Substituted tropanes: Difference between revisions
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==Chemistry== | ==Chemistry== | ||
Tropane alkaloids are molecules which contain a substituted tropane ring in their structure. Tropane is a nitrogen-containing bicyclic organic molecule | Tropane alkaloids are molecules which contain a substituted tropane ring in their structure. Tropane is a nitrogen-containing bicyclic organic molecule which consists of a piperidine and pyrrolidine ring fused at carbons R<sub>1</sub> and R<sub>5</sub> along with an additional methyl substitution at R<sub>N</sub>. Tropane alkaloids are commonly substituted at R<sub>3</sub> with an ether bridge (as seen in [[scopolamine]], [[atropine]], [[hyoscyamine]], and [[cocaine]]). | ||
==Pharmacology== | ==Pharmacology== | ||
Revision as of 07:13, 13 November 2016
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Tropane alkaloids are a class of chemicals that include compounds with psychoactive effects.
Chemistry
Tropane alkaloids are molecules which contain a substituted tropane ring in their structure. Tropane is a nitrogen-containing bicyclic organic molecule which consists of a piperidine and pyrrolidine ring fused at carbons R1 and R5 along with an additional methyl substitution at RN. Tropane alkaloids are commonly substituted at R3 with an ether bridge (as seen in scopolamine, atropine, hyoscyamine, and cocaine).
Pharmacology
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Tropane alkaloids are mostly anti-cholinergics (antagonistic action on acetylcholine receptors) or stimulants (prevention of dopamine reuptake).
Examples
Tropane alkaloids are seen throughout organic chemistry and include psychoactive and anaesthetic compounds.
Anticholinergic drugs:
Stimulant drugs:
See also
References
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