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==Pharmacology==
==Pharmacology==
The pharmacology of dextrorphan is similar to that of dextromethorphan (DXM). However, dextrorphan is much more potent as an [[NMDA receptor antagonist]] as well as essentially inactive as a [[serotonin]] [[reuptake inhibitor]].<ref>Psychotropic Effects of Dextromethorphan Are Altered by the CYP2D6 Polymorphism: A Pilot Study [http://journals.lww.com/psychopharmacology/pages/articleviewer.aspx?year=1998&issue=08000&article=00014&type=abstract]</ref>
The pharmacology of dextrorphan is similar to that of dextromethorphan (DXM). However, dextrorphan is much more potent as an [[NMDA receptor antagonist]] as well as essentially inactive as a [[serotonin]] [[reuptake inhibitor]].<ref>Psychotropic Effects of Dextromethorphan Are Altered by the CYP2D6 Polymorphism: A Pilot Study [http://journals.lww.com/psychopharmacology/pages/articleviewer.aspx?year=1998&issue=08000&article=00014&type=abstract]</ref>
===Binding affinities (K<sub>i</sub>)===
* NMDA antagonist - 486 nM
* Sigma-1 agonist - 351 nM
* Serotonin transporter (SERT) - 484 nM
* Mu opioid agonist - 420 nM


==Subjective effects==
==Subjective effects==

Revision as of 21:56, 29 March 2017

Most of the first paragraph should be moved to a chemistry section. Please discuss the substance and noteworthy facts in the leading paragraphs.

This article is a stub.

As such, it may contain incomplete or wrong information. You can help by expanding it.

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Dextrorphan
Chemical Nomenclature
Common names DXO
Substitutive name Dextrorphan
Systematic name (+)-17-methyl-9a,13a,14a-morphinan-3-ol
Class Membership
Psychoactive class Dissociative
Chemical class Morphinan
Routes of Administration

WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section.



⇣ Oral
Dosage
Threshold 80 mg
Light 100 - 150 mg
Common 150 - 300 mg
Strong 300 - 450 mg
Heavy 450 mg+
Duration









DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.

Interactions
Benzodiazepines
Cannabis
DOx
25x-NBOMe
2C-T-x
5-MeO-xxT
Amphetamines
Bupropion
Cocaine
ΑMT
PCP
MDMA
Alcohol
GHB
GBL
Opioids
Tramadol
MAOIs
SSRIs
Antihistamines

Dextrorphan (also known as DXO) is a dissociative drug of the morphinan class. It's the main active metabolite of dextromethorphan (DXM). It appears as a colorless powder.[1]

Chemistry

DXM is metabolized in the body by o-demethylation through the CYP2D6 enzyme to form DXO.[2] Both are active chemicals and contribute to the subjective effects experienced when active doses of DXM are consumed.[3]

Pharmacology

The pharmacology of dextrorphan is similar to that of dextromethorphan (DXM). However, dextrorphan is much more potent as an NMDA receptor antagonist as well as essentially inactive as a serotonin reuptake inhibitor.[4]

Binding affinities (Ki)

  • NMDA antagonist - 486 nM
  • Sigma-1 agonist - 351 nM
  • Serotonin transporter (SERT) - 484 nM
  • Mu opioid agonist - 420 nM

Subjective effects

Disclaimer: The effects listed below cite the Subjective Effect Index (SEI), an open research literature based on anecdotal user reports and the personal analyses of PsychonautWiki contributors. As a result, they should be viewed with a healthy degree of skepticism.

It is also worth noting that these effects will not necessarily occur in a predictable or reliable manner, although higher doses are more liable to induce the full spectrum of effects. Likewise, adverse effects become increasingly likely with higher doses and may include addiction, severe injury, or death ☠.

One user reported excessive itchiness accompanied by a "peaceful yet emotionless state" after 340mg of the substance was consumed.[5]

Physical effects

Cognitive effects

  • Germany: Not controlled
  • Poland: Unscheduled[6]
  • United States: Unscheduled since October 1, 1976.[7]

See also

References

  1. ↑ "Erowid DXM Vault : An Unpleasant Exploration of DXO, by Student." Erowid DXM Vault : An Unpleasant Exploration of DXO, by Student. Erowid.org, 15 Sept. 2001. Web. 15 Apr. 2015 [1]
  2. ↑ Cytochrome P450-dependent metabolism of dextromethorphan: fetal and adult studies. [2]
  3. ↑ Dextromethorphan: An update on its utility for neurological and neuropsychiatric disorders - 3. Pharmacodynamics (January 2016)[3]
  4. ↑ Psychotropic Effects of Dextromethorphan Are Altered by the CYP2D6 Polymorphism: A Pilot Study [4]
  5. ↑ "Erowid DXM Vault : An Unpleasant Exploration of DXO, by Student." Erowid DXM Vault : An Unpleasant Exploration of DXO, by Student. Erowid.org, 15 Sept. 2001. Web. 15 Apr. 2015 [5]
  6. ↑ List of scheduled substances in Poland. [6]
  7. ↑ DEA: "Lists of: Scheduling Actions Controlled Substances Regulated Chemicals"
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