4-HO-DPT

4-HO-DPT
Chemical Nomenclature
Common names	4-HO-DPT, Procin
Substitutive name	4-Hydroxy-N,N-dipropyltryptamine
Systematic name	3-[2-(dipropylamino)ethyl]-1H-indol-4-ol
Class Membership
Psychoactive class	Psychedelic
Chemical class	Tryptamine
Routes of Administration
WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section. ⇣ Oral Dosage Threshold 20 mg Light 40 - 60 mg Common 60 - 90 mg Strong 90 - 130 mg Heavy 130 mg + Duration Total 5 - 8 hours Onset 45 - 60 minutes Come up 60 - 120 minutes Peak 2 - 3 hours Offset 1 - 2 hours ⇣ Insufflated Dosage Threshold 5 mg Light 10 - 15 mg Common 15 - 25 mg Strong 25 - 35 mg Heavy 35 mg + Duration Total 4 - 6 hours Onset 15 - 45 minutes Come up 30 - 45 minutes Peak 1 - 3 hours Offset 1 - 2 hours DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.
Interactions

Summary sheet: 4-HO-DPT

4-HO-DPT (also known as 4-hydroxy-dipropyltryptamine) is a hallucinogenic psychedelic drug of the tryptamine class.

Alexander Shulgin first synthesized 4-HO-DPT and documented it in his book TiHKAL (Tryptamines I Have Known and Loved). It is the 4-hydroxyl analog of DPT..

Today it is either used recreationally or as an entheogenic compound and is typically acquired through the use of online research chemical vendors. Due to the difficulty of its synthesis, it remains relatively uncommon even for a substituted tryptamine and has very little history of human usage.

Chemistry

4-HO-DPT, or 4-hydroxy-N,N-dipropyltryptamine, is a synthetic indole molecule of the tryptamine class. Tryptamines share a core structure comprised of a bicyclic indole heterocycle attached at R₃ to an amino group via an ethyl side chain. 4-HO-DPT is substituted at R₄ of its indole heterocycle with a hydroxyl functional group OH−. It also contains two propyl chains bound to the terminal amine R_N of its tryptamine backbone (DPT).

4-HO-DPT is a 4-hydroxy analog of 4-AcO-DPT and the N-substituted dipropyl homolog of psilocin (4-HO-DMT).

Pharmacology

Main article: Serotonergic psychedelic

Like with most psychedelic tryptamines, 4-HO-DPT is thought to act principally as a 5-HT_2A partial agonist. The psychedelic effects are believed to come from 4-HO-DPT's binding efficacy at the 5-HT_2A receptors. However, the role of these interactions and how they result in the psychedelic experience continues to remain elusive.

Subjective effects

The effects listed below are based upon the subjective effects index and personal experiences of PsychonautWiki contributors. The listed effects will rarely (if ever) occur all at once, but heavier dosages will increase the chances and are more likely to induce a full range of effects.

In comparison to other tryptamines such as 4-AcO-DMT and 4-HO-DMT it is extremely similar in terms of its visual, cognitive and physical effects although it feels somewhat less natural and slightly more synthetic. It is also worth noting that it lacks the extremely uncomfortable physical side effects which are present within its close structural relative DPT. This allows it to feel far more similar to that of a generic or classical substituted tryptamine such as psilocin.

Physical effects

• Spontaneous tactile sensations
• Bodily control enhancement
• Increased heart rate
• Nausea
• Sedation
• Pupil dilation
• Tactile enhancement
• Sublingual numbing
• Physical euphoria
• Muscle relaxation

Cognitive effects

• Analysis enhancement
• Conceptual thinking
• Cognitive euphoria
• Delusions
• Emotion enhancement
• Immersion enhancement
• Increased music appreciation
• Memory suppression
  • Ego death
• Novelty enhancement
• Personal bias suppression
• Thought acceleration
• Thought loops
• Time distortion
• Unity and interconnectedness
• Laughter
• Language suppression
• Mindfulness

Visual effects

Enhancements

• Colour enhancement
• Pattern recognition enhancement
• Visual acuity enhancement

Suppressions

• Visual acuity suppression

Distortions

• Drifting (melting, breathing, morphing and flowing)
• Colour shifting
• Depth perception distortions
• Perspective distortions
• Symmetrical texture repetition
• Tracers
• After images
• Brightness alteration
• Diffraction
• Scenery slicing

Hallucinatory states

• Transformations
• Internal hallucinations (autonomous entities; settings, sceneries, and landscapes; alterations in perspective and scenarios and plots)

Auditory effects

• Enhancements
• Distortions
• Hallucinations

Toxicity and harm potential

Main articles: Research chemicals § Toxicity and harm potential & Responsible use § Hallucinogens

The toxicity and long-term health effects of recreational 4-HO-DPT use do not seem to have been studied in any scientific context and the exact toxic dose is unknown. This is because 4-HO-DPT is a research chemical with very little history of human usage. Anecdotal evidence from people within the psychonaut community who have tried 4-HO-DPT suggests that there are no negative health effects attributed to simply trying the drug by itself at low to moderate doses and using it very sparingly (but nothing can be completely guaranteed). Independent research should always be done to ensure that a combination of two or more substances is safe before consumption.

It is strongly recommended that one use harm reduction practices when using this drug.

Tolerance and addiction potential

4-HO-DPT is not habit-forming and the desire to use it can actually decrease with regular consumption. Like with most psychedelics it is most often thought to be self-regulating.

Tolerance to the effects of 4-HO-DPT are built almost immediately after ingestion. After that, it takes about 3 days for the tolerance to be reduced to half and 7 days to be back at baseline (in the absence of further consumption). 4-HO-DPT presents cross-tolerance with [[Cross-tolerance::all psychedelics]], meaning that after the consumption of 4-HO-DPT all psychedelics will have a reduced effect.

Legal issues

Due to its relative obscurity, the possession and sale of 4-HO-DPT is unscheduled in most countries.

• United Kingdom - It is illegal to produce, supply, or import this drug under the Psychoactive Substance Act, which came into effect on May 26th, 2016.
• United States - 4-HO-DPT is unscheduled in the United States. It may be considered an analog of psilocin (which is a Schedule I drug under the Controlled Substances Act). As such, the sale for human consumption or could be prosecuted as crimes under the Federal Analog Act.

See also

• Responsible use
• Research chemical
• DPT
• 4-HO-DMT
• 4-HO-MiPT
• 4-HO-MET
• Tryptamine

External links

• 4-HO-DPT (Wikipedia)
• 4-HO-DPT (TiHKAL)
• 4-HO-DPT (Bluelight)