Talk:Doxylamine: Difference between revisions
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Doxylamine is a first generation antihistamine affecting histamine at H1 receptors. In addition, it has powerful anticholinergic effects. | Doxylamine is a first generation antihistamine affecting histamine at H1 receptors. In addition, it has powerful anticholinergic effects. | ||
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Doxylamine is used with pyridoxine to prevent morning sickness. It's also used as a sleep aid useful for alleviating short-term insomnia, and is a useful anti-tussive agent. | Doxylamine is used with pyridoxine to prevent morning sickness. It's also used as a sleep aid useful for alleviating short-term insomnia, and is a useful anti-tussive agent. | ||
'''=== Pharmacology ===''' | |||
Doxylamine is a part of the ethenolamine class of antihistamines. It has powerful anti-allergenic effects, more so than any other antihistamine available over the counter, except for diphenhydramine. | |||
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For healthy adults, doxylamine is usually safe. The LD/50 is around 50-500mg/kg in humans. The IARC has concluded that carcinogenic effects in humans are not a high risk factor. | For healthy adults, doxylamine is usually safe. The LD/50 is around 50-500mg/kg in humans. The IARC has concluded that carcinogenic effects in humans are not a high risk factor. | ||
=== '''Subjective Effects'''=== | |||
'''==== Visual ====''' | |||
* [[Shadow people]] | |||
* [[Unspeakable horrors]] | |||
* [[External hallucinations]] | |||
==== '''Physical''' ==== | |||
* [[Dehydration]] | |||
* [[Physical fatigue]] | |||
* [[Difficulty urinating]] | |||
Revision as of 00:08, 31 March 2017
Doxylamine is a first generation antihistamine affecting histamine at H1 receptors. In addition, it has powerful anticholinergic effects.
Medical Uses
Doxylamine is used with pyridoxine to prevent morning sickness. It's also used as a sleep aid useful for alleviating short-term insomnia, and is a useful anti-tussive agent.
=== Pharmacology ===
Doxylamine is a part of the ethenolamine class of antihistamines. It has powerful anti-allergenic effects, more so than any other antihistamine available over the counter, except for diphenhydramine.
Metabolites
The primary metabolites of doxylamine are-
- N-desmethyldoxylamine
- N,N-didesmethyldoxylamine
- doxylamine N-oxide
Side Effects
- Ataxia
- Dry mouth
- Urinary Retention
- Short-term Memory Failure
- Inability to Concentrate
- Hallucinations
Toxicity
For healthy adults, doxylamine is usually safe. The LD/50 is around 50-500mg/kg in humans. The IARC has concluded that carcinogenic effects in humans are not a high risk factor.
Subjective Effects
==== Visual ====
Physical
References
http://www.inchem.org/documents/iarc/vol79/79-05.html
https://www.ncbi.nlm.nih.gov/pubmed/1975634
https://toxnet.nlm.nih.gov/cgi-bin/sis/search/a?dbs+hsdb:@term+@DOCNO+5184