Clonidine: Difference between revisions
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The treatment for clonidine overdose is [[naloxone]]. | The treatment for clonidine overdose is [[naloxone]]. | ||
===Tolerance and addiction potential=== | ===Tolerance and addiction potential=== | ||
Clonidine seems to be able to cause addiction and can be tolerated over periods of time. It is used concurrently with prescription pain-killers ([[opioids]]) | Clonidine seems to be able to cause addiction and can be tolerated over periods of time. It is used concurrently with prescription pain-killers ([[opioids]]) recreationally because it might have potentiating effects, but this has not been studied. | ||
==Legal issues== | ==Legal issues== | ||
Revision as of 01:44, 12 July 2017
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This page has not been fully approved by the PsychonautWiki administrators. It may contain incorrect information, particularly with respect to dosage, duration, subjective effects, toxicity and other risks. It may also not meet PW style and grammar standards. |
Template:SubstanceBox/clonidine
Chemistry
Clonidine is an imdiazoline compound, meaning that its main chemistry is of an imidazole ring. A nitrogen bonded to the imidazole and chlorinated phenyl group makes an amine.
Pharmacology
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This pharmacology section is incomplete. You can help by adding to it. |
Binding affinities:
- Alpha 1A receptor: 316.23 nM
- Alpha 1B receptor: 316.23 nM
- Alpha 1D receptor: 125.89 nM
- Alpha 2A receptor: 42.92 nM
- Alpha 2B receptor: 106.31 nM
- Alpha 2C receptor: 233.1 nM
Subjective effects
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This subjective effects section is a stub. As such, it is still in progress and may contain incomplete or wrong information. You can help by expanding or correcting it. |
Toxicity and harm potential
It is strongly recommended that one use harm reduction practices when using this drug, especially concurrently with other depressants.
Lethal dosage
According to dailymed.nlm.nih.gov's prescribing information page for clonidine, clonidine's oral LD50 in mice is 206 mg/kg and for rats, 465 mg/kg. Of course, this does not mean one will not die with levels below these. The treatment for clonidine overdose is naloxone.
Tolerance and addiction potential
Clonidine seems to be able to cause addiction and can be tolerated over periods of time. It is used concurrently with prescription pain-killers (opioids) recreationally because it might have potentiating effects, but this has not been studied.
Legal issues
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This legality section is a stub. As such, it may contain incomplete or wrong information. You can help by expanding it. |
United States: In the US, clonidine is only available through prescription.
See also
References
https://pubchem.ncbi.nlm.nih.gov/compound/clonidine#section=Names-and-Identifiers http://onlinelibrary.wiley.com/doi/10.1002/ddr.430020207/full
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