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4-HO-DPT: Difference between revisions

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>Kenan
m Text replacement - "The effects listed below are based upon the subjective effects index and personal experiences of PsychonautWiki contributors. The listed effects will rarely (if ever) occur all at once, but heavier dosages will increase the chances and are more likely to induce a full range of effects." to "{{Preamble/SubjectiveEffects}}"
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'''4-HO-DPT''' (also known as '''4-hydroxy-dipropyltryptamine''') is a [[hallucinogen]]ic [[psychoactive class::psychedelic]] drug of the [[chemical class::tryptamine]] class.  
'''4-HO-DPT''' (also known as '''4-hydroxy-dipropyltryptamine''') is a [[hallucinogen]]ic [[psychoactive class::psychedelic]] drug of the [[chemical class::tryptamine]] class. Alexander Shulgin first synthesized 4-HO-DPT and documented it in his book [[TiHKAL]] (''Tryptamines I Have Known and Loved''). It is the 4-hydroxyl analog of [[DPT]].<ref>https://www.erowid.org/library/books_online/tihkal/tihkal20.shtml</ref>
 
Alexander Shulgin first synthesized 4-HO-DPT and documented it in his book [[TiHKAL]] (''Tryptamines I Have Known and Loved''). It is the 4-hydroxyl analog of [[DPT]].<ref>https://www.erowid.org/library/books_online/tihkal/tihkal20.shtml</ref>.


Today it is either used recreationally or as an [[entheogen]]ic compound and is typically acquired through the use of online [[research chemical]] vendors. Due to the difficulty of its synthesis, it remains relatively uncommon even for a substituted tryptamine and has very little history of human usage.
Today it is either used recreationally or as an [[entheogen]]ic compound and is typically acquired through the use of online [[research chemical]] vendors. Due to the difficulty of its synthesis, it remains relatively uncommon even for a substituted tryptamine and has very little history of human usage.
==Chemistry==
==Chemistry==
4-HO-DPT, or 4-hydroxy-N,N-dipropyltryptamine, is a synthetic indole molecule of the [[tryptamine]] class. Tryptamines share a core structure comprised of a bicyclic indole heterocycle attached at R<sub>3</sub> to an amino group via an ethyl side chain. 4-HO-DPT is substituted at R<sub>4</sub> of its indole heterocycle with a hydroxyl functional group OH−. It also contains two propyl chains bound to the terminal amine R<sub>N</sub> of its tryptamine backbone ([[DPT]]).  
4-HO-DPT, or 4-hydroxy-N,N-dipropyltryptamine, is a synthetic indole molecule of the [[tryptamine]] class. Tryptamines share a core structure comprised of a bicyclic indole heterocycle attached at R<sub>3</sub> to an amino group via an ethyl side chain. 4-HO-DPT is substituted at R<sub>4</sub> of its indole heterocycle with a hydroxyl functional group OH−. It also contains two propyl chains bound to the terminal amine R<sub>N</sub> of its tryptamine backbone ([[DPT]]).  
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{{Preamble/SubjectiveEffects}}
{{Preamble/SubjectiveEffects}}


In comparison to other [[tryptamine]]s such as [[4-AcO-DMT]] and [[4-HO-DMT]] it is extremely similar in terms of its visual, cognitive and physical effects although it feels somewhat less natural and slightly more synthetic. It is also worth noting that it lacks the extremely uncomfortable physical side effects which are present within its close structural relative [[DPT]]. This allows it to feel far more similar to that of a generic or classical substituted tryptamine such as [[psilocin]].  
In comparison to other [[tryptamine]]s such as [[4-AcO-DMT]] and [[4-HO-DMT]], it is extremely similar in terms of its visual, cognitive and physical effects although it feels somewhat less natural and slightly more synthetic. It is also worth noting that it lacks the extremely uncomfortable physical side effects which are present within its close structural relative [[DPT]]. This allows it to feel far more similar to that of a generic or classical substituted tryptamine such as [[psilocin]].  
===Physical effects===
===Physical effects===
*'''[[Effect::Spontaneous tactile sensations]]'''
*'''[[Effect::Spontaneous tactile sensations]]'''
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===Tolerance and addiction potential===
===Tolerance and addiction potential===
4-HO-DPT is [[Addiction potential::not habit-forming]] and the desire to use it can actually decrease with regular consumption. Like with most [[psychedelics]] it is most often thought to be self-regulating.  
4-HO-DPT is [[Addiction potential::not habit-forming]] and the desire to use it can actually decrease with regular consumption. Like with most [[psychedelics]], it is most often thought to be self-regulating.  


Tolerance to the effects of 4-HO-DPT are built [[Time to full tolerance::almost immediately after ingestion]]. After that, it takes about [[Time to half tolerance::3 days]] for the tolerance to be reduced to half and [[Time to zero tolerance::7 days]] to be back at baseline (in the absence of further consumption). 4-HO-DPT presents cross-tolerance with [[Cross-tolerance::all [[psychedelic]]s]], meaning that after the consumption of 4-HO-DPT all psychedelics will have a reduced effect.
Tolerance to the effects of 4-HO-DPT are built [[Time to full tolerance::almost immediately after ingestion]]. After that, it takes about [[Time to half tolerance::3 days]] for the tolerance to be reduced to half and [[Time to zero tolerance::7 days]] to be back at baseline (in the absence of further consumption). 4-HO-DPT presents cross-tolerance with [[Cross-tolerance::all [[psychedelic]]s]], meaning that after the consumption of 4-HO-DPT all psychedelics will have a reduced effect.


==Legal issues==
==Legal issues==
Due to its relative obscurity, the possession and sale of 4-HO-DPT is unscheduled in most countries.  
Due to its relative obscurity, 4-HO-DPT is unscheduled in most countries.  


*'''United Kingdom''' - It is illegal to produce, supply, or import this drug under the Psychoactive Substance Act, which came into effect on May 26th, 2016.<ref>Psychoactive Substances Act 2016 (Legislation.gov.uk) | http://www.legislation.gov.uk/ukpga/2016/2/contents/enacted</ref>
*'''United Kingdom''' - It is illegal to produce, supply, or import this drug under the Psychoactive Substance Act, which came into effect on May 26th, 2016.<ref>Psychoactive Substances Act 2016 (Legislation.gov.uk) | http://www.legislation.gov.uk/ukpga/2016/2/contents/enacted</ref>

Revision as of 06:26, 16 January 2017

4-HO-DPT
Chemical Nomenclature
Common names 4-HO-DPT, Procin
Substitutive name 4-Hydroxy-N,N-dipropyltryptamine
Systematic name 3-[2-(dipropylamino)ethyl]-1H-indol-4-ol
Class Membership
Psychoactive class Psychedelic
Chemical class Tryptamine
Routes of Administration

WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section.



⇣ Oral
Dosage
Threshold 20 mg
Light 40 - 60 mg
Common 60 - 90 mg
Strong 90 - 130 mg
Heavy 130 mg +
Duration
Total 5 - 8 hours
Onset 45 - 60 minutes
Come up 60 - 120 minutes
Peak 2 - 3 hours
Offset 1 - 2 hours



⇣ Insufflated
Dosage
Threshold 5 mg
Light 10 - 15 mg
Common 15 - 25 mg
Strong 25 - 35 mg
Heavy 35 mg +
Duration
Total 4 - 6 hours
Onset 15 - 45 minutes
Come up 30 - 45 minutes
Peak 1 - 3 hours
Offset 1 - 2 hours






DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.

Interactions
Summary sheet: 4-HO-DPT

4-HO-DPT (also known as 4-hydroxy-dipropyltryptamine) is a hallucinogenic psychedelic drug of the tryptamine class. Alexander Shulgin first synthesized 4-HO-DPT and documented it in his book TiHKAL (Tryptamines I Have Known and Loved). It is the 4-hydroxyl analog of DPT.[1]

Today it is either used recreationally or as an entheogenic compound and is typically acquired through the use of online research chemical vendors. Due to the difficulty of its synthesis, it remains relatively uncommon even for a substituted tryptamine and has very little history of human usage.

Chemistry

4-HO-DPT, or 4-hydroxy-N,N-dipropyltryptamine, is a synthetic indole molecule of the tryptamine class. Tryptamines share a core structure comprised of a bicyclic indole heterocycle attached at R3 to an amino group via an ethyl side chain. 4-HO-DPT is substituted at R4 of its indole heterocycle with a hydroxyl functional group OH−. It also contains two propyl chains bound to the terminal amine RN of its tryptamine backbone (DPT).

4-HO-DPT is a 4-hydroxy analog of 4-AcO-DPT and the N-substituted dipropyl homolog of psilocin (4-HO-DMT).

Pharmacology

Main article: Serotonergic psychedelic

Like with most psychedelic tryptamines, 4-HO-DPT is thought to act principally as a 5-HT2A partial agonist. The psychedelic effects are believed to come from 4-HO-DPT's binding efficacy at the 5-HT2A receptors. However, the role of these interactions and how they result in the psychedelic experience continues to remain elusive.

Subjective effects

Disclaimer: The effects listed below cite the Subjective Effect Index (SEI), an open research literature based on anecdotal user reports and the personal analyses of PsychonautWiki contributors. As a result, they should be viewed with a healthy degree of skepticism.

It is also worth noting that these effects will not necessarily occur in a predictable or reliable manner, although higher doses are more liable to induce the full spectrum of effects. Likewise, adverse effects become increasingly likely with higher doses and may include addiction, severe injury, or death ☠.

In comparison to other tryptamines such as 4-AcO-DMT and 4-HO-DMT, it is extremely similar in terms of its visual, cognitive and physical effects although it feels somewhat less natural and slightly more synthetic. It is also worth noting that it lacks the extremely uncomfortable physical side effects which are present within its close structural relative DPT. This allows it to feel far more similar to that of a generic or classical substituted tryptamine such as psilocin.

Physical effects

Cognitive effects

Visual effects

Enhancements

Suppressions

Distortions

Geometry

Hallucinatory states

Auditory effects

Toxicity and harm potential

Main articles: Research chemicals § Toxicity and harm potential & Responsible use § Hallucinogens

The toxicity and long-term health effects of recreational 4-HO-DPT use do not seem to have been studied in any scientific context and the exact toxic dose is unknown. This is because 4-HO-DPT is a research chemical with very little history of human usage. Anecdotal evidence from people within the psychonaut community who have tried 4-HO-DPT suggests that there are no negative health effects attributed to simply trying the drug by itself at low to moderate doses and using it very sparingly (but nothing can be completely guaranteed). Independent research should always be done to ensure that a combination of two or more substances is safe before consumption.

It is strongly recommended that one use harm reduction practices when using this drug.

Tolerance and addiction potential

4-HO-DPT is not habit-forming and the desire to use it can actually decrease with regular consumption. Like with most psychedelics, it is most often thought to be self-regulating.

Tolerance to the effects of 4-HO-DPT are built almost immediately after ingestion. After that, it takes about 3 days for the tolerance to be reduced to half and 7 days to be back at baseline (in the absence of further consumption). 4-HO-DPT presents cross-tolerance with [[Cross-tolerance::all psychedelics]], meaning that after the consumption of 4-HO-DPT all psychedelics will have a reduced effect.

Due to its relative obscurity, 4-HO-DPT is unscheduled in most countries.

  • United Kingdom - It is illegal to produce, supply, or import this drug under the Psychoactive Substance Act, which came into effect on May 26th, 2016.[2]
  • United States - 4-HO-DPT is unscheduled in the United States. It may be considered an analog of psilocin (which is a Schedule I drug under the Controlled Substances Act). As such, the sale for human consumption or could be prosecuted as crimes under the Federal Analog Act.

See also

References

  1. ↑ https://www.erowid.org/library/books_online/tihkal/tihkal20.shtml
  2. ↑ Psychoactive Substances Act 2016 (Legislation.gov.uk) | http://www.legislation.gov.uk/ukpga/2016/2/contents/enacted
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