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'''4-HO-EPT''' (also known as ''' 4-hydroxy-N-ethyl-N-propyltryptamine''') is a new and obscure [[hallucinogen]]ic [[psychoactive class::psychedelic]] drug of the [[chemical class::tryptamine]] class.
''' 4-Hydroxy-N-ethyl-N-propyltryptamine''' (also known as '''4-HO-EPT''') is a novel synthetic [[psychoactive class::psychedelic]] substance of the [[chemical class::tryptamine]] chemical class that produces [[psychedelic]] effects when [[route of administration|administered]]. It is structurally related to [[psilocin]] ('''4-HO-DMT'''), the active component in [[psilocybin mushrooms]], and produces similar effects.
It is either used recreationally or as [[entheogen]]ic compound and is typically acquired through the use of online [[research chemical]] vendors on which it first appeared as recently as mid 2016.
Very little data exists about the pharmacological properties, metabolism, and toxicity of 4-HO-EPT. It has no history of human use before being sold online as a [[research chemical]] in 2016.{{citation needed}} It remains obscure and is either used recreationally or for research purposes.
==Chemistry==
==Chemistry==
4-HO-EPT, or 4-hydroxy-N,N-diethyltryptamine, is a synthetic indole molecule of the [[tryptamine]] class. Tryptamines share a core structure comprised of a bicylic indole heterocycle attached at R<sub>3</sub> to an amino group via an ethyl side chain. 4-HO-EPT is substituted at R<sub>4</sub> of its indole heterocycle with a hydroxyl functional group OH−. It also contains a propyl and ethyl chain bound to the terminal amine R<sub>N</sub> of its tryptamine backbone ([[EPT]]).
4-HO-EPT, or 4-hydroxy-N,N-diethyltryptamine, is a synthetic indole molecule of the [[tryptamine]] class. Tryptamines share a core structure comprised of a bicyclic indole heterocycle attached at R<sub>3</sub> to an amino group via an ethyl side chain. 4-HO-EPT is substituted at R<sub>4</sub> of its indole heterocycle with a hydroxyl functional group OH−. It also contains a propyl and ethyl chain bound to the terminal amine R<sub>N</sub> of its tryptamine backbone ([[EPT]]).
*'''[[Effect::Internal hallucinations]]''' (''[[effect::autonomous entities]]''; ''[[effect::settings, sceneries, and landscapes]]''; ''[[effect::alterations in perspective]]'' and ''[[effect::scenarios and plots]]'')
*'''[[Effect::Internal hallucinations]]''' (''[[effect::autonomous entities]]''; ''[[effect::settings, sceneries, and landscapes]]''; ''[[effect::alterations in perspective]]'' and ''[[effect::scenarios and plots]]'')
{{further|Research chemicals#Toxicity and harm potential|Responsible use #Hallucinogens}}
{{further|Research chemicals#Toxicity and harm potential|Responsible use #Hallucinogens}}
The toxicity and long-term health effects of recreational 4-HO-EPT use do not seem to have been studied in any scientific context and the exact [[Toxicity::toxic dose is unknown]]. This is because 4-HO-EPT is a [[research chemical]] with very little history of human usage. Anecdotal evidence from people within the psychonaut community who have tried 4-HO-EPT suggests that there are no negative health effects attributed to simply trying the drug by itself at low to moderate doses and using it very sparingly (but nothing can be completely guaranteed). [https://www.google.com/ Independent research] should always be done to ensure that a combination of two or more substances is safe before consumption.
The toxicity and long-term health effects of recreational 4-HO-EPT use do not seem to have been studied in any scientific context and the exact [[Toxicity::toxic dose is unknown]]. This is because 4-HO-EPT is a [[research chemical]] with very little history of human usage.
Anecdotal evidence from people within the community who have tried 4-HO-EPT suggests that there are no negative health effects attributed to simply trying the it by itself at low to moderate doses and using it very sparingly (but nothing can be completely guaranteed). [https://www.google.com/ Independent research] should always be done to ensure that a combination of two or more substances is safe before consumption.
It is strongly recommended that one use [[responsible drug use|harm reduction practices]] when using this drug.
It is strongly recommended that one use [[responsible drug use|harm reduction practices]] when using this substance.
===Tolerance and addiction potential===
===Tolerance and addiction potential===
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Tolerance to the effects of 4-HO-EPT are built [[Time to full tolerance::almost immediately after ingestion]]. After that, it takes about [[Time to half tolerance::3 days]] for the tolerance to be reduced to half and [[Time to zero tolerance::7 days]] to be back at baseline (in the absence of further consumption). 4-HO-EPT presents cross-tolerance with [[Cross-tolerance::all [[psychedelic]]s]], meaning that after the consumption of 4-HO-EPT all psychedelics will have a reduced effect.
Tolerance to the effects of 4-HO-EPT are built [[Time to full tolerance::almost immediately after ingestion]]. After that, it takes about [[Time to half tolerance::3 days]] for the tolerance to be reduced to half and [[Time to zero tolerance::7 days]] to be back at baseline (in the absence of further consumption). 4-HO-EPT presents cross-tolerance with [[Cross-tolerance::all [[psychedelic]]s]], meaning that after the consumption of 4-HO-EPT all psychedelics will have a reduced effect.
==Legal issues==
==Legality==
{{legalStub}}
Due to its relative obscurity, the possession and sale of 4-HO-EPT is unscheduled in most countries.
Due to its relative obscurity, the possession and sale of 4-HO-EPT is unscheduled in most countries.
WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section.
DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.
4-Hydroxy-N-ethyl-N-propyltryptamine (also known as 4-HO-EPT) is a novel synthetic psychedelic substance of the tryptamine chemical class that produces psychedelic effects when administered. It is structurally related to psilocin (4-HO-DMT), the active component in psilocybin mushrooms, and produces similar effects.
Very little data exists about the pharmacological properties, metabolism, and toxicity of 4-HO-EPT. It has no history of human use before being sold online as a research chemical in 2016.[citation needed] It remains obscure and is either used recreationally or for research purposes.
4-HO-EPT, or 4-hydroxy-N,N-diethyltryptamine, is a synthetic indole molecule of the tryptamine class. Tryptamines share a core structure comprised of a bicyclic indole heterocycle attached at R3 to an amino group via an ethyl side chain. 4-HO-EPT is substituted at R4 of its indole heterocycle with a hydroxyl functional group OH−. It also contains a propyl and ethyl chain bound to the terminal amine RN of its tryptamine backbone (EPT).
Like with most psychedelic tryptamines, 4-HO-EPT is thought to act principally as a 5-HT2Apartial agonist. The psychedelic effects are believed to come from 4-HO-EPT's binding efficacy at the 5-HT2A receptors. However, the role of these interactions and how they result in the psychedelic experience continues to remain elusive.
Disclaimer: The effects listed below cite the Subjective Effect Index (SEI), an open research literature based on anecdotal user reports and the personal analyses of PsychonautWikicontributors. As a result, they should be viewed with a healthy degree of skepticism.
It is also worth noting that these effects will not necessarily occur in a predictable or reliable manner, although higher doses are more liable to induce the full spectrum of effects. Likewise, adverse effects become increasingly likely with higher doses and may include addiction, severe injury, or death ☠.
The toxicity and long-term health effects of recreational 4-HO-EPT use do not seem to have been studied in any scientific context and the exact toxic dose is unknown. This is because 4-HO-EPT is a research chemical with very little history of human usage.
Anecdotal evidence from people within the community who have tried 4-HO-EPT suggests that there are no negative health effects attributed to simply trying the it by itself at low to moderate doses and using it very sparingly (but nothing can be completely guaranteed). Independent research should always be done to ensure that a combination of two or more substances is safe before consumption.
4-HO-EPT is not habit-forming and the desire to use it can actually decrease with regular consumption. Like with most psychedelics, it is most often thought to be self-regulating.
Tolerance to the effects of 4-HO-EPT are built almost immediately after ingestion. After that, it takes about 3 days for the tolerance to be reduced to half and 7 days to be back at baseline (in the absence of further consumption). 4-HO-EPT presents cross-tolerance with [[Cross-tolerance::all psychedelics]], meaning that after the consumption of 4-HO-EPT all psychedelics will have a reduced effect.
As such, it may contain incomplete or wrong information. You can help by expanding it.
Due to its relative obscurity, the possession and sale of 4-HO-EPT is unscheduled in most countries.
United Kingdom - 4-HO-EPT is a Class A drug in the United Kingdom as a result of the tryptamine catch-all clause.[1]
United States - 4-HO-EPT is unscheduled in the United States. It may be considered an analogue of psilocin (which is a Schedule I drug under the Controlled Substances Act). As such, the sale for human consumption or the use for illicit non-medical or industrial intents and purposes could be prosecuted as crimes under the Federal Analogue Act.
