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| | {{Template:Warning/3-HO-PCE}}
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| {{SubstanceBox/3-HO-PCE}}
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| | ''[[3-HO-PCE/Summary|Summary sheet: 3-HO-PCE]]''
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| '''3-Hydroxyeticyclidine''' ('''3-HO-PCE''') is a novel [[psychoactive class::dissociative]] substance of the [[chemical class::arylcyclohexylamine]] chemical class that has been reported to produce [[pain relief|anesthetic and anelgesic]] as well as [[hallucinogen]]ic effects. It has been speculated to be extremely potent with a dosage range of 0.5-2mg and is structurally related to [[3-MeO-PCE]] and [[3-HO-PCP]].
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| This compound induces a state referred to as "[[dissociative#subjective effects|dissociative anesthesia]]" when ingested.
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| Early reports indicate that 3-HO-PCE shares similar properties to that of [[3-HO-PCP]] and to a lesser extent, 3-MeO-PCE and 3-MeO-PCP.<ref>From PCP to MXE: a comprehensive review of the non-medical use of dissociative drugs | http://onlinelibrary.wiley.com/doi/10.1002/dta.1620/abstract</ref>, but with what seems to be a moderately higher risk of inducing states of [[delusions]], [[mania]] and [[psychosis]]{{citation needed}}. Because of this, it is highly recommended to use [[responsible drug use]] practices when using this substance such as using a [[milligram scale]] (and preferably [[volumetric liquid dosing]]) as well as having a sober [[trip sitter]] present throughout the experience.
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| 3-HO-PCE has recently become accessible through online [[research chemical]] vendors<ref name="one">3-HO-PCE (BlueLight) | http://www.bluelight.org/vb/threads/632323-3-ho-pce</ref> where it is being sold as a [[designer drug]] replacement for [[MXE]] and other designer dissociatives.
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| ==Chemistry==
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| [[File:Ach base.png|thumb|150px|right|Generic structure of arylcyclohexylamine molecule]]
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| {{chemistry}}
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| ==Pharmacology==
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| {{Further|NMDA receptor antagonist}}
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| Due to the lack of research regarding the substance, all discussion regarding the pharmacology of it is purely based on its structure and subjective effect similarities to other [[arylcyclohexylamine]] [[dissociative]]s such as [[PCP]] and [[ketamine]]. With this in mind, 3-HO-PCE is thought to act as an [[NMDA receptor antagonist]]. NMDA receptors allow for electrical signals to pass between neurons in the brain and spinal column; for the signals to pass, the receptor must be open. Dissociatives close the NMDA receptors by blocking them. This disconnection of neurons leads to loss of feeling, difficulty moving, and eventually this substance's equivalent of the “[[Visual_disconnection#Holes.2C_spaces_and_voids|K-hole]].”
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| ==Subjective effects==
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| {{effectStub}}
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| ==Toxicity and harm potential==
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| {{Further|Research chemicals#Toxicity and harm potential}}
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| The toxicity and long-term health effects of recreational 3-HO-PCE use do not seem to have been studied in any scientific context and the [[Toxicity::exact toxic dosage is unknown]]. This is because 3-HO-PCE has very little history of human usage. Anecdotal evidence from people who have tried 3-HO-PCE within the community suggest that there do not seem to be any negative health effects attributed to simply trying this drug at low to moderate doses by itself and using it sparingly (but nothing can be completely guaranteed).
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| It is strongly recommended that one use [[responsible drug use|harm reduction practices]] when using this drug.
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| ===Psychosis===
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| 3-HO-PCE has been reported to cause [[psychosis]], [[delusions]], and [[mania]] at a significantly higher rate than other [[dissociative]]s such as [[ketamine]], [[diphenidine]], or [[MXE]]. There are a large number of experience reports online which describe states of "psychotic delirium, amnesia, mania, and other serious consequences" after abusing the drug.{{Citation needed}}
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| It is strongly recommended that one use extreme caution and [[responsible drug use|harm reduction]] practices when using this substance.
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| *Users should avoid using the substance multiple days in a row or becoming addicted to it as this increases the risk of severe adverse effects.
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| *The recommended dosage range should not be exceeded as high doses can trigger these effects as well.
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| *Users should start with extremely low doses and work their way up as slowly as possible. [[Volumetric liquid dosing|Volumetric liquid dosing]] should preferably be used due to the drug's potency; most standard milligram scales cannot accurately weigh out doses below 10-15mg.<ref>3-MeO-PCE (TripSit) | https://wiki.tripsit.me/wiki/3-MeO-PCE</ref>
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| *[[Compulsive redosing]] before one has fully sobered up is not recommended and can result in too high of a dose.
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| Due to the risk of psychosis, it is not recommended to combine this drug with other substances, especially [[stimulant]]s, [[psychedelic]]s, or other [[dissociative]]s like [[MXE]]. [https://www.google.com/ Independent research] should always be done to ensure that a combination of two or more substances is safe before consumption.
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| It is strongly recommended that one use [[responsible drug use|harm reduction practices]] when using this substance.
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| ===Tolerance and addiction potential===
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| As with other NMDA receptor antagonists, the chronic use of 3-HO-PCE can be considered [[Addiction potential::moderately addictive with a high potential for abuse]] and is capable of causing psychological dependence among certain users. When addiction has developed, cravings and [[withdrawal effects]] may occur if a person suddenly stops their usage.
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| Tolerance to many of the effects of 3-HO-PCE [[Time to full tolerance::develops with prolonged and repeated use]]. This results in users having to administer increasingly large doses to achieve the same effects. After that, it takes about [[Time to half tolerance::3 - 7 days]] for the tolerance to be reduced to half and [[Time to zero tolerance::1 - 2 weeks]] to be back at baseline (in the absence of further consumption). 3-HO-PCE presents cross-tolerance with [[Cross-tolerance::all [[dissociative]]s]], meaning that after the consumption of 3-HO-PCE all [[dissociative]]s will have a reduced effect.
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| ===Urinary tract effects===
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| In terms of its long-term health effects when used repeatedly and with excess for extended periods of time, 3-HO-PCE seems to exhibit almost identical bladder and urinary tract problems to those found within [[ketamine]] but to a lesser extent. This is because 3-HO-PCE is a little more potent than ketamine, meaning that less of the drug needs to be consumed. Symptoms of ketamine-induced cystitis can become extremely serious and can be described as:
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| *'''Urinary frequency''' - Urinary frequency is the need to empty the bladder every few minutes.
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| *'''Urinary urgency''' - This can be described as a sudden, compelling need to urinate.
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| *'''Urinary pressure''' - This is experienced as a constant sensation of fullness in the bladder that is unrelieved by urination.
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| *'''Pelvic and bladder pain''' - Pain can develop suddenly and severely, particularly as the bladder fills with urine.
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| *'''Hematuria''' - Hematuria is visible blood in the urine.
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| *'''Incontinence''' - This is the leakage of urine.
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| All of these, however, can easily be avoided by simply not using 3-HO-PCE on a daily or even weekly basis and manually limiting one's usage of the substance.
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| ===Dangerous interactions===
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| {{DangerousInteractions/Intro}}
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| {{DangerousInteractions/Dissos}}
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| ==Legal issues==
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| {{LegalStub}}
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| *'''United Kingdom''' - 3-HO-PCE is a class B drug in the UK and is illegal to possess, produce, supply, or import. It is likely covered by the arylcyclohexylamine generic clause added to the Misuse of Drugs Act by S.I. 2013/239, which came into effect on the 26th February 2013.<ref>The Misuse of Drugs Act 1971 (Amendment) Order 2013 (Legislation.gov.uk) | http://www.legislation.gov.uk/uksi/2013/239/introduction/made</ref>
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| ==See also==
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| *[[Responsible use]]
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| *[[Research chemical]]
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| *[[Dissociative]]
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| *[[3-MeO-PCE]]
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| *[[2'-Oxo-PCE]]
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| *[[Methoxetamine]]
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| ==External links==
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| *[http://www.bluelight.org/vb/threads/632323-3-HO-PCE 2-Oxo-PCE (Bluelight)]
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| *[http://drugs.tripsit.me/3-HO-PCE 3-HO-PCE (TripSit)]
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| *[https://www.bluelight.org/vb/threads/812314-The-Big-amp-Dandy-3-HO-PCE-Thread?p=13958449&viewfull=1#post13958449 Big and dandy 3-ho-PCE thread (Bluelight)]
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| ==Literature==
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| * Morris, H., & Wallach, J. (2014). From PCP to MXE: A comprehensive review of the non-medical use of dissociative drugs. Drug Testing and Analysis, 6(7–8), 614–632. https://doi.org/10.1002/dta.1620
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| ==References==
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| <references/>
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| [[Category:Psychoactive substance]]
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| [[Category:Research chemical]]
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| [[Category:Arylcyclohexylamine]]
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| [[Category:Dissociative]]
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| {{#set:Featured=true}}
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| == Is there a Discussion section? == | | == Is there a Discussion section? == |
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Is there a Discussion section?
I think a lot of the info on 3-ho-pce has been taken from the info for 3-meo-pce, and I do not believe the information to be correct for 3-ho-pce.
I do not believe it has a strong mOr activity
I do not believe it will cause mania or psychosis in the average person, even used multiple days in a row. In fact, I believe it to be less psychologically harmful than MXE.
regarding dosage. I only have bluelight and tripsit page to offer, and tripsit is easier to read.
The info in the tripsit pages doesn't line up well either, so dosage info from there is way off.
I have only limited research and only a small sample size, but 3-ho-pce seems to be less potent than the tripsit page suggests a strong dose to be 6mg, but in a non-tolerant subject, 3-ho-pce with verified 99.8% purity, it took about 6mg to notice any dissociation. I would like a larger sample size and fewer tolerant people to speak with. In my own experience, even 25mg did not produce any opioid-like feeling. I am, however, somewhat tolerant.
the Bluelight thread starting here starts to give some good info. the dosage info I am reading is making more sense than other posts and matching my own research, with the exception of respiratory depression. In my research, pulsox never went below 94% on a non-tolerant user, bp and hr did not seem to be affected in the healthy particpant (only one). Unlike MXE and other PCE analogs, this does not seem to cause an elevated BP afterwards either.
Also, most positive, there was an afterglow the next day/after the effects had warn off. But unlike MXE, and 2-Oxo-PCE (especially), the test subject didn't complain of any diminished cognitive effects, where he said o-pce and mxe left him feeling a little bit like he was concussed, dizzy, a little strange to talk with. He said that o-pce was the worst of the three, and he preferred the fewer aftereffects of 3-ho-pce to mxe or o-pce. Again, this is HIS experience and anecdotal report he provided to me in a verbal session. I hope more people can get on to testing this.
We have not done many tests just yet, but I hope to do a lot more.
I firmly believe that this is the first true 3-ho-pce on the market, and what was around in 2012-13 was some other, odd (maybe not even an ACH) chem.
