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Revision as of 20:23, 24 October 2016

LSZ
Chemical Nomenclature
Common names LSZ, LA-SS-Az, Diazedine, Lambda
Substitutive name Lysergic acid 2,4-dimethylazetidide
Systematic name (8β)-8-{[(2S,4S)-2,4-Dimethylazetidin-1-yl]carbonyl}-6-methyl-9,10-didehydroergoline
Class Membership
Psychoactive class Psychedelic
Chemical class Lysergamide
Routes of Administration

WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section.



⇣ Oral
Dosage
Threshold 50 µg
Light 100 - 150 µg
Common 150 - 300 µg
Strong 300 - 400 µg
Heavy 400 µg +
Duration
Total 6 - 10 hours
Onset 20 - 60 minutes
Come up 30 - 60 minutes
Peak 3 - 5 hours
Offset 2 - 3 hours
After effects 6 - 24 hours









DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.

Interactions
Summary sheet: LSZ

LSZ (also known as lysergic acid 2,4-dimethylazetidide or Lambda) is a hallucinogenic psychedelic drug of the lysergamide family.

It was developed as a rigid analog of LSD with the diethylamide group constrained into an azetidine ring in order to map the binding site at the 5-HT2A receptor. This was done via a team led by David E. Nichols at Purdue University.

LSZ has little to no history of human usage prior to 2012 when it appeared on some research chemical markets in the UK.[1][2] LSZ later gained international popularity through a small cluster of mail-order novel psychedelic shops that appeared in 2013.[3]

There have also been several unconfirmed reports of LSZ being synthesized in illicit laboratories and distributed on blotter paper or in liquid solution under names such as "diazedine" and "λ".[4][5]

Chemistry

LSZ, or d-lysergic acid 2,4-dimethylazetidide, is a semi-synthethic alkaloid of the lysergamide famiy. It contains a core structure of lysergic acid with an amine functional group bound to RN of the chemical structure. This core polycyclic structure is an indole derivative, and has tryptamine and phenethylamine groups embedded within it.

The structure contains a bicyclic hexahydroindole fused to a bicyclic quinoline group (lysergic acid). At carbon 8 of the quinoline, an amide group is bound. Additionally, the substitutions of the terminal nitrogen atom of the amide group form a 2,4-dimethylazetidide group. LSZ is additionally substituted at carbon 6 with a methyl group.

There are three possible stereoisomers around the azetidine ring with the (S,S)-(+) isomer being the most active. It is slightly more potent than LSD itself in drug discrimination tests using trained rats.[6]

Pharmacology

Main article: Serotonergic psychedelic

LSZ likely acts as a 5-HT2A partial agonist. The psychedelic effects are believed to come from LSZ's efficacy at the 5-HT2A receptors. However, the role of these interactions and how they result in the psychedelic experience continues to remain elusive.

Subjective effects

 This subjective effects section is a stub.

As such, it is still in progress and may contain incomplete or wrong information.

You can help by expanding or correcting it.

The effects listed below are based upon the subjective effects index and personal experiences of PsychonautWiki contributors. The listed effects will rarely (if ever) occur all at once, but heavier dosages will increase the chances and are more likely to induce a full range of effects.

Physical effects

Cognitive effects

Visual effects

Enhancements

Distortions

Geometry

Hallucinatory states

Auditory effects

Toxicity and harm potential

Main articles: Research chemicals § Toxicity and harm potential & Responsible use § Hallucinogens

The toxicity and long-term health effects of recreational LSZ do not seem to have been studied in any scientific context and the exact toxic dose is unknown. This is because LSZ is a research chemical with very little history of human usage. Anecdotal evidence from people within the psychonaut community who have tried LSZ suggests that there are no negative health effects attributed to simply trying the drug by itself at low to moderate doses and using it very sparingly (but nothing can be completely guaranteed). Independent research should always be done to ensure that a combination of two or more substances is safe before consumption.

It is strongly recommended that one use harm reduction practices when using this drug.

Tolerance and addiction potential

LSZ is not habit-forming and the desire to use it can actually decrease with use. It is most often self-regulating.

Tolerance to the effects of LSZ are built almost immediately after ingestion. After that, it takes about 3 days for the tolerance to be reduced to half and 7 days to be back at baseline (in the absence of further consumption). LSZ presents cross-tolerance with [[Cross-tolerance::all psychedelics]], meaning that all psychedelics will have a reduced effect after the consumption of LSZ.

This legality section is a stub.

As such, it may contain incomplete or wrong information. You can help by expanding it.

  • U.K. - On June 10, 2014 the U.K. Advisory Council on the Misuse of Drugs (ACMD) recommended that LSZ be specifically named in the U.K. Misuse of Drugs Act as a class A drug despite not identifying any harm associated with its use.[1] The U.K. Home Office accepted this advice and announced a ban of the substance to be enacted on January 6th, 2015 as part of the Misuse of Drugs Act 1971 (Amendment) (No. 2) Order 2014. This drug is illegal under the Psychoactive Substance Act, which came into effect on May 26th, 2016.[7]
  • Switzerland - LSZ was added to the list of controlled substances on the 1st of December 2015.[8]
  • Latvia - LSZ is illegal in Latvia. Although it isn't officially scheduled, it is controlled as an LSD structural analog due to an amendment made on June 1th, 2015.[9]
  • Sweden - Following its sale as a designer drug, LSZ was made illegal in Sweden on 26 January 2016.[10]

See also

References

  1. ↑ 1.0 1.1 http://www.ukchemicalresearch.org/Thread-LSZ
  2. ↑ ACMD (10 June 2014). "Update of the Generic Definition for Tryptamines" | https://www.gov.uk/government/uploads/system/uploads/attachment_data/file/318693/UpdateGenericDefinitionTryptamines.pdf
  3. ↑ The Drug Revolution That No One Can Stop | https://medium.com/matter/the-drug-revolution-that-no-one-can-stop-19f753fb15e0#.fupvbuawp
  4. ↑ Life Is a Cosmic Giggle on the Breath of the Universe | http://www.vice.com/en_ca/read/life-is-a-cosmic-giggle-803-v18n5?Contentpage=3
  5. ↑ Cole, Krystle (2005). Lysergic. Indianapolis: Dog Ear Publishing. ISBN 1-59858-007-8.
  6. ↑ Lysergamides of isomeric 2,4-dimethylazetidines map the binding orientation of the diethylamide moiety in the potent hallucinogenic agent N,N-diethyllysergamide (LSD) (PubMed.gov / NCBI) | https://www.ncbi.nlm.nih.gov/pubmed/12213075
  7. ↑ Psychoactive Substances Act 2016 (Legislation.gov.uk) | http://www.legislation.gov.uk/ukpga/2016/2/contents/enacted
  8. ↑ https://www.admin.ch/opc/de/official-compilation/2015/5093.pdf
  9. ↑ Noteikumi par Latvijā kontrolējamajām narkotiskajām vielām, psihotropajām vielām un prekursoriem (2.4.punkts) | http://likumi.lv/doc.php?id=121086
  10. ↑ (in Swedish) Folkhälsomyndigheten. | https://www.folkhalsomyndigheten.se/nyheter-och-press/nyhetsarkiv/2016/januari/31-nya-substanser-klassas-som-narkotika-eller-halsofarlig-vara/
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