PMMA

PMMA can cause serious side effects even at moderate doses, such as hyperthermia and serotonin syndrome, which can easily result in death or hospitalization. As a result, it is strongly discouraged to use this substance. Please see this section for more details.

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PMMA
Chemical Nomenclature
Common names	PMMA
Substitutive name	para-Methoxymethamphetamine, 4-Methoxymethamphetamine
Systematic name	1-(4-Methoxyphenyl)-N-methylpropan-2-amine
Class Membership
Psychoactive class	Entactogen
Chemical class	Amphetamine
Routes of Administration
WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section. ⇣ Oral Dosage Common 100 - 120 mg Strong Higher dosages can result in serious hyperthermia and eventually death. Duration Total short DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.
Interactions

Summary sheet: PMMA

PMMA (also known as para-Methoxymethamphetamine or 4-MMA) is a highly dangerous and toxic drug of the amphetamine class, which is closely related to PMA. Like PMA, it has extremely dangerous side effects, which can result in death. At lower dosages, it's effects are somewhat different from PMA, with reduced tendency to cause severe hyperthermia and more entactogenic effects, although at higher dosages it does produces the same risk as PMA. It's history of use is unknown, but it has appeared more frequently in the mid-2000s and 2010s.

Chemistry

PMMA (para-Methoxymethamphetamine or 4-MMA) is a molecule of the amphetamine class. Molecules of the amphetamine class contain a phenethylamine core featuring a phenyl ring bound to an amino (NH₂) group through an ethyl chain with an additional methyl substitution at R_α. It contains a methoxy (OCH₃) functional group bound to the R₄ carbon of the phenyl ring, as well as a methyl substitution at R_N. It is the methylated version of PMA and the 4-Methoxy analog of Methamphetamine.

Pharmacology

This pharmacology section is incomplete. You can help by adding to it.

PMMA, like PMA most likely acts as a selective serotonin releasing agent (SSRA) with weak effects on dopamine and norepinephrine transporters. However, relative to MDMA, it is considerably less effective as a releaser of serotonin with properties more akin to a reuptake inhibitor in comparison. It evokes robust hyperthermia while producing only modest hyperactivity and serotonergic neurotoxicity, substantially lower than that caused by MDMA. Anecdotal reports suggest it is not particularly euphoric at all, perhaps even dysphoric in contrast. PMMA has also been shown to act as a potent, reversible inhibitor of the enzyme MAO-A with no significant effects on MAO-B, and the combination of this property and serotonin release is likely responsible for its high lethality potential. It is likely metabolized to PMA in the body, like methamphetamine is metabolized to amphetamine.

It appears that PMMA elevates body temperatures dramatically; the cause of this property is suspected to be related to its ability to inhibit MAO-A and at the same time releasing large amounts of serotonin, effectively causing serotonin syndrome. It appears that PMMA activates the hypothalamus much more strongly than MDMA and other drugs like ephedrine, thereby causing rapid increases in body temperature (which is the major cause of death in PMMA mortalities).

Subjective effects

This subjective effects section is a stub. As such, it is still in progress and may contain incomplete or wrong information. You can help by expanding or correcting it.

The effects listed below are based upon the subjective effects index and personal experiences of PsychonautWiki contributors. The listed effects will rarely (if ever) occur all at once, but heavier dosages will increase the chances and are more likely to induce a full range of effects.

Physical effects

• Stimulation - In terms of its effects on the user's physical energy levels, PMMA is commonly regarded as moderately stimulating and energetic exclusively at lower dosages.
• Abnormal heartbeat
• Appetite suppression
• Dehydration
• Dizziness - This effect is significantly more common with PMMA than it is with methamphetamine or MDMA
• Increased bodily temperature - The most common cause of death from PMMA is due to severe hyperthermia.
• Increased blood pressure
• Increased heart rate
• Increased perspiration
• Nausea and vomiting
• Pupil dilation
• Rapid breathing - People commonly report "not being able to breath".
• Seizures - This is significantly more common with PMMA than with almost any other substance.
• Teeth grinding
• Temporary erectile dysfunction
• Vasoconstriction
• Vibrating vision

Cognitive effects

• Anxiety or Anxiety suppression - This depends greatly on the dosage, as higher dosages are almost guaranteed to bring anxiety, due to all the adverse effects.
• Cognitive euphoria or Cognitive dysphoria - This depends greatly on the dosage, as higher dosages are almost guaranteed to bring dysphoria, due to all the adverse effects.
• Dream suppression
• Increased libido - This is only apparent at lower dosages, as anything higher will usually diminish these effects, due to all the adverse effects.
• Motivation enhancement - This is only apparent at lower dosages, as anything higher will usually diminish these effects, due to all the adverse effects.
• Time distortion
• Wakefulness

Visual effects

At moderate to high dosages, PMMA is capable of producing typically mild or moderate visual distortions, which are usually more common and pronounced than with MDMA, but significantly less when compared with most psychedelics, such as 2C-B or LSD.

Suppressions

• Double vision

Distortions

• Drifting (melting, breathing, morphing and flowing) - This effects is more pronounced than MDMA.
• Tracers
• Symmetrical texture repetition

Toxicity and harm potential

This toxicity and harm potential section is a stub. As a result, it may contain incomplete or even dangerously wrong information! You can help by expanding upon or correcting it. Note: Always conduct independent research and use harm reduction practices if using this substance.

PMMA can be extremely toxic at moderate or high dosages.

Legal issues

• Canada: PMMA is a Schedule I substance.
• Germany: PMMA is an Anlage I controlled substance.
• United States: PMMA is unscheduled, but can be controlled under the Federal Analog Act.
• United Kingdom: PMMA is a Class A drug.

See also

• Responsible use
• Substituted amphetamine
• Entactogen
• PMA