Salvinorin B methoxymethyl ether: Difference between revisions
>Dextromethorphan No edit summary |
>White Summarysheet template added |
||
| Line 6: | Line 6: | ||
{{proofread}} | {{proofread}} | ||
|} | |} | ||
{{SummarySheet}} | |||
{{SubstanceBox/Salvinorin B}} | {{SubstanceBox/Salvinorin B}} | ||
'''Salvinorin B methoxymethyl ether''' (2-O-methoxymethylsalvinorin B) is a semi-synthetic analogue of the natural product [[Salvinorin A]] which is used in scientific research. It has a longer duration of action of around 2–3 hours, compared to less than 30 minutes for salvinorin A, and has increased affinity and potency at the κ-opioid receptor. Like the related compound herkinorin, salvinorin B methoxymethyl ether is made from salvinorin B, which is most conveniently made from salvinorin A by deacetylation, as while both salvinorin A and salvinorin B are found in the plant Salvia divinorum, salvinorin A is present in larger quantities. | '''Salvinorin B methoxymethyl ether''' (2-O-methoxymethylsalvinorin B) is a semi-synthetic analogue of the natural product [[Salvinorin A]] which is used in scientific research. It has a longer duration of action of around 2–3 hours, compared to less than 30 minutes for salvinorin A, and has increased affinity and potency at the κ-opioid receptor. Like the related compound herkinorin, salvinorin B methoxymethyl ether is made from salvinorin B, which is most conveniently made from salvinorin A by deacetylation, as while both salvinorin A and salvinorin B are found in the plant Salvia divinorum, salvinorin A is present in larger quantities. | ||
Revision as of 18:59, 14 June 2017
|
| Summary sheet: Salvinorin B methoxymethyl ether |
Template:SubstanceBox/Salvinorin B
Salvinorin B methoxymethyl ether (2-O-methoxymethylsalvinorin B) is a semi-synthetic analogue of the natural product Salvinorin A which is used in scientific research. It has a longer duration of action of around 2–3 hours, compared to less than 30 minutes for salvinorin A, and has increased affinity and potency at the κ-opioid receptor. Like the related compound herkinorin, salvinorin B methoxymethyl ether is made from salvinorin B, which is most conveniently made from salvinorin A by deacetylation, as while both salvinorin A and salvinorin B are found in the plant Salvia divinorum, salvinorin A is present in larger quantities.
Salvinorin B methoxymethyl ether has a Ki of 0.60 nM at the κ opioid receptor, and is around five times more potent than salvinorin A in animal studies, although it is still only half as potent as its stronger homolog salvinorin B ethoxymethyl ether.