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'''25N-NBOMe''' ('''2C-N-NBOMe''') is a derivative of the [[Chemical class::Phenethylamine|substituted phenethylamine]] [[Psychoactive class::psychedelic]] [[2C-N]], which was discovered in 2004 by Ralf Heim at the Free University of Berlin<ref name="Ralf Heim PhD. (2010-02-28)">Ralf Heim PhD. (2010-02-28) "Synthese und Pharmakologie potenter 5-HT2A-Rezeptoragonisten mit N-2-Methoxybenzyl-Partialstruktur. Entwicklung eines neuen Struktur-Wirkungskonzepts." | http://www.diss.fu-berlin.de/diss/receive/FUDISS_thesis_000000001221 (in German). diss.fu-berlin.de. Retrieved 2013-05-10.</ref> and subsequently investigated by a team at Purdue University led by [[David E. Nichols]].<ref name="Michael Robert Braden PhD. (2007)">Michael Robert Braden PhD. (2007). "Towards a biophysical understanding of hallucinogen action." | http://proquest.umi.com/pqdlink?Ver=1&Exp=01-23-2014&FMT=7&DID=1417800971&RQT=309&attempt=1&cfc=1 Purdue University. Retrieved 2012-08-08.</ref>
'''25N-NBOMe''' (also known as '''2C-N-NBOMe''' and '''N-Bomb''', although this term is used broadly to refer to the entire [[25x-NBOMe]] family) is novel synthetic [[Psychoactive class::psychedelic]] substance of the [[chemical class::phenethylamine]] chemical class. It produces an array of visually-dominant and stimulating [[psychedelic]] effects when [[Routes of administration|administered]].
25N-NBOMe has a notably shorter duration than the rest of the [[25x-NBOMe]] series with a total duration of 6 hours and a peak duration of 2 hours.<ref>http://www.bluelight.org/vb/threads/539694-The-Big-amp-Dandy-25N-NBOMe-Thread</ref> It is moderately active at a dose of one milligram, and two milligrams provide a strong/heavy trip.<ref>https://www.drugs-forum.com/forum/showthread.php?t=249067</ref> This substance is considerably less potent when compared to the more popular NBOMe compunds such as [[25B-NBOMe]], [[25I-NBOMe]] and [[25C-NBOMe]], all which lead to strong trips at 1mg+ doses.{{citation needed}}
The name 25I-NBOMe, which short-hand for 2C-I-NBOMe, is a derivative of the phenethylamine psychedelic 2C-N. It was discovered in 2004 by Ralf Heim at the Free University of Berlin<ref name="Ralf Heim PhD. (2010-02-28)">Ralf Heim PhD. (2010-02-28) "Synthese und Pharmakologie potenter 5-HT2A-Rezeptoragonisten mit N-2-Methoxybenzyl-Partialstruktur. Entwicklung eines neuen Struktur-Wirkungskonzepts." | http://www.diss.fu-berlin.de/diss/receive/FUDISS_thesis_000000001221 (in German). diss.fu-berlin.de. Retrieved 2013-05-10.</ref> and subsequently investigated by a team at Purdue University led by [[David E. Nichols]].<ref name="Michael Robert Braden PhD. (2007)">Michael Robert Braden PhD. (2007). "Towards a biophysical understanding of hallucinogen action." | http://proquest.umi.com/pqdlink?Ver=1&Exp=01-23-2014&FMT=7&DID=1417800971&RQT=309&attempt=1&cfc=1 Purdue University. Retrieved 2012-08-08.</ref>
25N-NBOMe has a notably shorter duration than the rest of the [[25x-NBOMe]] series with a total duration of 6 hours and a peak duration of 2 hours.<ref>http://www.bluelight.org/vb/threads/539694-The-Big-amp-Dandy-25N-NBOMe-Thread</ref> It is moderately active at a dose of one milligram, and two milligrams provide a strong/heavy trip.<ref>https://www.drugs-forum.com/forum/showthread.php?t=249067</ref> This substance is considerably less potent when compared to the more popular NBOMe compunds such as [[25B-NBOMe]], [[25I-NBOMe]] and [[25C-NBOMe]], all which lead to strong experiences at doses above 1mg.{{citation needed}} It is worth noting that compounds of the [[25x-NBOMe|NBOMe]] family are not [[orally]] active and should be administered [[sublingual|sublingually]] by placing and holding it into one's mouth and allowing it to absorb over a period of 15-25 minutes.
This substance had no history of human use before being sold online as a [[designer drug]] in 2010.{{citation needed}} Extremely little is known about the pharmacological properties, metabolism, and toxicity of 25N-NBOMe in humans, and many members of the [[25x-NBOMe]] series have been associated with deaths and hospitalizations. Along with its highly sensitive dose-response and unpredictable effects, many reports also suggest that this substance may be overly difficult to use safely. Therefore it is highly advised to approach this poorly understood [[psychedelic]] substance with the proper amount of precaution and [[Responsible drug use#Hallucinogens|harm reduction practices]] if choosing to use it.
==Chemistry==
==Chemistry==
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==Subjective effects==
==Subjective effects==
The effects listed below are based upon the subjective effects index and personal experiences of [[PsychonautWiki]] contributors. The listed effects will rarely (if ever) occur all at once, but heavier dosages will increase the chances and are more likely to induce a full range of effects.
{{Preamble/SubjectiveEffects}}
{{effects/base
===Physical effects===
|{{effects/physical|
*'''[[Effect::Stimulation]]''' - In terms of its effects on the physical energy levels of the user, 25N-NBOMe is usually considered to be very energetic and stimulating. For most people, this substance induces a unique type of physical stimulation which can be described as feeling extremely energetic but in a way which does not force the tripper to move unless they genuinely choose to do so. For others, however, the stimulation can be quite uncontrollable, occasionally resulting in bodily shakes and a grinding of the teeth comparable to that of [[MDMA]] and traditional stimulants such as [[amphetamine]].
*'''[[Effect::Perception of bodily lightness]]''' - In terms of the body’s perceived weight, this substance consistently leaves people feeling extremely light, often to the point of total weightlessness.
*'''[[Effect::Spontaneous physical sensations]]''' - The "body high" itself can be described as a mild, all-encompassing, soft but euphoric tingling sensation. This tingling sensation is also accompanied by spontaneous rushes of [[Physical euphoria|euphoria]] that become longer and more drawn out proportional to the dosage consumed.
**'''[[Effect::Physical euphoria]]'''
*'''[[Effect::Tactile enhancement]]'''
*'''[[Effect::Bodily control enhancement]]''' - When combined with stimulation, this component manifests as a strong drive to partake in physical activities.
*'''[[Effect::Bodily control enhancement]]''' - When combined with stimulation, this component manifests as a strong drive to partake in physical activities.
*'''[[Effect::Mouth numbing]]''' - Assuming the substance has been taken [[sublingual]]ly, the very first physical effect which a person will notice immediately after sublingual absorption is a strong, unpleasant metallic chemical taste. This is accompanied by a very distinct feeling of general numbness of the tongue and mouth which can stay for up to an hour after the blotter paper has been consumed.
*'''[[Effect::Abnormal heartbeat]]'''
*'''[[Effect::Increased heart rate]]'''
*'''[[Effect::Increased heart rate]]'''
*'''[[Effect::Increased blood pressure]]'''
*'''[[Effect::Muscle contractions]]'''
*'''[[Effect::Muscle cramps]]'''
*'''[[Effect::Muscle tension]]'''
*'''[[Effect::Gustatory hallucinations]]'''
*'''[[Effect::Nausea]]''' - Users (especially those prone to it) may experience nausea during the [[come up]]. The nausea will subside over the peak.
*'''[[Effect::Nausea]]''' - Users (especially those prone to it) may experience nausea during the [[come up]]. The nausea will subside over the peak.
*'''[[Effect::Appetite suppression]]'''
*'''[[Effect::Runny nose]]''' - 25N-NBOMe may cause a runny nose and increased mucus production in some users.
*'''[[Effect::Stomach cramps]]'''
*'''[[Effect::Dehydration]]'''
*'''[[Effect::Dry mouth]]'''
*'''[[Effect::Difficulty urinating]]''' or '''[[Effect::Frequent urination]]'''
*'''[[Effect::Restless legs]]'''
*'''[[Effect::Pupil dilation]]'''
*'''[[Effect::Pupil dilation]]'''
*'''[[Effect::Runny nose]]''' - 25N-NBOMe may cause a runny nose and increased mucus production in some users.
*'''[[Effect::Headaches]]'''
*'''[[Effect::Stimulation]]''' - In terms of its effects on the energy levels of the tripper, 25N-NBOMe is quite stimulating, and leftover stimulation can linger up to 10 hours even after the trip subsides.
*'''[[Effect::Seizures]]'''
*'''[[Effect::Tactile enhancement]]'''
*'''[[Effect::Vasoconstriction]]'''
*'''[[Effect::Wakefulness]]'''
===Cognitive effects===
}}
The cognitive effects of 25N-NBOMe can be described as quite reminiscent to that of [[25C-NBOMe]]. They can be broken down into several components which progressively intensify proportional to dosage. These are described below and generally include:
{{effects/visual|
*'''[[Effect::Analysis enhancement]]''' - This component is [[introspection]] dominant.
*'''[[Effect::Conceptual thinking]]'''
*'''[[Effect::Emotionality enhancement]]'''
*'''[[Effect::Perception of self-design]]'''
*'''[[Effect::Increased music appreciation]]'''
*'''[[Effect::Laughter]]'''
*'''[[Effect::Memory suppression]]'''
**'''[[Effect::Ego death]]'''
*'''[[Effect::Novelty enhancement]]'''
*'''[[Effect::Thought connectivity]]'''
*'''[[Effect::Time distortion]]'''
*'''[[Effect::Wakefulness]]'''
===Visual effects===
====Enhancements====
====Enhancements====
*'''[[Effect::Visual acuity enhancement]]'''
*'''[[Effect::Visual acuity enhancement]]'''
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*'''[[Effect::Internal hallucinations|Internal hallucinations]]''' (''[[effect::autonomous entities]]''; ''[[effect::settings, sceneries, and landscapes]]''; ''[[effect::alterations in perspective]]'' and ''[[effect::scenarios and plots]]'') - 25N-NBOMe is capable of producing a full range of hallucinatory states within the level 1 - 3 range extremely consistently. Level 4 hallucinatory breakthroughs are reported, but very uncommon and inconsistent in comparison to other more commonly used psychedelics such as [[psilocin]], [[2C-E]] and [[DMT]]. This effect is more common within dark environments and can be described as internal in its manifestation, lucid in believability, interactive in style and of no particular theme in content or style.
*'''[[Effect::Internal hallucinations|Internal hallucinations]]''' (''[[effect::autonomous entities]]''; ''[[effect::settings, sceneries, and landscapes]]''; ''[[effect::alterations in perspective]]'' and ''[[effect::scenarios and plots]]'') - 25N-NBOMe is capable of producing a full range of hallucinatory states within the level 1 - 3 range extremely consistently. Level 4 hallucinatory breakthroughs are reported, but very uncommon and inconsistent in comparison to other more commonly used psychedelics such as [[psilocin]], [[2C-E]] and [[DMT]]. This effect is more common within dark environments and can be described as internal in its manifestation, lucid in believability, interactive in style and of no particular theme in content or style.
===Auditory effects===
}}
|{{effects/cognitive|
The cognitive effects of 25N-NBOMe can be described as quite reminiscent to that of [[25C-NBOMe]]. They can be broken down into several components which progressively intensify proportional to dosage. These are described below and generally include:
*'''[[Effect::Analysis enhancement]]''' - This effect is generally only present at low doses and is [[introspection]] dominant.
*'''[[Effect::Thought acceleration]]''' and '''[[Effect::Thought deceleration]]''' - Although one of 25N-NBOME's effects is thought acceleration, the opposite may occur at higher doses.
*'''[[Effect::Conceptual thinking]]''' - This effect is considered to be very mild compared to traditional psychedlics.
*'''[[Effect::Anxiety]]''' & '''[[Effect::Paranoia]]''' - This effect seems to occur more readily than other psychedelics, perhaps due to its very prominent stimulating properties
*'''[[Effect::Empathy, affection, and sociability enhancement]]''' - The [[entactogenic]] effects range from mild to powerful, but are inconsistently manifested. Entactogenic effects for people who try this substance usually become prominent in the presence of others. These feelings of increased sociability, love and empathy do not seem to be quite as strong or profound as those found within other [[entactogen|entactogens]] (such as [[MDMA]], [[2C-B]] and [[AMT]])
*'''[[Effect::Dosage independent intensity]]''' - While the reasons for this are not understood, many reports suggest that this substance can produce unexpectedly strong or weak effects even when taken at the seemingly same dose in an unpredictable manner.{{citation needed}} This may contribute to the relative risk it is poses compared to most other psychedelics.
*'''[[Effect::Synaesthesia]]''' - In its fullest manifestation, this is a very rare and non-reproducible effect. Increasing the dosage can increase the likelihood of this occurring, but seems to only be a prominent part of the experience among those who are already predisposed to synaesthetic states.
}}
{{effects/transpersonal|
While they are occasionally reported, the transpersonal effects produced by this substance seem to be significantly less consistent and reproducible than other [[psychedelics]], which perhaps corresponds with the notably mild changes to one's perceptual and cognitive processes.
*'''[[Effect::Existential self-realization]]'''
*'''[[Effect::Unity and interconnectedness]]'''
}}
}}
==Toxicity and harm potential==
==Toxicity and harm potential==
{{further|Research chemicals#Toxicity and harm potential|Responsible use #Hallucinogens}}
{{further|Research chemicals#Toxicity and harm potential|Responsible use #Hallucinogens}}
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{{DangerousInteractions}}
{{DangerousInteractions}}
Although many substances are safe on their own, they can become dangerous and even life-threatening when combined with other substances. The list below contains some common potentially dangerous combinations, but may not include all of them. Certain combinations may be relatively harmless in low doses of each but can still increase the risk of unpredictable injury or death. [https://www.google.com/ Independent research] should always be done to ensure that a combination of two or more substances is safe before consumption.
Although many substances are safe on their own, they can become dangerous and even life-threatening when combined with other substances. The list below contains some common potentially dangerous combinations, but may not include all of them. Certain combinations may be relatively harmless in low doses of each but can still increase the risk of unpredictable injury or death. [https://www.google.com/ Independent research] should always be done to ensure that a combination of two or more substances is safe before consumption.
*'''[[Tramadol]]''' - Tramadol lowers seizure threshold<ref>Talaie, H., Panahandeh, R., Fayaznouri, M. R., Asadi, Z., & Abdollahi, M. (2009). Dose-independent occurrence of seizure with tramadol. Journal of medical toxicology, 5(2), 63-67. doi:10.1007/BF03161089</ref> and psychedelics may act as triggers for seizures, particularly in those who are predisposed to them.<ref name"tripsit">http://wiki.tripsit.me/wiki/Drug_combinations</ref><ref>Fisher, D. D., & Ungerleider, J. T. (1967). [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1502729/ Grand mal seizures following ingestion of LSD]. California Medicine, 106(3), 210. PMCID: PMC1502729</ref><ref>Question ID: 2837 (Ask Erowid) | https://www.erowid.org/ask/ask.php?ID=2837</ref>
*'''[[Stimulants]]''' - Combining stimulants with psychedelics may induce states of uncontrollable anxiety, over-stimulation, [[thought loops]], and increase the risk of psychosis.<ref>Tripsit Factsheets - LSD | http://drugs.tripsit.me/lsd</ref>
*'''[[Tramadol]]''' - Tramadol lowers the seizure threshold<ref>Talaie, H., Panahandeh, R., Fayaznouri, M. R., Asadi, Z., & Abdollahi, M. (2009). Dose-independent occurrence of seizure with tramadol. Journal of medical toxicology, 5(2), 63-67. doi:10.1007/BF03161089</ref> and [[psychedelics]] may act as triggers for seizures, particularly in those who are predisposed to them.{{citation needed}}
*'''[[Stimulants]]''' - Stimulants affect many parts of the brain. Combined with psychedelics, stimulation can turn into uncontrollable [[anxiety]], [[Panic attacks|panic]], [[thought loops]] and [[paranoia]]. This interaction may cause elevated risk of psychosis.{{citation needed}}
*'''[https://en.wikipedia.org/wiki/Lithium_(medication) Lithium]''' - Lithium is often used as treatment for bipolar disorder. It may possibly cause elevated risk of seizures and psychosis due to its [[Glutamate|glutaminergic]] and [[GABA|GABAergic]] effects.{{citation needed}}
==Legal issues==
==Legality==
{{legalStub}}
*'''Brazil''' - Possession, production and sale is illegal as it is listed on Portaria SVS/MS nº 344.<ref>http://portal.anvisa.gov.br/documents/10181/3115436/%281%29RDC_130_2016_.pdf/fc7ea407-3ff5-4fc1-bcfe-2f37504d28b7</ref>
*'''Brazil''' - Possession, production and sale is illegal as it is listed on Portaria SVS/MS nº 344.<ref>http://portal.anvisa.gov.br/documents/10181/3115436/%281%29RDC_130_2016_.pdf/fc7ea407-3ff5-4fc1-bcfe-2f37504d28b7</ref>
*'''USA:''' 25N-NBOMe is unscheduled in the United States. It may be considered an analog of [[2C-N]] (which is a Schedule I drug under the Controlled Substances Act). As such, the sale for human consumption or the use for illicit non-medical or industrial intents and purposes could be prosecuted as crimes under the Federal Analog Act.
*'''UK:''' On 10 June 2014, all NBOMes became Class A drugs which means that they’re illegal to have, give away or sell. Possession could get one up to seven years in jail and/or an unlimited fine. Supplying someone else could result in a heavy jail time sentence between a minimum of eight years and a life sentence and/or an unlimited fine.<ref>http://www.talktofrank.com/drug/n-bomb</ref>
*'''Latvia:''' 25N-NBOMe is a Schedule I controlled substance.<ref>Noteikumi par Latvijā kontrolējamajām narkotiskajām vielām, psihotropajām vielām un prekursoriem (2,5-Dimetoksifeniletānamīni) | http://likumi.lv/doc.php?id=121086</ref>
*'''Latvia:''' 25N-NBOMe is a Schedule I controlled substance.<ref>Noteikumi par Latvijā kontrolējamajām narkotiskajām vielām, psihotropajām vielām un prekursoriem (2,5-Dimetoksifeniletānamīni) | http://likumi.lv/doc.php?id=121086</ref>
*'''United Kingdom:''' On 10 June 2014, all NBOMes became Class A drugs which means that they’re illegal to have, give away or sell. Possession could get one up to seven years in jail and/or an unlimited fine. Supplying someone else could result in a heavy jail time sentence between a minimum of eight years and a life sentence and/or an unlimited fine.<ref>http://www.talktofrank.com/drug/n-bomb</ref>
*'''United States:''' 25N-NBOMe is unscheduled in the United States. It may be considered an analog of 2C-N (which is a Schedule I drug under the Controlled Substances Act). As such, the sale for human consumption or the use for illicit non-medical or industrial intents and purposes could be prosecuted as crimes under the Federal Analog Act.
==See also==
==See also==
*[[Responsible use]]
*[[Responsible use]]
*[[Research chemical]]
*[[Psychedelic]]
*[[Psychedelic]]
*[[Stimulant]]
*[[Stimulant]]
*[[25B-NBOMe]]
*[[25x-NBOMe]]
*[[25C-NBOMe]]
*[[25C-NBOMe]]
*[[25I-NBOMe]]
*[[25I-NBOMe]]
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{{#set:Featured=true}}
{{#set:Featured=true}}
[[Category:Psychoactive substance]]
[[Category:Psychoactive substance]]
[[Category:Substance]]
[[Category:Research chemical]]
[[Category:Phenethylamine]]
[[Category:Phenethylamine]]
[[Category:Psychedelic]]
[[Category:Psychedelic]]
Revision as of 20:37, 14 June 2017
Members of the NBOMe series have been linked to numerous overdoses and fatalities.[1][2][3]
It is strongly discouraged to insufflate (snort) or take higher doses of these compounds. Please see this section for more details.
WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section.
DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.
25N-NBOMe (also known as 2C-N-NBOMe and N-Bomb, although this term is used broadly to refer to the entire 25x-NBOMe family) is novel synthetic psychedelic substance of the phenethylamine chemical class. It produces an array of visually-dominant and stimulating psychedelic effects when administered.
The name 25I-NBOMe, which short-hand for 2C-I-NBOMe, is a derivative of the phenethylamine psychedelic 2C-N. It was discovered in 2004 by Ralf Heim at the Free University of Berlin[4] and subsequently investigated by a team at Purdue University led by David E. Nichols.[5]
25N-NBOMe has a notably shorter duration than the rest of the 25x-NBOMe series with a total duration of 6 hours and a peak duration of 2 hours.[6] It is moderately active at a dose of one milligram, and two milligrams provide a strong/heavy trip.[7] This substance is considerably less potent when compared to the more popular NBOMe compunds such as 25B-NBOMe, 25I-NBOMe and 25C-NBOMe, all which lead to strong experiences at doses above 1mg.[citation needed] It is worth noting that compounds of the NBOMe family are not orally active and should be administered sublingually by placing and holding it into one's mouth and allowing it to absorb over a period of 15-25 minutes.
This substance had no history of human use before being sold online as a designer drug in 2010.[citation needed] Extremely little is known about the pharmacological properties, metabolism, and toxicity of 25N-NBOMe in humans, and many members of the 25x-NBOMe series have been associated with deaths and hospitalizations. Along with its highly sensitive dose-response and unpredictable effects, many reports also suggest that this substance may be overly difficult to use safely. Therefore it is highly advised to approach this poorly understood psychedelic substance with the proper amount of precaution and harm reduction practices if choosing to use it.
25N-NBOMe or 2C-N-NBOMe is a serotonergic N-benzyl derivative of the substituted phenethylamine psychedelic known as 2C-N. 25N-NBOMe is a substituted phenethylamine with methoxy groups CH3O- attached to carbons R2 and R5 as well as a nitro group NO2- attached to carbon R4. It differs from 2C-N structurally through a substitution on the amine (NH2) with a 2-methoxybenzyl (BOMe) group as shown in the image to the right. 25N-NBOMe shares this 2-methoxybenzyl substitution with other chemicals of the NBOMe family. This NBOMe addition contains a methoxy ether CH3O- bound to a benzene ring at R2.
25N-NBOMe likely has efficacy at the 5-HT2A receptor where it is assumed to act as a partial agonist. However, the role of these interactions and how they result in the psychedelic experience continues to remain elusive.
There is insufficient scientific research to determine this compound's true nature as the pharmacological properties of 25N-NBOMe have not been described in the scientific literature, but only in anecdotal reports.[8]
Subjective effects
Disclaimer: The effects listed below cite the Subjective Effect Index (SEI), an open research literature based on anecdotal user reports and the personal analyses of PsychonautWikicontributors. As a result, they should be viewed with a healthy degree of skepticism.
It is also worth noting that these effects will not necessarily occur in a predictable or reliable manner, although higher doses are more liable to induce the full spectrum of effects. Likewise, adverse effects become increasingly likely with higher doses and may include addiction, severe injury, or death ☠.
Physical effects
Stimulation - In terms of its effects on the physical energy levels of the user, 25N-NBOMe is usually considered to be very energetic and stimulating. For most people, this substance induces a unique type of physical stimulation which can be described as feeling extremely energetic but in a way which does not force the tripper to move unless they genuinely choose to do so. For others, however, the stimulation can be quite uncontrollable, occasionally resulting in bodily shakes and a grinding of the teeth comparable to that of MDMA and traditional stimulants such as amphetamine.
Perception of bodily lightness - In terms of the body’s perceived weight, this substance consistently leaves people feeling extremely light, often to the point of total weightlessness.
Spontaneous physical sensations - The "body high" itself can be described as a mild, all-encompassing, soft but euphoric tingling sensation. This tingling sensation is also accompanied by spontaneous rushes of euphoria that become longer and more drawn out proportional to the dosage consumed.
Bodily control enhancement - When combined with stimulation, this component manifests as a strong drive to partake in physical activities.
Mouth numbing - Assuming the substance has been taken sublingually, the very first physical effect which a person will notice immediately after sublingual absorption is a strong, unpleasant metallic chemical taste. This is accompanied by a very distinct feeling of general numbness of the tongue and mouth which can stay for up to an hour after the blotter paper has been consumed.
Drifting(melting, flowing, breathing and morphing) - In comparison to other psychedelics, this effect can be described as highly detailed, slow and smooth in motion, static in appearance and unrealistic/cartoon-like in style.
The visual geometry that is present throughout this trip is often described as similar in appearance to that of LSD. It can be comprehensively described as algorithmic in style, intricate in complexity, fine and zoomed out in detail, fast and smooth in motion, structured in shape, colourful in scheme, glossy in colour, sharp around its edges and mostly rounded across its corners.
In terms of its behaviour, 25N-NBOMe’s geometry leads onto level 8A visual geometry with level 8B remaining so far unconfirmed within this substance. It also seems to consistently build up in visual intensity when the tripper stares at a central point. This eventually envelops the visual field and creates the sensation that the tripper has broken through into a continuously shifting geometric landscape or structure with a vast sense of physical size attributed to it.
Internal hallucinations (autonomous entities; settings, sceneries, and landscapes; alterations in perspective and scenarios and plots) - 25N-NBOMe is capable of producing a full range of hallucinatory states within the level 1 - 3 range extremely consistently. Level 4 hallucinatory breakthroughs are reported, but very uncommon and inconsistent in comparison to other more commonly used psychedelics such as psilocin, 2C-E and DMT. This effect is more common within dark environments and can be described as internal in its manifestation, lucid in believability, interactive in style and of no particular theme in content or style.
Cognitive effects
The cognitive effects of 25N-NBOMe can be described as quite reminiscent to that of 25C-NBOMe. They can be broken down into several components which progressively intensify proportional to dosage. These are described below and generally include:
Conceptual thinking - This effect is considered to be very mild compared to traditional psychedlics.
Anxiety & Paranoia - This effect seems to occur more readily than other psychedelics, perhaps due to its very prominent stimulating properties
Empathy, affection, and sociability enhancement - The entactogenic effects range from mild to powerful, but are inconsistently manifested. Entactogenic effects for people who try this substance usually become prominent in the presence of others. These feelings of increased sociability, love and empathy do not seem to be quite as strong or profound as those found within other entactogens (such as MDMA, 2C-B and AMT)
Dosage independent intensity - While the reasons for this are not understood, many reports suggest that this substance can produce unexpectedly strong or weak effects even when taken at the seemingly same dose in an unpredictable manner.[citation needed] This may contribute to the relative risk it is poses compared to most other psychedelics.
Synaesthesia - In its fullest manifestation, this is a very rare and non-reproducible effect. Increasing the dosage can increase the likelihood of this occurring, but seems to only be a prominent part of the experience among those who are already predisposed to synaesthetic states.
While they are occasionally reported, the transpersonal effects produced by this substance seem to be significantly less consistent and reproducible than other psychedelics, which perhaps corresponds with the notably mild changes to one's perceptual and cognitive processes.
The toxicity and long-term health effects of recreational 25N-NBOMe use have not been studied in any scientific context and the exact toxic dosage is unknown. This is because 25N-NBOMe is a research chemical with very little history of human usage. Anecdotal evidence from people within the psychonaut community who have tried 25N-NBOMe suggests that there are no negative health effects attributed to simply trying the drug by itself at low to moderate doses and using it very sparingly (but nothing can be completely guaranteed).
Users should be very careful and consider that ingesting 2mg+ of NBOMe series chemicals have proven fatal in some cases. Although there are no reported deaths caused by 25N-NBOMe at this time, it is a rare research chemical with very little history of human usage and is therefore potentially fatal at heavy dosages.
25N-NBOMe is not habit-forming and the desire to use it can actually decrease with use. It is most often self-regulating.
Tolerance to the effects of 25N-NBOMe are built almost immediately after ingestion. After that, it takes about 3 days for the tolerance to be reduced to half and 7 days to be back at baseline (in the absence of further consumption). 25N-NBOMe presents cross-tolerance with [[Cross-tolerance::all psychedelics]], meaning that after the consumption of 25N-NBOMe all psychedelics will have a reduced effect.
Although many substances are safe on their own, they can become dangerous and even life-threatening when combined with other substances. The list below contains some common potentially dangerous combinations, but may not include all of them. Certain combinations may be relatively harmless in low doses of each but can still increase the risk of unpredictable injury or death. Independent research should always be done to ensure that a combination of two or more substances is safe before consumption.
Tramadol - Tramadol lowers the seizure threshold[9] and psychedelics may act as triggers for seizures, particularly in those who are predisposed to them.[citation needed]
Stimulants - Stimulants affect many parts of the brain. Combined with psychedelics, stimulation can turn into uncontrollable anxiety, panic, thought loops and paranoia. This interaction may cause elevated risk of psychosis.[citation needed]
Lithium - Lithium is often used as treatment for bipolar disorder. It may possibly cause elevated risk of seizures and psychosis due to its glutaminergic and GABAergic effects.[citation needed]
As such, it may contain incomplete or wrong information. You can help by expanding it.
Brazil - Possession, production and sale is illegal as it is listed on Portaria SVS/MS nº 344.[10]
Latvia: 25N-NBOMe is a Schedule I controlled substance.[11]
United Kingdom: On 10 June 2014, all NBOMes became Class A drugs which means that they’re illegal to have, give away or sell. Possession could get one up to seven years in jail and/or an unlimited fine. Supplying someone else could result in a heavy jail time sentence between a minimum of eight years and a life sentence and/or an unlimited fine.[12]
United States: 25N-NBOMe is unscheduled in the United States. It may be considered an analog of 2C-N (which is a Schedule I drug under the Controlled Substances Act). As such, the sale for human consumption or the use for illicit non-medical or industrial intents and purposes could be prosecuted as crimes under the Federal Analog Act.
↑Ralf Heim PhD. (2010-02-28) "Synthese und Pharmakologie potenter 5-HT2A-Rezeptoragonisten mit N-2-Methoxybenzyl-Partialstruktur. Entwicklung eines neuen Struktur-Wirkungskonzepts." | http://www.diss.fu-berlin.de/diss/receive/FUDISS_thesis_000000001221 (in German). diss.fu-berlin.de. Retrieved 2013-05-10.
↑Talaie, H., Panahandeh, R., Fayaznouri, M. R., Asadi, Z., & Abdollahi, M. (2009). Dose-independent occurrence of seizure with tramadol. Journal of medical toxicology, 5(2), 63-67. doi:10.1007/BF03161089
↑Noteikumi par Latvijā kontrolējamajām narkotiskajām vielām, psihotropajām vielām un prekursoriem (2,5-Dimetoksifeniletānamīni) | http://likumi.lv/doc.php?id=121086
