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'''4-Acetoxy-N,N-diisopropyltryptamine''' (also known as '''4-AcO-DiPT''', '''4-Acetoxy-DiPT''', '''Ipracetin''' and colloquially as '''"Aces"'''<ref>Erowid. (n.d.). Erowid 4-Acetoxy-DiPT Vault. Retrieved from https://erowid.org/chemicals/4_acetoxy_dipt/4_acetoxy_dipt.shtml</ref>) is a lesser-known synthetic [[psychoactive class::psychedelic]] substance of the [[chemical class::tryptamine]] chemical class that reportedly produces a unique mixture of physically-oriented, [[stimulating]], and minimally [[Visual effects - Psychedelics|visual]] and [[introspection|introspective]] psychedelic effects when [[Routes of administration|administered]]. It has been described in early online reports as being only vaguely similar in nature to chemically-related tryptamine substances such as [[psilocin]] or [[4-AcO-DMT]] but with the [[Disinhibition|disinhibiting]], [[Euphoria|physically euphoric]] and [[Increased libido|libidinous]] signature of psychedelics like [[5-MeO-MiPT]], and curiously short duration of around 2.5 - 4 hours. It has since been reported to be slightly longer lasting and less potent than [[4-HO-DiPT]] (also known as '''Iprocin''') with an active dose reported as being between 15 and 40 mg.<ref name="Primer">Erowid. (1999, November). Erowid 4-Acetoxy-DiPT Vaults: Primer. Retrieved from https://www.erowid.org/chemicals/4_acetoxy_dipt/4_acetoxy_dipt_primer.shtml</ref>  
'''4-Acetoxy-N,N-diisopropyltryptamine''' (also known as '''4-AcO-DiPT''', '''4-Acetoxy-DiPT''', '''Ipracetin''' and colloquially as '''"Aces"'''<ref>Erowid. (n.d.). Erowid 4-Acetoxy-DiPT Vault. Retrieved from https://erowid.org/chemicals/4_acetoxy_dipt/4_acetoxy_dipt.shtml</ref>) is a lesser-known synthetic [[psychoactive class::psychedelic]] substance of the [[chemical class::tryptamine]] chemical class that reportedly produces a unique mixture of physically-oriented, [[stimulating]], and minimally [[Visual effects - Psychedelics|visual]] and [[introspection|introspective]] psychedelic effects when [[Routes of administration|administered]]. It has been described in early online reports as being only vaguely similar in nature to chemically-related tryptamine substances such as [[psilocin]] or [[4-AcO-DMT]] but with the [[Disinhibition|disinhibiting]], [[Euphoria|physically euphoric]] and [[Increased libido|libidinous]] signature of psychedelics like [[5-MeO-MiPT]], and an oddly short duration of around 3 - 4 hours. It has since been reported to be slightly longer lasting and mildly less potent than [[4-HO-DiPT]] (also known as '''Iprocin''') with an active dose reported as being between 15 and 40 mg.<ref name="Primer">Erowid. (1999, November). Erowid 4-Acetoxy-DiPT Vaults: Primer. Retrieved from https://www.erowid.org/chemicals/4_acetoxy_dipt/4_acetoxy_dipt_primer.shtml</ref>  


4-AcO-DiPT is primarily thought to act as a [[prodrug]] to [[4-HO-DiPT]], of which [[Alexander Shulgin]] comments on in his book [[TiHKAL]] ("Tryptamines I Have Known and Loved") that he "truly doubt(s) that there is another psychedelic drug, anywhere, that can match this one for speed, for intensity, for brevity, and sensitive to dose, at least one that is active orally."<ref name="tihkalweb17">Shulgin, A., & Shulgin, A. (1991). [https://www.erowid.org/library/books_online/tihkal/tihkal17.shtml Erowid Online Books: "TIHKAL" - #17. 4-HO-DIPT]. Retrieved May 2, 2017.</ref> Anecdotal reports dating from at least 1999 reveals that these properties are largely preserved in 4-AcO-DiPT, with the exception of a less rapid onset, slightly extended duration and less physical side-effects from the over-stimulation [[4-HO-DiPT]] is known to produce, making it a more comfortable experience overall.<ref name="Primer" /> However, due to its relatively short history of human use and lack of any scientific studies, its toxicity profile is unknown and users are advised to proceed with caution when experimenting with this substance.
4-AcO-DiPT is primarily thought to act as a [[prodrug]] to [[4-HO-DiPT]], a substance which [[Alexander Shulgin]] comments on in his book [[TiHKAL]] ("Tryptamines I Have Known and Loved"). Of it he writes that he "truly doubt(s) that there is another psychedelic drug, anywhere, that can match this one for speed, for intensity, for brevity, and sensitive to dose, at least one that is active orally."<ref name="tihkalweb17">Shulgin, A., & Shulgin, A. (1991). [https://www.erowid.org/library/books_online/tihkal/tihkal17.shtml Erowid Online Books: "TIHKAL" - #17. 4-HO-DIPT]. Retrieved May 2, 2017.</ref> Anecdotal reports dating from at least 1999 reveals that these properties are largely preserved with 4-AcO-DiPT, with the exception of a less rapid and potentially jarring onset, slightly extended duration and decreased physical side-effects from the over-stimulation that [[4-HO-DiPT]] has the tendency to produce, making it a more comfortable experience overall.<ref name="Primer" /> However, due to its relatively short history of human use and lack of any scientific studies, its toxicity profile is unknown and users are advised to proceed with caution when experimenting with this substance.


Today, 4-AcO-DiPT is rarely made available on the market and when it is, is almost exclusively distributed online as a gray-area [[research chemical]] for [[entheogenic]] and [[recreational drug use|recreational purposes]]. It is an example of the early wave of psychedelic [[research chemical]] that were explored following the wake of its initial synthesis and documentation in [[TiHKAL]], before the emergence of an easily-accessible internet vendor network of [[psychedelic]] research chemicals in the early 2000s, where it has persisted ever since.{{citation needed}}
Today, 4-AcO-DiPT is rarely made available on the market and when it is, is almost exclusively distributed online as a gray-area [[research chemical]] for [[entheogenic]] and [[recreational drug use|recreational purposes]]. It is an example of the early wave of psychedelic [[research chemical]] that were explored following the wake of its initial synthesis and documentation in [[TiHKAL]], before the emergence of an easily-accessible internet vendor network of [[psychedelic]] research chemicals in the early 2000s, which has persisted ever since.{{citation needed}}
   
   
==Chemistry==
==Chemistry==

Revision as of 23:13, 2 May 2017

4-AcO-DiPT
Chemical Nomenclature
Common names 4-AcO-DiPT, 4-Acetoxy-DiPT, Ipracetin, Aces
Substitutive name 4-Acetoxy-N,N-diisopropyltryptamine
Systematic name 3-[2-(Diisopropylamino)ethyl]-1H-indol-4-yl acetate
Class Membership
Psychoactive class Psychedelic
Chemical class Tryptamine
Routes of Administration

WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section.



⇣ Oral
Dosage
Threshold 3 mg
Light 5 - 15 mg
Common 15 - 30 mg
Strong 30 - 45 mg
Heavy 45 mg +
Duration
Total 3 - 4 hours
Onset 15 - 40 minutes
Come up 20 - 40 minutes
Peak 1.5 - 2 hours
Offset 1 - 1.5 hours
After effects 2 - 6 hours









DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.

Interactions
Summary sheet: 4-AcO-DiPT

4-Acetoxy-N,N-diisopropyltryptamine (also known as 4-AcO-DiPT, 4-Acetoxy-DiPT, Ipracetin and colloquially as "Aces"[1]) is a lesser-known synthetic psychedelic substance of the tryptamine chemical class that reportedly produces a unique mixture of physically-oriented, stimulating, and minimally visual and introspective psychedelic effects when administered. It has been described in early online reports as being only vaguely similar in nature to chemically-related tryptamine substances such as psilocin or 4-AcO-DMT but with the disinhibiting, physically euphoric and libidinous signature of psychedelics like 5-MeO-MiPT, and an oddly short duration of around 3 - 4 hours. It has since been reported to be slightly longer lasting and mildly less potent than 4-HO-DiPT (also known as Iprocin) with an active dose reported as being between 15 and 40 mg.[2]

4-AcO-DiPT is primarily thought to act as a prodrug to 4-HO-DiPT, a substance which Alexander Shulgin comments on in his book TiHKAL ("Tryptamines I Have Known and Loved"). Of it he writes that he "truly doubt(s) that there is another psychedelic drug, anywhere, that can match this one for speed, for intensity, for brevity, and sensitive to dose, at least one that is active orally."[3] Anecdotal reports dating from at least 1999 reveals that these properties are largely preserved with 4-AcO-DiPT, with the exception of a less rapid and potentially jarring onset, slightly extended duration and decreased physical side-effects from the over-stimulation that 4-HO-DiPT has the tendency to produce, making it a more comfortable experience overall.[2] However, due to its relatively short history of human use and lack of any scientific studies, its toxicity profile is unknown and users are advised to proceed with caution when experimenting with this substance.

Today, 4-AcO-DiPT is rarely made available on the market and when it is, is almost exclusively distributed online as a gray-area research chemical for entheogenic and recreational purposes. It is an example of the early wave of psychedelic research chemical that were explored following the wake of its initial synthesis and documentation in TiHKAL, before the emergence of an easily-accessible internet vendor network of psychedelic research chemicals in the early 2000s, which has persisted ever since.[citation needed]

Chemistry

4-Acetoxy-N,N-diisopropyltryptamine, or 4-AcO-DiPT, is a synthetic indole alkaloid molecule of the tryptamine chemical class. Tryptamines share a core structure comprised of a bicylic indole heterocycle attached at R3 to an amino group via an ethyl side chain. 4-AcO-DiPT is substituted at R4 of its indole heterocycle with an acetoxy (-AcO) functional group CH3COO−. It also contains two diisopropyl chains bound to the terminal amine RN of its base tryptamine backbone (i.e. DiPT).

4-AcO-DiPT is the N-substituted isopropyl homolog of 4-HO-DMT (Psilocin), the acetate ester analog of DiPT and the N-substituted diisopropyl analog of 4-AcO-DMT.[4]

Pharmacology

Further information: Serotonergic psychedelic

4-AcO-DiPT likely acts as a 5-HT2A partial agonist. The primary psychedelic effects are believed to come from 4-AcO-DiPT's efficacy at the 5-HT2A receptors, although a number of other receptors may be involved as well. However, the role of these interactions and how they result in the psychedelic experience remains subject to ongoing scientific investigation.

It is worth noting that 4-AcO-DiPT is reported to produce effects that are almost identical to its 4-HO-DiPT counterpart, albeit with a slightly extended duration and slower ramp-up in its activity.[2] This is in the same manner that 4-AcO-DMT/4-HO-DMT, 4-AcO-MET/4-HO-MET, and 4-AcO-DET/4-HO-DMT all share the core phenomenology to their counterparts, suggesting that the 4-acetoxy tryptamine compounds are largely deacetylated into their respective 4-hydroxy analogs before exerting their main effects, though the degree and manner to which this occurs has yet to be scientifically elucidated.

Subjective effects

Disclaimer: The effects listed below cite the Subjective Effect Index (SEI), an open research literature based on anecdotal user reports and the personal analyses of PsychonautWiki contributors. As a result, they should be viewed with a healthy degree of skepticism.

It is also worth noting that these effects will not necessarily occur in a predictable or reliable manner, although higher doses are more liable to induce the full spectrum of effects. Likewise, adverse effects become increasingly likely with higher doses and may include addiction, severe injury, or death ☠.

Physical effects

The physical effects of 4-AcO-DiPT are perhaps the most pronounced and distinct of any four-position substituted tryptamine. Anecdotal reports suggest that they seem to come at the expense of any introspective quality and instead produces a state marked initially by sedation, deep relaxation, and physical comfort before proceeding to a state marked by a unique sense of psychedelic-type stimulation, tactile enhancements and physical euphoria that remains consistent throughout the experience.

  • Spontaneous tactile sensations - The "body high" of 4-AcO-DiPT can be described as a pleasurable, soft and all-encompassing tingling sensation or glow. This maintains a consistent presence that steadily rises with the onset and hits its limit once the peak has been reached. Once the peak of the experience or sensation is reached it can feel writhingly euphoric and tranquil along with a paradoxical sense of energetic stimulation that is considered to be atypical for a substituted tryptamine.
    • Physical euphoria - It should be noted that this effect is a very consistent and predominating component relative to related psychedelics like psilocin and produces energetic and stimulating effects that uniquely resemble those produced by stimulants or entactogens (in as close as a psychedelic can get to the physical euphoria these substances can produce), albeit in a less forced manner.
  • Tactile enhancement - This effect is extremely prominent relative to just about all other substituted tryptamines.
  • Sedation and Stimulation - In terms of its effects on the physical energy levels of the tripper, 4-AcO-DiPT is considered have the paradoxical property of both being relaxing, stoning and mildly sedating that arises in the first part of the experience, before the development of a marked sense of physical stimulation that can promote energetic activities such as dancing.
  • Perception of increased weight- This effect corresponds to the general sense of sedation and relaxation that characterizes 4-AcO-DiPT experiences, this manifests as a bodily heaviness that discourages movement but is typically only prominent during the first half of the trip.
  • Changes in felt bodily form - This effect is often accompanied by a sense of warmth or unity and usually occurs during the initial part of the experience before the stimulating effects become more prominent. Users can feel as if they are physically part of or conjoined with other objects. This is usually reported as feeling deeply comfortable in its sensations and even peaceful, and is a very prominent effect produced by 4-HO-DiPT.
  • Muscle relaxation
  • Nausea - This effect can be greatly lessened or even completely avoided if the individual has an empty stomach prior to ingestion. It is often recommended that one either refrain from eating for approximately 6 to 8 hours beforehand, or eat a light meal 3 to 4 hours before if they are feeling physically fatigued. Relative to other tryptamines like psilocybin mushrooms or 4-AcO-DMT, there is minimal to no nausea that is produced by this substance.
  • Temperature regulation suppression - A special amount of attention should be paid to the temperature modulating effects of this compound -- especially at its peak -- as reports suggest that it can reliably produce increased bodily temperature that is somewhat atypical for a substituted tryptamine.
  • Increased heart rate
  • Restless leg syndrome
  • Excessive yawning
  • Muscle contractions
  • Watery eyes
  • Pupil dilation
  • Seizure - This is a very rare effect but can likely happen in those predisposed to them, especially while in physically taxing conditions such as being dehydrated, fatigued or undernourished.

Cognitive effects

The cognitive effects of 4-AcO-DiPT are described by many as a paradoxical mixture of being both sedating/stoning and markedly stimulating in style when compared to other commonly used tryptamines such as psilocin or 4-AcO-DMT, which tend to be sedating, introspective, and personally meaningful. It is also regarded as being notably more lucid and un-impairing than psilocybin mushrooms or even LSD, with minimal to no headspace or visual alterations. It displays a number of cognitive effects that are not typically associated with traditional serotonergic psychedelics.

The most prominent of these typical effects generally include:

  • Disinhibition - This effect is notably pronounced for a psychedelic and lends to increased sociability and pleasure-seeking behavior.
  • Increased music appreciation
  • Novelty enhancement
  • Immersion enhancement
  • Compulsive redosing - This effect seems very pronounced and unique for this substance compared to traditional psychedelics, and is likely due to thcombined with an atypically short duration marked by a rapid come up followed by an equally rapid offset.
  • Outrospection - This substance has been reported as being atypically non-introspective for a psychedelic tryptamine, instead lending itself to social activities and recreational outings.
  • Empathy, love, and sociability enhancement - This effect can be described as being less prominent, consistent and profound when compared to other traditional psychedelics such as mescaline, LSD or 4-AcO-DMT. It can lead to strong feelings of physical connection and social bonding, both in mass gatherings as well as in more intimate settings. The sociability enhancement occurs at a much higher and consistent rate than with just about all other substituted tryptamines, which tend to produce socially-impairing effects at medium-to-high doses that 4-AcO-DiPT does not.
  • Anxiety suppression
  • Ego inflation
  • Mindfulness - This effect is typically only prominent at the very beginning stages of the experience, before the stimulating and disinhibiting aspects take over.
  • Time distortion

Visual effects

In comparison to other psychedelics and substituted tryptamines, 4-AcO-DiPT presents very little in the way of visual effects, with only mild visual alterations even at heavy doses for all of the effects listed across the board. Anecdotal reports suggest that it is incapable of producing any higher level visuals and totally incapable of inducing geometry or hallucinatory states as is the case with other 4-substituted tryptamines such as 4-AcO-DMT or 4-AcO-MET.

Enhancements

Distortions

Auditory effects

Combinational effects

  • Cannabis - When used in conjunction with cannabis, both the visual and cognitive effects of psilocin can be intensified and extended with extreme efficiency. This should be used with extreme caution, especially if one is not experienced with psychedelics. Many users sometimes report a dramatically more intense visual trip when combining it with THC concentrates such as hashish as opposed to cannabis flower; however, this can also amplify the anxiety, confusion and psychosis producing aspects of cannabis significantly, so extreme caution is advised.
  • Dissociatives - When used in combination with dissociatives, the geometry, euphoria, dissociation and hallucinatory effects are often greatly enhanced. Dissociative-induced holes, spaces, and voids while under the influence of psilocin can result in significantly more vivid visuals than dissociatives alone present, along with more intense internal hallucinations, confusion, delusions and chances of a psychotic reaction.
  • MDMA - When used in conjunction with MDMA, the physical and cognitive effects of MDMA are amplified. The visual, physical and cognitive effects of psilocin are also intensified with an overwhelming euphoric pleasure manifested through uniquely pleasurable body highs and headspaces, and uniquely colorful and awe-inspiring visuals. The synergy between these substances is unpredictable, and it is best to start with markedly lower dosages than one would take for both substances individually.
  • Alcohol - This interaction is not typically recommended due to alcohol’s ability to cause dehydration, depression and thought disorganization which can negatively affect a trip if taken in high dosages. This combination is however reasonably safe in low doses and when used responsibly, this can often take the edge off a trip as well as dull its psychedelic effects in a fashion somewhat similar to benzodiazepines, albeit more stressful on the body.
  • Benzodiazepines - When used in combination with benzodiazepines, benzodiazepines can, depending on the dosage, slightly to completely reduce the intensity of the cognitive, physical and visual effects of a psilocin trip. They are very efficient at stopping bad trips at the cost of amnesia and reduced trip intensity. Caution is advised when acquiring them for this purpose, however, due to the very high addiction potential that benzodiazepines possess.

Experience reports

Anecdotal reports which describe the effects of this compound within our experience index include:

Additional experience reports can be found here:

Toxicity and harm potential

Further information: Research chemicals § Toxicity and harm potential, and Responsible use § Hallucinogens

The toxicity and long-term health effects of recreational 4-AcO-DiPT use do not seem to have been studied in any scientific context and the exact toxic dose is unknown. This is because 4-AcO-DiPT is a research chemical with very little history of human usage. Anecdotal evidence from people within the psychonaut community who have tried 4-AcO-DiPT suggests that there are no negative health effects attributed to simply trying the drug by itself at low to moderate doses and using it very sparingly (but nothing can be completely guaranteed). Independent research should always be done to ensure that a combination of two or more substances is safe before consumption.

It is strongly recommended that one use harm reduction practices when using this drug.

Tolerance and addiction potential

4-AcO-DiPT is not habit-forming and the desire to use it can actually decrease with repeatedd use. As with most psychedelics, it is generally considered to have a built-in, self-regulating aspect to it.

Tolerance to the effects of 4-AcO-DiPT are built almost immediately after ingestion. Afterward, it takes about 3 days for the tolerance to be reduced to half and 7 days to be back at baseline (in the absence of further consumption). 4-AcO-DiPT presents cross-tolerance with [[Cross-tolerance::all psychedelics]], meaning that after the consumption of 4-AcO-DiPT all psychedelics will have a reduced effect.

This legality section is a stub.

As such, it may contain incomplete or wrong information. You can help by expanding it.

  • Denmark - 4-AcO-DiPT is a Schedule B controlled substance in Denmark.[5]
  • Japan - 4-AcO-DiPT is a controlled substance in Japan.[6]
  • Sweden - 4-AcO-DiPT is illegal to sell or possess in Sweden.[7]
  • United States - 4-AcO-DiPT is unscheduled in the United States. It may be considered an analogue of psilocin (4-HO-DMT) which is a Schedule I drug under the Controlled Substances Act. As such, the sale for human consumption or the use for illicit non-medical or industrial intents and purposes could be prosecuted as crimes under the Federal Analogue Act.[citation needed]
  • United Kingdom - 4-AcO-DiPT is a Class A drug in the UK as it is an ester of the drug 4-HO-DiPT[8], which is a Class A drug as a result of the tryptamine catch-all clause.[9]

See also

References

  1. ↑ Erowid. (n.d.). Erowid 4-Acetoxy-DiPT Vault. Retrieved from https://erowid.org/chemicals/4_acetoxy_dipt/4_acetoxy_dipt.shtml
  2. ↑ 2.0 2.1 2.2 2.3 2.4 2.5 Erowid. (1999, November). Erowid 4-Acetoxy-DiPT Vaults: Primer. Retrieved from https://www.erowid.org/chemicals/4_acetoxy_dipt/4_acetoxy_dipt_primer.shtml
  3. ↑ Shulgin, A., & Shulgin, A. (1991). Erowid Online Books: "TIHKAL" - #17. 4-HO-DIPT. Retrieved May 2, 2017.
  4. ↑ National Center for Biotechnology Information. PubChem Compound Database; CID=24801868, https://pubchem.ncbi.nlm.nih.gov/compound/24801868 (accessed May 2, 2017).
  5. ↑ https://www.retsinformation.dk/Forms/R0710.aspx?id=137169
  6. ↑ ホーム > 政策について > 分野別の政策一覧 > 健康・医療 > 医薬品・医療機器 > 薬物乱用防止に関する情報 | http://www.mhlw.go.jp/bunya/iyakuhin/yakubuturanyou/scheduled-drug/list.html
  7. ↑ Svensk författningssamling | http://www.notisum.se/rnp/sls/sfs/20050026.pdf
  8. ↑ Misuse of Drugs Act 1971 (Legislation.gov.uk) | http://www.legislation.gov.uk/ukpga/1971/38/schedule/2/part/I/paragraph/3
  9. ↑ Misuse of Drugs Act 1971 (Legislation.gov.uk) |http://www.legislation.gov.uk/ukpga/1971/38/schedule/2/part/I#reference-M_F_c7632653-ddad-4420-f307-e3da1e36d30e


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