25N-NBOMe

Members of the NBOMe series have been linked to numerous overdoses and fatalities.

It is strongly discouraged to insufflate (snort) or take higher doses of these compounds. Please see this section for more details.

Summary sheet: 25N-NBOMe

25N-NBOMe
Chemical Nomenclature
Common names	25N-NBOMe
Systematic name	2-(2,5-dimethoxy-4-nitrophenyl)-N-(2-methoxybenzyl)ethanamine
Class Membership
Psychoactive class	Psychedelic
Chemical class	Phenethylamine
Routes of Administration
WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section. ⇣ Sublingual Dosage Threshold < 100 µg Light 100 - 300 µg Common 300 - 800 µg Strong 800 - 1300 μg Heavy The NBOMe series can be fatal at heavy doses. Duration Total 5 - 10 hours Onset 45 - 75 minutes Peak 2 - 3 hours Offset 2 - 3 hours After effects 5 - 10 hours ⇣ Insufflated Dosage Heavy The NBOMe series can be fatal when insufflated. It is strongly discouraged. Duration Total 4 - 8 hours DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.
Interactions
2C-T-X
5-MeO-xxt
Caffeine
Cannabis
DOx
MAOIs
MDMA
MXE
Amphetamines
aMT
Cocaine
DXM
Tramadol
Lithium

25N-NBOMe (2C-N-NBOMe) is a derivative of the substituted phenethylamine psychedelic 2C-N, which was discovered in 2004 by Ralf Heim at the Free University of Berlin and subsequently investigated by a team at Purdue University led by David E. Nichols.

25N-NBOMe has a notably shorter duration than the rest of the 25x-NBOMe series with a total duration of 6 hours and a peak duration of 2 hours. It is moderately active at a dose of one milligram, and two milligrams provide a strong/heavy trip. This substance is considerably less potent when compared to the more popular NBOMe compunds such as 25B-NBOMe, 25I-NBOMe and 25C-NBOMe, all which lead to strong trips at 1mg+ doses.

Chemistry

25N-NBOMe or 2C-N-NBOMe is a serotonergic N-benzyl derivative of the substituted phenethylamine psychedelic known as 2C-N. 25N-NBOMe is a substituted phenethylamine with methoxy groups CH₃O- attached to carbons R₂ and R₅ as well as a nitro group NO₂- attached to carbon R₄. It differs from 2C-N structurally through a substitution on the amine (NH₂) with a 2-methoxybenzyl (BOMe) group as shown in the image to the right. 25N-NBOMe shares this 2-methoxybenzyl substitution with other chemicals of the NBOMe family. This NBOMe addition contains a methoxy ether CH₃O- bound to a benzene ring at R₂.

Pharmacology

Further information: Serotonergic psychedelic

25N-NBOMe likely has efficacy at the 5-HT_2A receptor where it is assumed to act as a partial agonist. However, the role of these interactions and how they result in the psychedelic experience continues to remain elusive.

There is insufficient scientific research to determine this compound's true nature as the pharmacological properties of 25N-NBOMe have not been described in the scientific literature, but only in anecdotal reports.

Subjective effects

The effects listed below are based upon the subjective effects index and personal experiences of PsychonautWiki contributors. The listed effects will rarely (if ever) occur all at once, but heavier dosages will increase the chances and are more likely to induce a full range of effects.

Physical effects

• Bodily control enhancement - When combined with stimulation, this component manifests as a strong drive to partake in physical activities.
• Increased heart rate
• Nausea - Users (especially those prone to it) may experience nausea during the come up. The nausea will subside over the peak.
• Pupil dilation
• Runny nose - 25N-NBOMe may cause a runny nose and increased mucus production in some users.
• Stimulation - In terms of its effects on the energy levels of the tripper, 25N-NBOMe is quite stimulating, and leftover stimulation can linger up to 10 hours even after the trip subsides.
• Tactile enhancement
• Vasoconstriction
• Wakefulness

Cognitive effects

The cognitive effects of 25N-NBOMe can be described as quite reminiscent to that of 25C-NBOMe. They can be broken down into several components which progressively intensify proportional to dosage. These are described below and generally include:

• Analysis enhancement - This component is introspection dominant.
• Conceptual thinking
• Emotionality enhancement
• Perception of self-design
• Increased music appreciation
• Laughter
• Memory suppression
  • Ego death
• Novelty enhancement
• Thought connectivity
• Time distortion
• Wakefulness

Visual effects

Enhancements

• Visual acuity enhancement
• Colour enhancement
• Pattern recognition enhancement

Distortions

• Drifting (melting, flowing, breathing and morphing) - In comparison to other psychedelics, this effect can be described as highly detailed, slow and smooth in motion, static in appearance and unrealistic/cartoon-like in style.
• Symmetrical texture repetition

Geometry

The visual geometry that is present throughout this trip is often described as similar in appearance to that of LSD. It can be comprehensively described as algorithmic in style, intricate in complexity, fine and zoomed out in detail, fast and smooth in motion, structured in shape, colourful in scheme, glossy in colour, sharp around its edges and mostly rounded across its corners.

In terms of its behaviour, 25N-NBOMe’s geometry leads onto level 8A visual geometry with level 8B remaining so far unconfirmed within this substance. It also seems to consistently build up in visual intensity when the tripper stares at a central point. This eventually envelops the visual field and creates the sensation that the tripper has broken through into a continuously shifting geometric landscape or structure with a vast sense of physical size attributed to it.

Hallucinatory states

• Transformations
• Internal hallucinations (autonomous entities; settings, sceneries, and landscapes; alterations in perspective and scenarios and plots) - 25N-NBOMe is capable of producing a full range of hallucinatory states within the level 1 - 3 range extremely consistently. Level 4 hallucinatory breakthroughs are reported, but very uncommon and inconsistent in comparison to other more commonly used psychedelics such as psilocin, 2C-E and DMT. This effect is more common within dark environments and can be described as internal in its manifestation, lucid in believability, interactive in style and of no particular theme in content or style.

Auditory effects

• Enhancements
• Distortions
• Hallucinations

Toxicity and harm potential

Further information: Research chemicals § Toxicity and harm potential, and Responsible use § Hallucinogens

The toxicity and long-term health effects of recreational 25N-NBOMe use have not been studied in any scientific context and the exact toxic dosage is unknown. This is because 25N-NBOMe is a research chemical with very little history of human usage. Anecdotal evidence from people within the psychonaut community who have tried 25N-NBOMe suggests that there are no negative health effects attributed to simply trying the drug by itself at low to moderate doses and using it very sparingly (but nothing can be completely guaranteed).

Users should be very careful and consider that ingesting 2mg+ of NBOMe series chemicals have proven fatal in some cases. Although there are no reported deaths caused by 25N-NBOMe at this time, it is a rare research chemical with very little history of human usage and is therefore potentially fatal at heavy dosages.

It is strongly recommended that one use harm reduction practices when using this drug.

Tolerance and addiction potential

25N-NBOMe is not habit-forming and the desire to use it can actually decrease with use. It is most often self-regulating.

Tolerance to the effects of 25N-NBOMe are built almost immediately after ingestion. After that, it takes about 3 days for the tolerance to be reduced to half and 7 days to be back at baseline (in the absence of further consumption). 25N-NBOMe presents cross-tolerance with [[Cross-tolerance::all psychedelics]], meaning that after the consumption of 25N-NBOMe all psychedelics will have a reduced effect.

Legal issues

• Brazil - Possession, production and sale is illegal as it is listed on Portaria SVS/MS nº 344.
• USA: 25N-NBOMe is unscheduled in the United States. It may be considered an analog of 2C-N (which is a Schedule I drug under the Controlled Substances Act). As such, the sale for human consumption or the use for illicit non-medical or industrial intents and purposes could be prosecuted as crimes under the Federal Analog Act.
• UK: On 10 June 2014, all NBOMes became Class A drugs which means that they’re illegal to have, give away or sell. Possession could get one up to seven years in jail and/or an unlimited fine. Supplying someone else could result in a heavy jail time sentence between a minimum of eight years and a life sentence and/or an unlimited fine.
• Latvia: 25N-NBOMe is a Schedule I controlled substance.

See also

• Responsible use
• Psychedelic
• Stimulant
• 25B-NBOMe
• 25C-NBOMe
• 25I-NBOMe

External links

• 25N-NBOMe (Wikipedia)
• 25N-NBOMe (Bluelight)
• 25N-NBOMe (Tripsit)