effects. | ||
=== | ===Pharmacology=== | ||
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Revision as of 18:57, 1 August 2017
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This article is a stub. As such, it may contain incomplete or wrong information. You can help by expanding it. |
Diarylethylamines are psychoactive drugs, which typically have dissociative effects.
Pharmacology
| Compound | IC50 ± SEM (nM) | Ki ± SEM (nM) |
|---|---|---|
| PCP[2] | 91 ± 1.3 | 57.9 ± 0.8 |
| Ketamine | 508.5 ± 30.1 | 323.9 ± 19.2 |
| Memantine | 594.2 ± 41.3 | 378.4 ± 26.3 |
| (+)-MK-801 | 4.1 ± 1.6 | 2.5 ± 1.0 |
| DPH (Diphenidine) | 28.6 ± 3.5 | 18.2 ± 2.2 |
| 2-MXP (Methoxphenidine) | 56.5 ± 5.8 | 36.0 ± 3.7 |
| 3-MXP | 30.3 ± 2.6 | 19.3 ± 1.7 |
| 4-MXP | 723.8 ± 69.9 | 461.0 ± 44.5 |
| 2-Cl-DPH | 14.6 ± 2.1 | 9.3 ± 1.3 |
NMDAR binding affinites determined using [3H]-(+)-MK-801 in rat forebrain.[3]